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Biology and Biochemistry

D-Index
58
Citations
13019
World Ranking
13104
National Ranking
5587

Overview

Kyle E. Orwig is a researcher affiliated with the University of Pittsburgh in the United States. Their work predominantly focuses on fields within medicine and biochemistry, genetics, and molecular biology, with a strong emphasis on reproductive medicine, public health, molecular biology, genetics, and surgery.

The scientist's research interests cover a broad spectrum of topics related to reproductive biology and fertility, sperm and testicular function, reproductive health and technologies, and associated areas such as renal cancers, genetic and clinical aspects of sex determination and chromosomal abnormalities, ovarian function and disorders, and pluripotent stem cells research.

Kyle E. Orwig has contributed to multiple scholarly articles published in a range of venues. Frequent publication platforms include Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Fertility and Sterility, bioRxiv (Cold Spring Harbor Laboratory), Journal of Assisted Reproduction and Genetics, and Human Reproduction.

Some notable recent papers by Kyle E. Orwig include:

  • Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis, 2020, Developmental Cell
  • Single-cell analysis of human testis aging and correlation with elevated body mass index, 2022, Developmental Cell
  • Standardizing Risk Assessment for Treatment-Related Gonadal Insufficiency and Infertility in Childhood Adolescent and Young Adult Cancer: The Pediatric Initiative Network Risk Stratification System, 2020, Journal of Adolescent and Young Adult Oncology
  • Transcriptome profiling reveals signaling conditions dictating human spermatogonia fate in vitro, 2020, Proceedings of the National Academy of Sciences
  • Ovarian tissue cryopreservation as standard of care: what does this mean for pediatric populations?, 2020, Journal of Assisted Reproduction and Genetics

Kyle E. Orwig collaborates frequently with other researchers in their field. Regular co-authors include Meena Sukhwani, Sarah K. Munyoki, Amanda C. Zielen, Saher Sue Hammoud, and Jun Z. Li.

Best Publications

  • Essential role of Plzf in maintenance of spermatogonial stem cells

    José A Costoya;Robin M Hobbs;Maria Barna;Giorgio Cattoretti

  • Spermatogonial stem cell regulation and spermatogenesis

    Bart T. Phillips;Kathrin Gassei;Kyle E. Orwig

  • Spermatogonial stem cell enrichment by multiparameter selection of mouse testis cells.

    Takashi Shinohara;Kyle E. Orwig;Mary R. Avarbock;Ralph L. Brinster

  • Spermatogonial Stem Cell Transplantation into Rhesus Testes Regenerates Spermatogenesis Producing Functional Sperm

    Brian Peter Hermann;Meena Sukhwani;Felicity Winkler;Julia N. Pascarella

  • Transgenic mice produced by retroviral transduction of male germ-line stem cells.

    Makoto Nagano;Clayton J. Brinster;Kyle E. Orwig;Buom-Yong Ryu

  • Remodeling of the postnatal mouse testis is accompanied by dramatic changes in stem cell number and niche accessibility

    Takashi Shinohara;Kyle E. Orwig;Mary R. Avarbock;Ralph L. Brinster

  • Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal.

    Buom-Yong Ryu;Kyle E. Orwig;Jon M. Oatley;Mary R. Avarbock

  • Spermatogonial stem cells and spermatogenesis in mice, monkeys and men.

    Adetunji P. Fayomi;Kyle E. Orwig

  • Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells

    Charles A. Easley;Bart T. Phillips;Megan M. McGuire;Jennifer M. Barringer

  • Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring.

    Adetunji P. Fayomi;Karen Peters;Meena Sukhwani;Hanna Valli-Pulaski

  • GDNF Family Receptor alpha1 Phenotype of Spermatogonial Stem Cells in Immature Mouse Testes

    Anyanee Buageaw;Anyanee Buageaw;Meena Sukhwani;Ahmi Ben-Yehudah;Jens Ehmcke

  • Characterization, cryopreservation and ablation of spermatogonial stem cells in adult rhesus macaques

    Brian P. Hermann;Meena Sukhwani;Chih Cheng Lin;Yi Sheng

  • Restoration of fertility by germ cell transplantation requires effective recipient preparation.

    Clayton J. Brinster;Buom-Yong Ryu;Mary R. Avarbock;Levent Karagenc

  • Single-Cell RNA Sequencing of Human, Macaque, and Mouse Testes Uncovers Conserved and Divergent Features of Mammalian Spermatogenesis.

    Adrienne Niederriter Shami;Xianing Zheng;Sarah K. Munyoki;Qianyi Ma

  • SOHLH1 and SOHLH2 coordinate spermatogonial differentiation.

    Hitomi Suzuki;Hyo Won Ahn;Tianjiao Chu;Wayne Bowden

  • Spermatogonial stem cells in higher primates: are there differences from those in rodents?

    Brian P Hermann;Meena Sukhwani;Marc C Hansel;Kyle E Orwig

  • Phenotypic and functional characteristics of spermatogonial stem cells in rats.

    Buom-Yong Ryu;Kyle E. Orwig;Hiroshi Kubota;Mary R. Avarbock

  • Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques

    Brian P. Hermann;Meena Sukhwani;David R. Simorangkir;Tianjiao Chu

  • Cryopreservation and Transplantation of Spermatogonia and Testicular Tissue for Preservation of Male Fertility

    Kyle E Orwig;Stefan Schlatt

  • Restoration of Spermatogenesis in Infertile Mice by Sertoli Cell Transplantation

    Takashi Shinohara;Kyle E. Orwig;Mary R. Avarbock;Ralph L. Brinster

Frequent Co-Authors

Mary R. Avarbock
Mary R. Avarbock University of Pennsylvania
Michael J. Soares
Michael J. Soares University of Kansas
Ralph L. Brinster
Ralph L. Brinster University of Pennsylvania
Amander T. Clark
Amander T. Clark University of California, Los Angeles
Teresa K. Woodruff
Teresa K. Woodruff Northwestern University
Renee A. Reijo Pera
Renee A. Reijo Pera California Polytechnic State University
Gerald Schatten
Gerald Schatten University of Pittsburgh
Takashi Shinohara
Takashi Shinohara Kyoto University
Marvin L. Meistrich
Marvin L. Meistrich The University of Texas MD Anderson Cancer Center
Jun Li
Jun Li University of Oklahoma Health Sciences Center

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