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Molecular Biology

D-Index
76
Citations
35020
World Ranking
1131
National Ranking
587

Research.com Recognitions

  • 2006 - Fellow of the MacArthur Foundation

Overview

Kevin Eggan is affiliated with Harvard University in the United States. Their research spans multiple fields including biochemistry, genetics, molecular biology, and medicine.

The main subfields of study in their work include molecular biology, neurology, genetics, cellular and molecular neuroscience, and immunology. The primary topics Kevin Eggan investigates cover amyotrophic lateral sclerosis research, CRISPR and genetic engineering, pluripotent stem cells research, single-cell and spatial transcriptomics, neurogenetic and muscular disorders research, neuroinflammation and neurodegeneration mechanisms, and virus-based gene therapy research.

Kevin Eggan has published extensively, with frequent contributions in a number of scientific venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Cell Stem Cell, Neuron, and Cell Reports.

Notable recent papers authored or co-authored by Kevin Eggan include:

  • "C9orf72 suppresses systemic and neural inflammation induced by gut bacteria" (2020, Nature)
  • "Evaluating the state of the science for adeno-associated virus integration: An integrated perspective" (2022, Molecular Therapy)
  • "Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues" (2022, Nature Communications)
  • "Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis" (2020, JAMA Neurology)
  • "Exposure of iPSC-derived human microglia to brain substrates enables the generation and manipulation of diverse transcriptional states in vitro" (2023, Nature Immunology)

Frequent co-authors who have collaborated with Kevin Eggan include Steven A. McCarroll, Francesco Limone, Sulagna Ghosh, Greta Pintacuda, and Ralda Nehme.

Among their accolades, Kevin Eggan was named a Fellow of the MacArthur Foundation in 2006.

Best Publications

  • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.

    John T. Dimos;Kit T. Rodolfa;Kathy K. Niakan;Laurin M. Weisenthal

  • Somatic coding mutations in human induced pluripotent stem cells

    Athurva Gore;Zhe Li;Ho Lim Fung;Jessica E. Young

  • Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells

    Chad A. Cowan;Jocelyn Atienza;Douglas A. Melton;Kevin Eggan

  • Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines

    Christoph Bock;Evangelos Kiskinis;Evangelos Kiskinis;Griet Verstappen;Griet Verstappen;Hongcang Gu

  • Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model.

    Francesco Paolo Di Giorgio;Monica A Carrasco;Michelle C Siao;Tom Maniatis

  • Derivation of embryonic germ cells and male gametes from embryonic stem cells

    Niels Geijsen;Melissa Horoschak;Melissa Horoschak;Kitai Kim;Kitai Kim;Joost Gribnau

  • Nuclear Cloning and Epigenetic Reprogramming of the Genome

    William M. Rideout;Kevin Eggan;Rudolf Jaenisch

  • Epigenetic Instability in ES Cells and Cloned Mice

    David Humpherys;Kevin Eggan;Hidenori Akutsu;Konrad Hochedlinger

  • A Small Molecule Inhibitor of Tgf-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog

    Justin K. Ichida;Joel Blanchard;Kelvin Lam;Esther Y. Son

  • Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

    Kevin Eggan;Hidenori Akutsu;Janet Loring;Laurie Jackson-Grusby

  • Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

    Esther Y. Son;Justin K. Ichida;Justin K. Ichida;Brian J. Wainger;Brian J. Wainger;Jeremy S. Toma

  • Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

    Brian J. Wainger;Evangelos Kiskinis;Cassidy Mellin;Ole Wiskow

  • Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells

    Asif M Maroof;Sotirios Keros;Jennifer Tyson;Shui-Wang Ying

  • Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

    Nael H. Alami;Rebecca B. Smith;Monica A. Carrasco;Luis A. Williams

  • DNA methylation dynamics of the human preimplantation embryo

    Zachary D. Smith;Michelle M. Chan;Kathryn C. Humm;Rahul Karnik

  • Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming

    Jie Deng;Robert Shoemaker;Bin Xie;Athurva Gore

  • Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

    Alex Bortvin;Kevin Eggan;Helen Skaletsky;Helen Skaletsky;Hidenori Akutsu

  • A functionally characterized test set of human induced pluripotent stem cells

    Gabriella L Boulting;Evangelos Kiskinis;Evangelos Kiskinis;Gist F Croft;Mackenzie W Amoroso

  • Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

    Francesco Paolo Di Giorgio;Gabriella L. Boulting;Samuel Bobrowicz;Kevin C. Eggan

  • Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

    David Humpherys;Kevin Eggan;Hidenori Akutsu;Adam Friedman

Frequent Co-Authors

Steven A. McCarroll
Steven A. McCarroll Harvard University
Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Robert E. Handsaker
Robert E. Handsaker Harvard University
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Benjamin M. Neale
Benjamin M. Neale Harvard University
Dieter Egli
Dieter Egli Columbia University
Douglas A. Melton
Douglas A. Melton Harvard University
Christoph Bock
Christoph Bock Austrian Academy of Sciences
Mark J. Daly
Mark J. Daly Massachusetts General Hospital

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