Ken Itoh

Overview

Best Publications

• AN NRF2/SMALL MAF HETERODIMER MEDIATES THE INDUCTION OF PHASE II DETOXIFYING ENZYME GENES THROUGH ANTIOXIDANT RESPONSE ELEMENTS

  Ken Itoh;Tomoki Chiba;Satoru Takahashi;Tetsuro Ishii

  4401
  Citations

• Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

  Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii

  3995
  Citations

• Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

  Albena T. Dinkova-Kostova;W. David Holtzclaw;Robert N. Cole;Ken Itoh

  2266
  Citations

• Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

  Tetsuro Ishii;Ken Itoh;Satoru Takahashi;Hideyo Sato

  2124
  Citations

• Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.

  Minerva Ramos-Gomez;Mi Kyoung Kwak;Patrick M. Dolan;Ken Itoh

  1374
  Citations

• Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

  Michael McMahon;Ken Itoh;Masayuki Yamamoto;John D. Hayes

  1251
  Citations

• Molecular mechanism activating nrf2–keap1 pathway in regulation of adaptive response to electrophiles

  Ken Itoh;Kit I Tong;Masayuki Yamamoto

  1177
  Citations

• High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes.

  Akiko Enomoto;Ken Itoh;Eiko Nagayoshi;Junko Haruta

  1016
  Citations

• Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

  Nobunao Wakabayashi;Ken Itoh;Junko Wakabayashi;Hozumi Motohashi

  1008
  Citations

• Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles.

  Ken Itoh;Nobunao Wakabayashi;Yasutake Katoh;Tetsuro Ishii

  967
  Citations

• Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival.

  Mi Kyoung Kwak;Nobunao Wakabayashi;Nobunao Wakabayashi;Ken Itoh;Hozumi Motohashi

  802
  Citations

• Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.

  Mi Kyoung Kwak;Ken Itoh;Masayuki Yamamoto;Thomas W. Kensler

  719
  Citations

• Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.

  Kit I. Tong;Yasutake Katoh;Hideki Kusunoki;Ken Itoh

  668
  Citations

• Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

  Yasutake Katoh;Ken Itoh;Eisaku Yoshida;Makoto Miyagishi

  652
  Citations

• Discovery of the negative regulator of Nrf2, keap1: A historical overview

  Ken Itoh;Junsei Mimura;Masayuki Yamamoto

  648
  Citations

• Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence

  Paul Nioi;Michael McMahon;Ken Itoh;Masayuki Yamamoto

  593
  Citations

• Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

  Simon A Chanas;Qing Jiang;Michael McMahon;Gail K McWalter

  588
  Citations

• Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.

  Hiromi Sasaki;Hideyo Sato;Kazumi Kuriyama-Matsumura;Kanako Sato

  569
  Citations

• Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

  Ken Itoh;Mie Mochizuki;Yukio Ishii;Tetsuro Ishii

  568
  Citations

• Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism A TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEX

  Michael J. McMahon;Nerys Thomas;Ken Itoh;Masayuki Yamamoto

  549
  Citations