Siddharthan Chandran

Research.com Recognitions

• 2018 - Fellow of the Royal Society of Edinburgh

Overview

Best Publications

• Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

  James Robert Tollervey;Tomaž Curk;Boris Rogelj;Michael Briese

  1196
  Citations

• A new method for the rapid and long term growth of human neural precursor cells

  C. N. Svendsen;M. G. ter Borg;R. J. Armstrong;Anne Elizabeth Rosser

  778
  Citations

• Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

  Peter Connick;Madhan Kolappan;Charles Crawley;Daniel J Webber

  723
  Citations

• Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  700
  Citations

• Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

  Nael H. Alami;Rebecca B. Smith;Monica A. Carrasco;Luis A. Williams

  666
  Citations

• Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

  Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  646
  Citations

• Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

  Sami J Barmada;Andrea Serio;Arpana Arjun;Bilada Bilican

  442
  Citations

• Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

  Bilada Bilican;Andrea Serio;Sami J. Barmada;Agnes Lumi Nishimura

  399
  Citations

• Oligodendrocytes Promote Neuronal Survival and Axonal Length by Distinct Intracellular Mechanisms: A Novel Role for Oligodendrocyte-Derived Glial Cell Line-Derived Neurotrophic Factor

  Alastair Wilkins;Henry Majed;Robert Layfield;Alastair Compston

  394
  Citations

• Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

  Andrea Serio;Bilada Bilican;Sami J. Barmada;Dale Michael Ando

  382
  Citations

• Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis.

  Peter L. Foley;Hanna M. Vesterinen;Barry J. Laird;Emily S. Sena

  337
  Citations

• Modeling ALS with motor neurons derived from human induced pluripotent stem cells.

  Samuel Sances;Lucie I. Bruijn;Siddharthan Chandran;Kevin Eggan

  326
  Citations

• Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

  Philip Hasel;Owen Dando;Owen Dando;Zoeb Jiwaji;Paul Baxter

  308
  Citations

• Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability

  Anna Claire Devlin;Karen Burr;Shyamanga Borooah;Joshua D. Foster

  308
  Citations

• Robust, Persistent Transgene Expression in Human Embryonic Stem Cells Is Achieved with AAVS1-Targeted Integration

  Joseph R. Smith;Joseph R. Smith;Sean Maguire;Lesley A. Davis;Lesley A. Davis;Morgan Alexander;Morgan Alexander

  291
  Citations

• FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA

  Tomohiro Yamazaki;Shi Chen;Yong Yu;Biao Yan

  286
  Citations

• Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells

  Alexis Joannides;Phil Gaughwin;Christof Schwiening;Henry Majed

  252
  Citations

• Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

  Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

  13
  Citations

• Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

  Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

  8
  Citations

• Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms

  Alastair Wilkins;Henry Majed;Robert Layfield;Alastair Compston

  1
  Citations