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Shinya Toyokuni

Shinya Toyokuni

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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
106
Citations
58160
World Ranking
1131
National Ranking
65

Medicine

D-Index
106
Citations
58401
World Ranking
6387
National Ranking
144

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Shinya Toyokuni is affiliated with Nagoya University in Japan and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including molecular biology, pulmonary and respiratory medicine, radiology, nuclear medicine and imaging, nutrition and dietetics, and cancer research.

The research conducted by Toyokuni frequently addresses topics such as plasma applications and diagnostics, ferroptosis and cancer prognosis, trace elements in health, iron metabolism and disorders, occupational and environmental lung diseases, extracellular vesicles in disease, and RNA modifications related to cancer.

Toyokuni has published notable papers on a range of subjects, including:

  • "Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo," 2022, Nature Metabolism
  • "Ferroptosis in health and disease," 2024, Redox Biology
  • "A guideline on the molecular ecosystem regulating ferroptosis," 2024, Nature Cell Biology
  • "Ferroptosis at the crossroads of infection, aging and cancer," 2020, Cancer Science
  • "CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles," 2021, Blood

Their research has been disseminated through frequent publication in a number of academic venues, including:

  • Free Radical Research
  • Archives of Biochemistry and Biophysics
  • Redox Biology
  • Cancer Science
  • Free Radical Biology and Medicine

Collaborative work features regularly in Toyokuni's portfolio, with frequent co-authors being Hiromasa Tanaka, Masaru Hori, Yashiro Motooka, Hiroaki Kajiyama, and Masaaki Mizuno. These recurring collaborations indicate ongoing research partnerships within their scientific network.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

    Brent R. Stockwell;José Pedro Friedmann Angeli;Hülya Bayir;Ashley I. Bush

  • Persistent oxidative stress in cancer

    Shinya Toyokuni;Keisei Okamoto;Junji Yodoi;Hiroshi Hiai

  • Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells

    Mito Kanatsu-Shinohara;Narumi Ogonuki;Kimiko Inoue;Hiromi Miki

  • Inhibition of gastric inhibitory polypeptide signaling prevents obesity.

    Kazumasa Miyawaki;Yuichiro Yamada;Nobuhiro Ban;Yu Ihara

  • Generation of Pluripotent Stem Cells from Neonatal Mouse Testis

    Mito Kanatsu-Shinohara;Kimiko Inoue;Jiyoung Lee;Momoko Yoshimoto

  • Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model

    S. Toyokuni;T. Tanaka;Y. Hattori;Y. Nishiyama

  • Reactive oxygen species-induced molecular damage and its application in pathology.

    Shinya Toyokuni

  • Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes.

    Y Ihara;S Toyokuni;K Uchida;H Odaka

  • Iron-induced carcinogenesis: the role of redox regulation.

    Shinya Toyokuni

  • Role of iron in carcinogenesis: cancer as a ferrotoxic disease.

    Shinya Toyokuni

  • Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

    Hirotaka Nagai;Yasumasa Okazaki;Shan Hwu Chew;Nobuaki Misawa

  • Long-Term Culture of Mouse Male Germline Stem Cells Under Serum-or Feeder-Free Conditions

    Mito Kanatsu-Shinohara;Hiromi Miki;Kimiko Inoue;Narumi Ogonuki

  • Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8-hydroxy-2′-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment

    Marina Erhola;Shinya Toyokuni;Kunihiko Okada;Tomoyuki Tanaka

  • 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules.

    Kunihiko Okada;Chantima Wangpoengtrakul;Toshihiko Osawa;Shinya Toyokuni

  • Contents of Endometriotic Cysts, Especially the High Concentration of Free Iron, Are a Possible Cause of Carcinogenesis in the Cysts through the Iron-Induced Persistent Oxidative Stress

    Ken Yamaguchi;Masaki Mandai;Shinya Toyokuni;Junzo Hamanishi

  • Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate

    Shinya Toyokuni;Koji Uchida;Keisei Okamoto;Yukari Hattori-Nakakuki

  • Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice

    Kunihiko Okada;Chantima Wangpoengtrakul;Tomoyuki Tanaka;Shinya Toyokuni

  • Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway.

    Kazuki Kuroda;Hua Han;Shoichi Tani;Kenji Tanigaki

  • CD9 Is a Surface Marker on Mouse and Rat Male Germline Stem Cells

    Mito Kanatsu-Shinohara;Shinya Toyokuni;Takashi Shinohara

Frequent Co-Authors

Hiroshi Hiai
Hiroshi Hiai Kyoto University
Fumitaka Kikkawa
Fumitaka Kikkawa Nagoya University
Koji Uchida
Koji Uchida University of Tokyo
Takashi Shinohara
Takashi Shinohara Kyoto University
Mito Kanatsu-Shinohara
Mito Kanatsu-Shinohara Kyoto University
Takashi Takahashi
Takashi Takahashi Nagoya University
Toshihiko Osawa
Toshihiko Osawa Nagoya University
Atsuo Ogura
Atsuo Ogura University of Tsukuba
Yoshitaka Sekido
Yoshitaka Sekido Nagoya University
Narumi Ogonuki
Narumi Ogonuki National Institutes of Health

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