2026 Ole Isacson: Neuroscience Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Neuroscience	114	472	427	274	243	371	43364
Medicine	115	4593	4307	2494	2309	378	43640

Research.com Recognitions

2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Ole Isacson is affiliated with Harvard University in the United States and has a research focus spanning multiple areas within medicine, biochemistry, genetics, molecular biology, and neuroscience. Their work primarily addresses neurological disorders, with a significant emphasis on Parkinson's disease and related mechanisms.

The main fields of study for Ole Isacson include:

Medicine
Biochemistry, Genetics and Molecular Biology
Neuroscience

Within these fields, the subfields of study covered in Isacson's publications include:

Neurology
Physiology
Molecular Biology
Cellular and Molecular Neuroscience
Cell Biology

Key research topics explored by Ole Isacson are:

Parkinson's Disease Mechanisms and Treatments
Lysosomal Storage Disorders Research
Neuroinflammation and Neurodegeneration Mechanisms
Alzheimer's disease research and treatments
Cellular transport and secretion
Cholesterol and Lipid Metabolism
Nuclear Receptors and Signaling

Representative recent papers authored or co-authored by Ole Isacson include:

Cell type-specific lipid storage changes in Parkinson's disease patient brains are recapitulated by experimental glycolipid disturbance, 2020, Proceedings of the National Academy of Sciences
Advantages and Recent Developments of Autologous Cell Therapy for Parkinson's Disease Patients, 2020, Frontiers in Cellular Neuroscience
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice, 2020, Molecular Therapy - Nucleic Acids
Glycosphingolipid metabolism and its role in ageing and Parkinson's disease, 2021, Glycoconjugate Journal
Fibroblasts from idiopathic Parkinson's disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2, 2021, Molecular Brain

Ole Isacson frequently collaborates with a number of researchers, including:

Penelope J. Hallett
Ria Thomas
Kyle J. Connolly
Oeystein Roed Brekk
David A. Priestman

Their work has been published in venues such as:

Alzheimer s & Dementia
Scientific Reports
bioRxiv (Cold Spring Harbor Laboratory)
Proceedings of the National Academy of Sciences
Frontiers in Cellular Neuroscience

In recognition of their contributions to science, Ole Isacson was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Frank Soldner;Dirk Hockemeyer;Caroline Beard;Qing Gao

1945
Citations
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

Marius Wernig;Jian Ping Zhao;Jan Pruszak;Eva Hedlund

1681
Citations
Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

Lars M. Björklund;Rosario Sánchez-Pernaute;Sangmi Chung;Therese Andersson;Therese Andersson

1642
Citations
Specific MicroRNAs Modulate Embryonic Stem Cell–Derived Neurogenesis

Anna M. Krichevsky;Kai‐C. Sonntag;Ole Isacson;Kenneth S. Kosik

883
Citations
Altered Proteasomal Function in Sporadic Parkinson's Disease

Kevin St. P. McNaught;Roger Belizaire;Ole Isacson;Peter Jenner

821
Citations
Failure of the ubiquitin-proteasome system in Parkinson's disease.

Kevin St P. McNaught;Kevin St P. McNaught;C. Warren Olanow;Barry Halliwell;Ole Isacson

729
Citations
Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Gunnar Hargus;Oliver Cooper;Michela Deleidi;Adam Levy

574
Citations
Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

Terrence Deacon;James Schumacher;Jonathan Dinsmore;Christine Thomas

573
Citations
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

Oliver Cooper;Hyemyung Seo;Shaida Andrabi;Cristina Guardia-Laguarta

560
Citations
Dopamine neurons implanted into people with Parkinson’s disease survive without pathology for 14 years

Ivar Mendez;Angel Viñuela;Arnar Astradsson;Karim Mukhida

534
Citations
Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection

Chee Yeun Chung;Hyemyung Seo;Kai Christian Sonntag;Andrew Brooks

531
Citations
Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease

Ivar Mendez;Rosario Sanchez-Pernaute;Oliver Cooper;Angel Viñuela

505
Citations
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging.

F. Cicchetti;A. L. Brownell;K. Williams;Y. I. Chen

453
Citations
Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy

Chee Yeun Chung;James B. Koprich;Hasan Siddiqi;Ole Isacson

440
Citations
Functional neuronal replacement by grafted striatal neurones in the ibotenic acid-lesioned rat striatum

O. Isacson;P. Brundin;P. A. T. Kelly;P. A. T. Kelly;F. H. Gage

438
Citations
α-Synuclein-induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models.

Joseph R. Mazzulli;Joseph R. Mazzulli;Friederike Zunke;Ole Isacson;Lorenz Studer

407
Citations
Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival.

Brundin P;Isacson O;Björklund A

388
Citations
Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat

D M Frim;T A Uhler;W R Galpern;M F Beal

386
Citations
Proteasome inhibition causes nigral degeneration with inclusion bodies in rats

Kevin McNaught;Lars Björklund;Roger Belizaire;Ole Isacson

382
Citations
Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Penelope J. Hallett;Michela Deleidi;Arnar Astradsson;Gaynor A. Smith

379
Citations
Mechanisms of action of intracerebral neural implants: studies on nigral and striatal grafts to the lesioned striatum

Anders Björklund;Olle Lindvall;Ole Isacson;Patrik Brundin

374
Citations