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Biology and Biochemistry

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101
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1461
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830

Medicine

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101
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34097
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8044
National Ranking
4176

Overview

Clive N. Svendsen is affiliated with Cedars-Sinai Medical Center in the United States. Their research primarily spans the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these areas, they focus on subfields such as Molecular Biology, Neurology, Cellular and Molecular Neuroscience, Genetics, and Biomedical Engineering.

The main topics addressed in their work include:

  • Amyotrophic Lateral Sclerosis Research
  • Pluripotent Stem Cells Research
  • Neurogenetic and Muscular Disorders Research
  • CRISPR and Genetic Engineering
  • 3D Printing in Biomedical Research
  • Neurogenesis and neuroplasticity mechanisms
  • Retinal Development and Disorders

Recent papers authored or co-authored by Svendsen include:

  • "Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection" (2020, Cell Reports Medicine)
  • "Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery" (2020, Cell Stem Cell)
  • "G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD" (2020, Neuron)
  • "Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines" (2022, Nature Neuroscience)
  • "Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial" (2022, Nature Medicine)

Several frequent co-authors have collaborated extensively with Svendsen. These include Dhruv Sareen, Loren Ornelas, Michael J. Workman, Jeffrey D. Rothstein, and Maria G. Bañuelos.

The scientific outlets where Svendsen most regularly publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Medicine
  • Cell Stem Cell
  • Neuron
  • iScience

Best Publications

  • Induced pluripotent stem cells from a spinal muscular atrophy patient

    Allison D. Ebert;Junying Yu;Ferrill F. Rose;Virginia B. Mattis

  • Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

    Steven S Gill;Nikunj K Patel;Gary R Hotton;Karen O'Sullivan

  • Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

    Toby G Bush;Narman Puvanachandra;Catherine H Horner;Anabella Polito

  • Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

    Dhruv Sareen;Jacqueline G. O’Rourke;Pratap Meera;A. K. M. G. Muhammad

  • A new method for the rapid and long term growth of human neural precursor cells

    C. N. Svendsen;M. G. ter Borg;R. J. Armstrong;Anne Elizabeth Rosser

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease ☆

    Clive N. Svendsen;Maeve A. Caldwell;Jinkun Shen;Melanie G. ter Borg

  • Induced Pluripotent Stem Cells from Patients with Huntington’s Disease : Show CAG Repeat-Expansion-Associated Phenotypes

    Virginia B. Mattis;Soshana P. Svendsen;Allison Ebert;Clive N. Svendsen

  • Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

    V. G. Kimonides;N. H. Khatibi;C. N. Svendsen;M. V. Sofroniew

  • Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.

    Gad D. Vatine;Gad D. Vatine;Riccardo Barrile;Michael J. Workman;Samuel Sances

  • The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

    Alexandra B. Keenan;Sherry L. Jenkins;Kathleen M. Jagodnik;Simon Koplev

  • Growth factors regulate the survival and fate of cells derived from human neurospheres

    Maeve A Caldwell;Xiaoling He;Neil Wilkie;Scott Pollack

  • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study.

    Nikunj K. Patel;Martin Bunnage;Puneet Plaha;Clive N. Svendsen

  • Survival and Differentiation of Rat and Human Epidermal Growth Factor-Responsive Precursor Cells Following Grafting into the Lesioned Adult Central Nervous System

    C.N. Svendsen;D.J. Clarke;Anne Elizabeth Rosser;S.B. Dunnett

  • Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation

    Thor Ostenfeld;Maeve A. Caldwell;Karen R. Prowse;Maarten H. Linskens

  • Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.

    Robert H. Andres;Nobutaka Horie;William Slikker;Hadar Keren-Gill

  • GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS.

    Masatoshi Suzuki;Jacalyn McHugh;Craig Tork;Brandon Shelley

  • Human neural stem cells: isolation, expansion and transplantation.

    Clive N. Svendsen;Maeve A. Caldwell;Thor Ostenfeld

  • New prospects for human stem-cell therapy in the nervous system

    Clive N. Svendsen;Austin G. Smith

  • Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

Frequent Co-Authors

Alexander V. Ljubimov
Alexander V. Ljubimov Cedars-Sinai Medical Center
Leslie M. Thompson
Leslie M. Thompson University of California, Irvine
Stephen B. Dunnett
Stephen B. Dunnett Cardiff University
Anne Elizabeth Rosser
Anne Elizabeth Rosser Cardiff University
Steven Finkbeiner
Steven Finkbeiner University of California, San Francisco
Patrick Aebischer
Patrick Aebischer École Polytechnique Fédérale de Lausanne
Michael V. Sofroniew
Michael V. Sofroniew University of California, Los Angeles
Siddharthan Chandran
Siddharthan Chandran University of Edinburgh
Stephan R. Targan
Stephan R. Targan Cedars-Sinai Medical Center

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