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Biology and Biochemistry
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2026
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Genetics
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2026

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Genetics

D-Index
151
Citations
77969
World Ranking
133
National Ranking
69

Biology and Biochemistry

D-Index
153
Citations
79791
World Ranking
162
National Ranking
113

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2026 - Research.com Genetics in United States Leader Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2010 - US President's National Medal of Science "For his fundamental contributions to the development and use of transgenic mice. His research has provided experimental foundations and inspiration for progress in germline genetic modification in a range of species, which has generated a revolution in biology, medicine, and agriculture.", Presented by President Barack H. Obama in the East Room of the White House on Friday, October 21, 2011.
  • 2006 - Canada Gairdner International Award
  • 1992 - Fellow of the American Academy of Microbiology Genetics and Molecular Biology
  • 1989 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1987 - Member of the National Academy of Sciences
  • 1986 - Fellow of the American Academy of Arts and Sciences
  • 1986 - Member of the National Academy of Medicine (NAM)

Overview

Ralph L. Brinster is affiliated with the University of Pennsylvania in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Within these broader areas, their work concentrates on subfields such as Reproductive Medicine, Public Health, Environmental and Occupational Health, Molecular Biology, and Genetics.

The scientist's major topics of study include Reproductive Biology and Fertility, Sperm and Testicular Function, Renal and related cancers, Reproductive Health and Technologies, Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities, Single-cell and spatial transcriptomics, and Pluripotent Stem Cells Research.

Among their recent publications are:

  • FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling, 2020, Cell Proliferation
  • Roles of Stra8 and Tcerg1l in retinoic acid induced spermatogonial differentiation in mouse, 2021, Biology of Reproduction
  • Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity, 2022, PLoS Biology
  • Single-cell multiomic comparison of mouse and rat spermatogenesis reveals gene regulatory networks conserved for over 20 million years, 2025, Stem Cell Reports
  • Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver., 2020, UNC Libraries

Ralph L. Brinster has collaborated frequently with several co-authors, including Eoin C. Whelan, Mary R. Avarbock, Fan Yang, Daniel P. Beiting, and Hiroshi Kubota.

Their work has been published in venues such as Cell Proliferation, Biology of Reproduction, PLoS Biology, Stem Cell Reports, and UNC Libraries.

The scientist has received multiple awards and honors across their career. These include:

  • US President's National Medal of Science in 2010, presented by President Barack H. Obama for contributions to transgenic mice and genetic modification research
  • Canada Gairdner International Award, 2006
  • Fellow of the American Academy of Microbiology, 1992
  • Fellow of the American Association for the Advancement of Science (AAAS), 1989
  • Member of the National Academy of Sciences, 1987
  • Member of the National Academy of Medicine (NAM), 1986
  • Fellow of the American Academy of Arts and Sciences, 1986

Best Publications

  • The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

    J. M. Adams;A. W. Harris;C. A. Pinkert;L. M. Corcoran

  • SPERMATOGENESIS FOLLOWING MALE GERM-CELL TRANSPLANTATION

    Ralph L. Brinster;James W. Zimmermann

  • Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes

    Richard D. Palmiter;Ralph L. Brinster;Robert E. Hammer;Myrna E. Trumbauer

  • Germ-line transformation of mice

    Richard D. Palmiter;Ralph L. Brinster

  • Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs

    Ralph L. Brinster;Howard Y. Chen;Myrna E. Trumbauer;Mary K. Yagle

  • Germline transmission of donor haplotype following spermatogonial transplantation.

    Ralph L. Brinster;Mary R. Avarbock

  • Production of transgenic rabbits, sheep and pigs by microinjection

    Robert E. Hammer;Vernon G. Pursel;Caird E. Rexroad;Robert J. Wall

  • GROWTH FACTORS ESSENTIAL FOR SELF-RENEWAL AND EXPANSION OF MOUSE SPERMATOGONIAL STEM CELLS

    Hiroshi Kubota;Mary R. Avarbock;Ralph L. Brinster

  • Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

    Eric P. Sandgren;Noreen C. Luetteke;Richard D. Palmiter;Ralph L. Brinster

  • Metallothionein-human GH fusion genes stimulate growth of mice

    Richard D. Palmiter;Gunnar Norstedt;Richard E. Gelinas;Robert E. Hammer

  • Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs

    Ralph L. Brinster;Howard Y. Chen;Myrna Trumbauer;Allen W. Senear

  • Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

    Francis V. Chisari;Kathleen Klopchin;Takashi Moriyama;Claudio Pasquinelli

  • Replacement of diseased mouse liver by hepatic cell transplantation

    Jonathan A. Rhim;Eric P. Sandgren;Jay L. Degen;Richard D. Palmiter

  • β1- and α6-integrin are surface markers on mouse spermatogonial stem cells

    Takashi Shinohara;Mary R. Avarbock;Ralph L. Brinster

  • Transplantation of testis germinal cells into mouse seminiferous tubules.

    T Ogawa;J M Aréchaga;M R Avarbock;R L Brinster

  • Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium

    Brian A. Masters;Edward J. Kelly;Carol J. Quaife;Ralph L. Brinster

  • Heterologous introns can enhance expression of transgenes in mice.

    Richard D. Palmiter;Eric P. Sandgren;Mary R. Avarbock;D. Diane Allen

  • The effect of cells transferred into the mouse blastocyst on subsequent development.

    R. L. Brinster

  • Spermatogonial stem cells share some, but not all, phenotypic and functional characteristics with other stem cells.

    Hiroshi Kubota;Mary R. Avarbock;Ralph L. Brinster

  • Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

    Ralph L. Brinster;Howard Y. Chen;Albee Messing;Terry van Dyke

Frequent Co-Authors

Richard D. Palmiter
Richard D. Palmiter University of Washington
Mary R. Avarbock
Mary R. Avarbock University of Pennsylvania
Richard R. Behringer
Richard R. Behringer The University of Texas MD Anderson Cancer Center
David Lo
David Lo University of California, Riverside
Ursula Storb
Ursula Storb University of Chicago
Richard A. Flavell
Richard A. Flavell Yale University
Robert E. Hammer
Robert E. Hammer The University of Texas Southwestern Medical Center
Kyle E. Orwig
Kyle E. Orwig University of Pittsburgh
Albee Messing
Albee Messing University of Wisconsin–Madison
John W. Tobias
John W. Tobias University of Pennsylvania

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