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D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
10589
World Ranking
13326
National Ranking
56

Overview

David J. Brayden is affiliated with University College Dublin in Ireland and specializes primarily in the fields of Pharmacology, Toxicology, and Pharmaceutics, with a significant body of work in Medicine. Their research focuses extensively on Pharmaceutical Science, supported by contributions in Molecular Biology, Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, and Pediatrics, Perinatology and Child Health.

Brayden's work spans several key topics, prominently including:

  • Advanced Drug Delivery Systems
  • Drug Solubility and Delivery Systems
  • Pharmaceutical studies and practices
  • Drug Transport and Resistance Mechanisms
  • Infant Nutrition and Health
  • Proteins in Food Systems
  • Diabetes Treatment and Management

The scientist has authored numerous papers across respected journals. Recent notable publications include:

  • Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches, 2020, Advanced Drug Delivery Reviews
  • Transient Permeation Enhancer® (TPE®) technology for oral delivery of octreotide: a technological evaluation, 2021, Expert Opinion on Drug Delivery

Frequent collaborators include Fiona McCartney, Sam Maher, Ana Beloqui, Vivien Stuettgen, and Daniel Crean, with multiple joint publications reflecting ongoing research partnerships.

David J. Brayden has published extensively in high-profile venues, most frequently in the International Journal of Pharmaceutics and the European Journal of Pharmaceutical Sciences. Other common platforms for their research include Advanced Drug Delivery Reviews, Pharmaceutics, and Expert Opinion on Drug Delivery.

Their research often highlights the development and evaluation of novel drug delivery mechanisms and permeation enhancers, investigating oral peptide delivery and safety concerns associated with excipients in oral formulations. This work contributes to advancing understanding in drug transport and improving pharmaceutical efficacy.

Best Publications

  • Advances in PEGylation of important biotech molecules: delivery aspects

    Sinéad M Ryan;Giuseppe Mantovani;Xuexuan Wang;David M Haddleton

  • Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia

    Siobhán McClean;Ena Prosser;Eucharia Meehan;Denise O'Malley

  • Intestinal permeation enhancers for oral peptide delivery.

    Sam Maher;Randall J. Mrsny;David James Brayden

  • Expression of specific markers and particle transport in a new human intestinal M-cell model.

    Elisabet Gullberg;Maurice Leonard;Johan Karlsson;Ann M. Hopkins

  • In vitro models of the intestinal barrier. The report and recommendations of ECVAM Workshop 46. European Centre for the Validation of Alternative methods.

    Eric Le Ferrec;Christophe Chesne;Per Artusson;David Brayden

  • Keynote review: intestinal Peyer's patch M cells and oral vaccine targeting.

    David J. Brayden;Mark A. Jepson;Alan W. Baird

  • Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

    T.A.S. Aguirre;D. Teijeiro-Osorio;M. Rosa;I.S. Coulter

  • Antibacterial effects of poly(2-(dimethylamino ethyl)methacrylate) against selected gram-positive and gram-negative bacteria.

    Lee-Anne Betty Rawlinson;Sinéad M. Ryan;Giuseppe Mantovani;Jay A. Syrett

  • Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic.

    Sam Maher;Thomas W. Leonard;Jette Jacobsen;David J. Brayden

  • Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10).

    Caroline Twarog;Sarinj Fattah;Joanne Heade;Sam Maher

  • Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies

    Régis Coco;Laurence Plapied;Vincent Pourcelle;Christine Jérôme

  • Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches.

    David J Brayden;T. A. Hill;D. P. Fairlie;S. Maher

  • Protection against Bordetella pertussis infection following parenteral or oral immunization with antigens entrapped in biodegradable particles: effect of formulation and route of immunization on induction of Th1 and Th2 cells.

    Margaret A. Conway;Laura Madrigal-Estebas;Siobhan McClean;David J. Brayden

  • Targeting polymerised liposome vaccine carriers to intestinal M cells

    M Ann Clark;Helen Blair;Likan Liang;Robert N Brey

  • Direct peptide bioconjugation/PEGylation at tyrosine with linear and branched polymeric diazonium salts.

    Mathew W. Jones;Giuseppe Mantovani;Claudia A. Blindauer;Sinead M. Ryan

  • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET™

    Thomas W Leonard;John Lynch;Michael J McKenna;David J Brayden

  • Controlled release technologies for drug delivery.

    David J Brayden

  • Safety concerns over the use of intestinal permeation enhancers: A mini-review

    Fiona McCartney;John P. Gleeson;David James Brayden

  • Oral vaccination in man using antigens in particles: current status

    David J Brayden

  • Intestinal Peyer's patch M cells and oral vaccine targeting

    DJ Brayden;Mark A Jepson;AW Baird

Frequent Co-Authors

David M. Haddleton
David M. Haddleton University of Warwick
David Lo
David Lo University of California, Riverside
Peter J. O'Brien
Peter J. O'Brien University College Dublin
Elias Fattal
Elias Fattal University of Paris-Saclay
Per Artursson
Per Artursson Uppsala University
Owen I. Corrigan
Owen I. Corrigan Trinity College Dublin
Barry H. Hirst
Barry H. Hirst Newcastle University
Kenneth A. Dawson
Kenneth A. Dawson University College Dublin
Adriana Raffin Pohlmann
Adriana Raffin Pohlmann Federal University of Rio Grande do Sul
Andreas Heise
Andreas Heise Royal College of Surgeons in Ireland

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