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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
49112
World Ranking
996
National Ranking
51

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Koji Uchida is affiliated with the University of Tokyo in Japan and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. With a focus on Molecular Biology, Immunology, Pulmonary and Respiratory Medicine, Physiology, and Genetics, their research spans various fundamental and applied biomedical topics.

Their scientific work includes a number of recent publications, among which are:

  • Fatal COVID-19 pulmonary disease involves ferroptosis, 2024, Nature Communications
  • Reprogrammed transsulfuration promotes basal-like breast tumor progression via realigning cellular cysteine persulfidation, 2021, Proceedings of the National Academy of Sciences
  • Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified, 2021, Scientific Reports
  • Transferrin Receptor Is a Specific Ferroptosis Marker, 2020, Cell Reports
  • PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates, 2020, iScience

Uchida's research often addresses topics related to free radicals, antioxidants, and oxidative stress mechanisms. Key topics covered in their work include:

  • Free Radicals and Antioxidants
  • Advanced Glycation End Products research
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Cardiovascular and exercise physiology
  • Extracellular vesicles in disease
  • Redox biology and oxidative stress
  • High Altitude and Hypoxia

Koji Uchida collaborates regularly with several researchers, notably:

  • Takahiro Shibata (23 joint publications)
  • Jun Yoshitake (8 joint publications)
  • Masanori Itakura (8 joint publications)
  • Kosuke Yamaguchi (7 joint publications)
  • Michael J. Joyner (7 joint publications)

Their work is frequently published in established scientific venues, with multiple articles appearing in:

  • Journal of Biological Chemistry (7 publications)
  • Nature Communications (4 publications)
  • The FASEB Journal (4 publications)
  • Free Radical Research (4 publications)
  • Antioxidants (3 publications)

This research profile illustrates a significant engagement with biomedical research topics fundamental to understanding disease mechanisms, stress responses, and metabolic pathways. Their multidisciplinary approach integrates molecular biology and physiology with clinical and biochemical insights.

Best Publications

  • 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress.

    Koji Uchida

  • Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

    Asako Yoritaka;Nobutaka Hattori;Koji Uchida;Masashi Tanaka

  • A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide

    Robert J. Mark;Mark A. Lovell;William R. Markesbery;Koji Uchida

  • Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.

    Takanori Tsuda;Fumihiko Horio;Koji Uchida;Hiromitsu Aoki

  • Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1.

    Akira Kobayashi;Moon Il Kang;Yoriko Watai;Kit I. Tong

  • Protein-bound acrolein: Potential markers for oxidative stress

    Koji Uchida;Masamichi Kanematsu;Kensuke Sakai;Tsukasa Matsuda

  • Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model

    S. Toyokuni;T. Tanaka;Y. Hattori;Y. Nishiyama

  • Role of reactive aldehyde in cardiovascular diseases.

    Koji Uchida

  • Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

    Robert J. Mark;Zhen Pang;James W. Geddes;Koji Uchida

  • Mitochondrial Electron Transport Complex I Is a Potential Source of Oxygen Free Radicals in the Failing Myocardium

    Tomomi Ide;Hiroyuki Tsutsui;Shintaro Kinugawa;Hideo Utsumi

  • Acrolein Is a Product of Lipid Peroxidation Reaction: FORMATION OF FREE ACROLEIN AND ITS CONJUGATE WITH LYSINE RESIDUES IN OXIDIZED LOW DENSITY LIPOPROTEINS *

    Koji Uchida;Masamichi Kanematsu;Yasujiro Morimitsu;Toshihiko Osawa

  • Covalent attachment of 4-hydroxynonenal to glyceraldehyde-3-phosphate dehydrogenase. A possible involvement of intra- and intermolecular cross-linking reaction.

    K Uchida;E R Stadtman

  • Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

    Kathryn F. Mills;Shohei Yoshida;Liana R. Stein;Alessia Grozio

  • Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation: 4-HYDROXY-2-NONENAL IS A POTENTIAL INDUCER OF INTRACELLULAR PEROXIDE PRODUCTION *

    Koji Uchida;Mihoko Shiraishi;Yuko Naito;Yasuyoshi Torii

  • Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

    Y Ihara;S Toyokuni;K Uchida;H Odaka

  • Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

    Koji Uchida;E. R. Stadtman

  • Transferrin Receptor Is a Specific Ferroptosis Marker

    Huizhong Feng;Kenji Schorpp;Jenny Jin;Carrie E. Yozwiak

  • 15-Deoxy-Δ12,14-prostaglandin J2: A PROSTAGLANDIN D2 METABOLITE GENERATED DURING INFLAMMATORY PROCESSES

    Takahiro Shibata;Mitsuhiro Kondo;Toshihiko Osawa;Noriyuki Shibata

  • Chemistry and biochemistry of lipid peroxidation products.

    Françoise Guéraud;Mustafa Atalay;Nicolaus Bresgen;Ana Čipak

  • Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

    Ken Itoh;Mie Mochizuki;Yukio Ishii;Tetsuro Ishii

Frequent Co-Authors

Toshihiko Osawa
Toshihiko Osawa Nagoya University
Shinya Toyokuni
Shinya Toyokuni Nagoya University
Shunro Kawakishi
Shunro Kawakishi Sugiyama Jogakuen University
Yoshimasa Nakamura
Yoshimasa Nakamura Okayama University
Hiroshi Hiai
Hiroshi Hiai Kyoto University
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Earl R. Stadtman
Earl R. Stadtman National Institutes of Health
Yoji Kato
Yoji Kato University of Hyogo
Nobutaka Hattori
Nobutaka Hattori Juntendo University

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