Barry H. Hirst

Overview

Best Publications

• The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability.

  Lauretta M.S Chan;Simon Lowes;Barry H Hirst

  762
  Citations

• Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators.

  J Hunter;M A Jepson;T Tsuruo;N L Simmons

  491
  Citations

• M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells

  M. Ann Clark;Barry H. Hirst;Mark A. Jepson

  456
  Citations

• Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption

  Janice Hunter;Barry H. Hirst

  382
  Citations

• Exploiting M cells for drug and vaccine delivery.

  MA Clark;Mark A Jepson;BH Hirst

  307
  Citations

• Drug Absorption Limited by P-Glycoprotein-Mediated Secretory Drug Transport in Human Intestinal Epithelial Caco-2 Cell Layers

  Janice Hunter;Barry H. Hirst;Nicholas L. Simmons

  299
  Citations

• Preferential interaction of Salmonella typhimurium with mouse Peyer's patch M cells

  M.A Clark;M.A Jepson;N.L Simmons;B.H Hirst

  297
  Citations

• Lectin-mediated mucosal delivery of drugs and microparticles

  M.Ann Clark;Barry H Hirst;Mark A Jepson

  295
  Citations

• Differential expression of lectin-binding sites defines mouse intestinal M-cells.

  M A Clark;M A Jepson;N L Simmons;T A Booth

  269
  Citations

• Pili mediate specific adhesion of Streptococcus pyogenes to human tonsil and skin

  Emily L. Abbot;Wendy D. Smith;Gerard P. S. Siou;Carlos Chiriboga

  248
  Citations

• Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo

  N Foster;MA Clark;Mark A Jepson;BH Hirst

  198
  Citations

• Evidence for a general role for non-catalytic thermostabilizing domains in xylanases from thermophilic bacteria

  C M G A Fontes;G P Hazlewood;E Morag;J Hall

  191
  Citations

• Substrate upregulation of the human small intestinal peptide transporter, hPepT1

  Dianne Walker;David T. Thwaites;Nicholas L. Simmons;Harry J. Gilbert

  186
  Citations

• Transepithelial glycylsarcosine transport in intestinal Caco-2 cells mediated by expression of H(+)-coupled carriers at both apical and basal membranes.

  D. T. Thwaites;C. D. A. Brown;B. H. Hirst;N. L. Simmons

  176
  Citations

• Targeting polymerised liposome vaccine carriers to intestinal M cells

  M Ann Clark;Helen Blair;Likan Liang;Robert N Brey

  172
  Citations

• Increased tyrosine phosphorylation causes redistribution of adherens junction and tight junction proteins and perturbs paracellular barrier function in MDCK epithelia

  Carla B. Collares-Buzato;Mark A. Jepson;Nicholas L. Simmons;Barry H. Hirst

  172
  Citations

• Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells.

  Hannah M. Prime-Chapman;Richard A. Fearn;Anne E. Cooper;Vanessa Moore

  165
  Citations

• M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery

  Mark A Jepson;MA Clark;BH Hirst

  165
  Citations

• Targeting to intestinal M cells.

  Mark A Jepson;MA Clark;N Foster;CM Mason

  162
  Citations

• Selective binding and transcytosis of latex microspheres by rabbit intestinal M cells.

  Mark A. Jepson;Nicholas L. Simmons;Tor C. Savidge;Peter S. James

  145
  Citations