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D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
60953
World Ranking
2633
National Ranking
1371

Overview

Donna D. Zhang is affiliated with the University of Arizona in the United States and has a research portfolio primarily focused on biochemistry, genetics, and molecular biology, with additional contributions in medicine.

Their scientific work spans several subfields, including molecular biology, pulmonary and respiratory medicine, cancer research, organic chemistry, and epidemiology. Key research topics addressed by Donna D. Zhang cover genomics, phytochemicals, and oxidative stress; ferroptosis and cancer prognosis; RNA modifications and cancer; glutathione transferases and polymorphisms; epigenetics and DNA methylation; circular RNAs in diseases; and heat shock proteins research.

Donna D. Zhang has published extensively in several prominent venues. Frequent publication outlets include:

  • Redox Biology
  • Journal of Medicinal Chemistry
  • Nature Cell Biology
  • Cell chemical biology
  • Seminars in Cancer Biology

Their recent scholarly papers showcase a strong focus on ferroptosis and molecular regulation mechanisms. Representative publications are:

  • "Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis" (2020), Cell chemical biology
  • "NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8" (2023), Science Advances
  • "A guideline on the molecular ecosystem regulating ferroptosis" (2024), Nature Cell Biology
  • "International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis" (2024), Autophagy
  • "The role of natural products in revealing NRF2 function" (2020), Natural Product Reports

Throughout their career, Donna D. Zhang has collaborated with multiple researchers. Frequent co-authors include:

  • Eli Chapman
  • Matthew Dodson
  • Annadurai Anandhan
  • Joe G. N. Garcia
  • Cody J. Schmidlin

Their research reflects an interdisciplinary approach integrating molecular and biochemical perspectives to explore cellular defense systems, cancer biology, and the chemical biology of natural products. Donna D. Zhang's contributions have focused heavily on understanding the molecular mechanisms underlying oxidative stress responses and cell death pathways such as ferroptosis, which holds significance for cancer prognosis and therapeutic strategies.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

    Brent R. Stockwell;José Pedro Friedmann Angeli;Hülya Bayir;Ashley I. Bush

  • Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

    Donna D. Zhang;Mark Hannink

  • NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

    Matthew Dodson;Raul Castro-Portuguez;Donna D. Zhang

  • Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

    Donna D. Zhang;Shih Ching Lo;Janet V. Cross;Dennis J. Templeton

  • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.

    Sara B. Cullinan;Donna Zhang;Mark Hannink;Edward Arvisais

  • The emerging role of the Nrf2–Keap1 signaling pathway in cancer

    Melba C. Jaramillo;Donna D. Zhang

  • Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

    Donna D. Zhang

  • NRF2 and the Hallmarks of Cancer.

    Montserrat Rojo de la Vega;Eli Chapman;Donna D. Zhang

  • Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

    Xiao Jun Wang;Zheng Sun;Nicole F. Villeneuve;Shirley Zhang

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

    Alexandria Lau;Xiao Jun Wang;Fei Zhao;Nicole F. Villeneuve

  • Dual roles of Nrf2 in cancer

    Alexandria Lau;Nicole F. Villeneuve;Zheng Sun;Pak Kin Wong

  • Direct interaction between Nrf2 and p21Cip1/WAF1 upregulates the Nrf2-mediated antioxidant response

    Weimin Chen;Zheng Sun;Xiao Jun Wang;Tao Jiang

  • Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

    Dongmei Ren;Nicole F. Villeneuve;Tao Jiang;Tongde Wu

  • Therapeutic Potential of Nrf2 Activators in Streptozotocin-Induced Diabetic Nephropathy

    Hongting Zheng;Hongting Zheng;Samantha A. Whitman;Wei Wu;Wei Wu;Georg T. Wondrak

  • p62 links autophagy and Nrf2 signaling

    Tao Jiang;Bryan Harder;Montserrat Rojo de la Vega;Pak K. Wong

  • The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

    Tao Jiang;Zheping Huang;Yifeng Lin;Zhigang Zhang

  • Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

    Nicole F. Villeneuve;Alexandria Lau;Donna D. Zhang

Frequent Co-Authors

Deyu Fang
Deyu Fang Northwestern University
Joe G.N. Garcia
Joe G.N. Garcia University of Arizona
Ting Wang
Ting Wang Washington University in St. Louis
Eileen White
Eileen White Rutgers, The State University of New Jersey
Evelina Gatti
Evelina Gatti Aix-Marseille University
Sergio Lavandero
Sergio Lavandero University of Chile
Yi Lu
Yi Lu University of Illinois at Urbana-Champaign
Maurizio Molinari
Maurizio Molinari Universita della Svizzera Italiana
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center
A. A. Leslie Gunatilaka
A. A. Leslie Gunatilaka University of Arizona

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