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Neuroscience

D-Index
54
Citations
10949
World Ranking
4912
National Ranking
415

Overview

David J. A. Wyllie is affiliated with the University of Edinburgh in the United Kingdom. Their research primarily spans the fields of Neuroscience and Biochemistry, Genetics and Molecular Biology, with a significant focus on various subfields such as Cellular and Molecular Neuroscience, Genetics, Molecular Biology, Cognitive Neuroscience, and Neurology.

The scientist's work covers a range of topics including Neuroscience and Neuropharmacology Research, Genetics and Neurodevelopmental Disorders, Autism Spectrum Disorder Research, Neuroinflammation and Neurodegeneration Mechanisms, Neurogenesis and Neuroplasticity mechanisms, Receptor Mechanisms and Signaling, as well as Amyotrophic Lateral Sclerosis Research.

Among their recent publications are several notable papers:

  • Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome, 2020, Cell Reports
  • Altered network properties in C9ORF72 repeat expansion cortical neurons are due to synaptic dysfunction, 2021, Molecular Neurodegeneration
  • NMDA receptor function in inhibitory neurons, 2021, Neuropharmacology
  • Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns, 2020, Molecular Autism
  • Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus, 2025, Nature Neuroscience

The scientist frequently publishes in journals such as Cell Reports, Molecular Autism, and Neuropharmacology, with multiple appearances in leading venues including bioRxiv and Brain Communications.

Collaborations have been a significant part of their career. Frequent coauthors include Peter C. Kind, Sam A. Booker, Sumantra Chattarji, Giles E. Hardingham, and Owen Dando.

Best Publications

  • Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus

    T. Manabe;D. J. A. Wyllie;D. J. Perkel;R. A. Nicoll

  • Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

    Sofia Papadia;Francesc X Soriano;Frédéric Léveillé;Marc-Andre Martel

  • Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles

    Kevin Erreger;Shashank M. Dravid;Tue G. Banke;David J. A. Wyllie

  • Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

    Bilada Bilican;Andrea Serio;Sami J. Barmada;Agnes Lumi Nishimura

  • Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.

    Philip Hasel;Owen Dando;Owen Dando;Zoeb Jiwaji;Paul Baxter

  • Influence of GluN2 subunit identity on NMDA receptor function

    D.J.A. Wyllie;M.R. Livesey;G.E. Hardingham

  • Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors.

    David J. A. Wyllie;Philippe Béhé;David Colquhoun

  • Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals

    Jing-Dan Qiu;Yan-Wei Tan;Anna M. Hagenston;Marc-André Martel

  • Identification of Amino Acid Residues of the NR2A Subunit That Control Glutamate Potency in Recombinant NR1/NR2A NMDA Receptors

    Lesley C. Anson;Philip E. Chen;David J. A. Wyllie;David Colquhoun

  • Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

    Philip E Chen;Matthew T Geballe;Phillip J Stansfeld;Alexander R Johnston

  • GRIN2A-related disorders : genotype and functional consequence predict phenotype

    Vincent Strehlow;Henrike O Heyne;Henrike O Heyne;Henrike O Heyne;Danique R M Vlaskamp;Katie F M Marwick

  • Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors.

    Philippe BEhe;Peter Stern;David J. A. Wyllie;Mohammed Nassar

  • Glutamate receptor gating.

    Kevin Erreger;Philip E Chen;David J A Wyllie;Stephen F Traynelis

  • The Subtype of GluN2 C-terminal Domain Determines the Response to Excitotoxic Insults

    Marc-André Martel;Tomás J Ryan;Tomás J Ryan;Karen F.S. Bell;Jill H Fowler

  • Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors

    Kevin Erreger;Matthew T Geballe;Anders S Kristensen;Philip E Chen

  • Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

    Karen F. S. Bell;Bashayer Al-Mubarak;Marc André Martel;Sean McKay

  • C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

    Bhuvaneish T. Selvaraj;Matthew R. Livesey;Chen Zhao;Jenna M. Gregory

  • Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

    Emma L Clayton;Nancy Sue;Karen J Smillie;Timothy O'Leary

  • Specific Targeting of Pro-Death NMDA Receptor Signals with Differing Reliance on the NR2B PDZ Ligand

    Francesc X. Soriano;Marc-Andre Martel;Sofia Papadia;Anne Vaslin

  • Suppression of the Intrinsic Apoptosis Pathway by Synaptic Activity

    Frédéric Léveillé;Sofia Papadia;Michael Fricker;Karen F. S. Bell

  • Activation of glutamate receptors and glutamate uptake in identified macroglial cells in rat cerebellar cultures.

    D. J. A. Wyllie;A. Mathie;C. J. Symonds;S. G. Cull-Candy

Frequent Co-Authors

Giles E. Hardingham
Giles E. Hardingham University of Edinburgh
Peter C. Kind
Peter C. Kind University of Edinburgh
Sumantra Chattarji
Sumantra Chattarji National Centre for Biological Sciences
Seth G. N. Grant
Seth G. N. Grant University of Edinburgh
Stuart G. Cull-Candy
Stuart G. Cull-Candy University College London
Emma R. Wood
Emma R. Wood University of Edinburgh
Douglas Blackwood
Douglas Blackwood University of Edinburgh
John T.R. Isaac
John T.R. Isaac Johnson & Johnson (United States)
Jeffrey D. Rothstein
Jeffrey D. Rothstein Johns Hopkins University
Christopher Shaw
Christopher Shaw King's College London

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