Caryl E. Sortwell

Overview

Best Publications

• Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

  Katrina L. Paumier;Kelvin C. Luk;Fredric P. Manfredsson;Nicholas M. Kanaan

  430
  Citations

• Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

  Nicole K. Polinski;Laura A. Volpicelli-Daley;Caryl E. Sortwell;Kelvin C. Luk

  300
  Citations

• Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons

  Susan O McGuire;Zao Dung Ling;Jack W Lipton;Caryl E Sortwell

  290
  Citations

• A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease.

  P.M. Carvey;Z.D. Ling;C.E. Sortwell;M.R. Pitzer

  250
  Citations

• Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.

  Megan F Duffy;Timothy J Collier;Joseph R Patterson;Christopher J Kemp

  209
  Citations

• TRANSFER OF HOST-DERIVED ALPHA SYNUCLEIN TO GRAFTED DOPAMINERGIC NEURONS IN RAT

  Jeffrey H. Kordower;Hemraj B. Dodiya;Adam M. Kordower;Brian Terpstra

  194
  Citations

• Aging-related changes in the nigrostriatal dopamine system and the response to MPTP in nonhuman primates: Diminished compensatory mechanisms as a prelude to parkinsonism

  Timothy J. Collier;Jack Lipton;Brian F. Daley;Stephane Palfi

  190
  Citations

• Time course of apoptotic cell death within mesencephalic cell suspension grafts: implications for improving grafted dopamine neuron survival.

  Caryl E. Sortwell;Mark R. Pitzer;Timothy J. Collier

  178
  Citations

• Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.

  Jeffrey H. Kordower;Nicholas M. Kanaan;Yaping Chu;Rangasamy Suresh Babu

  171
  Citations

• Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss

  A.L. Spieles-Engemann;M.M. Behbehani;T.J. Collier;S.L. Wohlgenant

  148
  Citations

• Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex

  Anne L. Spieles-Engemann;Kathy Steece-Collier;Michael M. Behbehani;Timothy J. Collier

  119
  Citations

• α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.

  Tracy A. Cole;Hien Zhao;Timothy J. Collier;Ivette Sandoval

  119
  Citations

• Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats

  Eleonora Maries;Jeffrey H. Kordower;Yaping Chu;Timothy J. Collier

  117
  Citations

• Therapeutic potential of nerve growth factors in Parkinson's disease.

  Timothy J. Collier;Caryl E. Sortwell

  115
  Citations

• Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: an argument for neurotrophic supplementation.

  Timothy J. Collier;Caryl E. Sortwell;Brian F. Daley

  111
  Citations

• Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.

  Matthew J. Benskey;Rhyomi C. Sellnow;Ivette M. Sandoval;Ivette M. Sandoval;Caryl E. Sortwell;Caryl E. Sortwell

  104
  Citations

• Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System

  Sara E. Gombash;Sara E. Gombash;Fredric P. Manfredsson;Christopher J. Kemp;Nathan C. Kuhn

  104
  Citations

• Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils.

  Joseph R. Patterson;Megan F. Duffy;Christopher J. Kemp;Jacob W. Howe

  98
  Citations

• Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease

  Deanna M. Marchionini;Elin Lehrmann;Yaping Chu;Bin He

  92
  Citations

• Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats.

  Katherine E. Soderstrom;Jennifer A. O’Malley;Nathan D. Levine;Caryl E. Sortwell

  90
  Citations

• Angiogenic and neurotrophic effects of vascular endothelial growth factor (VEGF165): studies of grafted and cultured embryonic ventral mesencephalic cells

  Mark R Pitzer;Caryl E Sortwell;Brian F Daley;Susan O McGuire

  83
  Citations

• Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death.

  Caryl E. Sortwell;Brian F. Daley;Mark R. Pitzer;Susan O. McGuire

  82
  Citations