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Hans R. Schöler

Hans R. Schöler

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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
113
Citations
55996
World Ranking
327
National Ranking
29

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2008 - Robert Koch Prize

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Cellular differentiation

His scientific interests lie mostly in Cell biology, Stem cell, Molecular biology, Embryonic stem cell and Cellular differentiation. His Cell biology research is multidisciplinary, incorporating perspectives in Reprogramming, SOX2 and Cell potency, Homeobox protein NANOG, Induced pluripotent stem cell. His Stem cell study combines topics in areas such as Cell and Adult stem cell, Induced stem cells, Embryoid body.

His study in Molecular biology is interdisciplinary in nature, drawing from both POU domain, Enhancer, Transcription factor, Oct-4 and Germ cell. His Embryonic stem cell research includes elements of Embryo, Germline and Blastocyst. His study looks at the relationship between Cellular differentiation and topics such as Inner cell mass, which overlap with Cre-Lox recombination and Gene targeting.

His most cited work include:

  • Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 (2907 citations)
  • Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins (1735 citations)
  • DERIVATION OF OOCYTES FROM MOUSE EMBRYONIC STEM CELLS (934 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Cell biology, Induced pluripotent stem cell, Reprogramming, Embryonic stem cell and Stem cell. The concepts of his Cell biology study are interwoven with issues in Genetics, Cellular differentiation, Somatic cell and SOX2, Transcription factor. He interconnects Neuroscience, Bioinformatics and Neural stem cell in the investigation of issues within Induced pluripotent stem cell.

His Reprogramming research focuses on Chromatin and how it connects with Histone. His Embryonic stem cell research includes themes of Molecular biology, Inner cell mass and Embryo. His work deals with themes such as KOSR, Embryoid body, Adult stem cell and Germ line development, Germ cell, which intersect with Stem cell.

He most often published in these fields:

  • Cell biology (87.50%)
  • Induced pluripotent stem cell (57.63%)
  • Reprogramming (52.54%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cell biology (87.50%)
  • Induced pluripotent stem cell (57.63%)
  • Reprogramming (52.54%)

In recent papers he was focusing on the following fields of study:

Hans R. Schöler mostly deals with Cell biology, Induced pluripotent stem cell, Reprogramming, Transcription factor and SOX2. Hans R. Schöler has included themes like Embryonic stem cell, Cellular differentiation, DNA methylation, Somatic cell and Chromatin in his Cell biology study. His studies deal with areas such as Molecular biology, Stem cell, Neural stem cell, Skeletal muscle and Drug discovery as well as Induced pluripotent stem cell.

His Stem cell research is multidisciplinary, incorporating elements of Cancer research and Phenotypic screening. His Reprogramming study integrates concerns from other disciplines, such as POU domain, Ectopic expression, Enhancer, OLIG2 and Epigenetics. Germline is closely connected to In vitro in his research, which is encompassed under the umbrella topic of Transcription factor.

Between 2016 and 2021, his most popular works were:

  • Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. (100 citations)
  • Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. (100 citations)
  • Genome-wide tracking of dCas9-methyltransferase footprints. (64 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Genetics

Hans R. Schöler mainly focuses on Cell biology, Induced pluripotent stem cell, Reprogramming, SOX2 and Stem cell. His Cell biology study incorporates themes from Enhancer, Transcription factor, Chromatin, OLIG2 and Regulation of gene expression. His Induced pluripotent stem cell research incorporates themes from Intron, Skeletal muscle, Drug discovery and Neural stem cell.

In Neural stem cell, Hans R. Schöler works on issues like Neuroscience, which are connected to Cellular differentiation. His Reprogramming research is multidisciplinary, relying on both KLF4 and Epigenetics. His biological study spans a wide range of topics, including Human Induced Pluripotent Stem Cells, Cancer research, Tissue therapy and Allele.

Best Publications

  • Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

    Jennifer Nichols;Branko Zevnik;Konstantinos Anastassiadis;Hitoshi Niwa

  • Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

    Hongyan Zhou;Shili Wu;Jin Young Joo;Saiyong Zhu

  • DERIVATION OF OOCYTES FROM MOUSE EMBRYONIC STEM CELLS

    Karin Hübner;Guy Fuhrmann;Lane K. Christenson;James Kehler

  • Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

    Jeong Beom Kim;Holm Zaehres;Guangming Wu;Luca Gentile

  • Oct4-induced pluripotency in adult neural stem cells

    Jeong Beom Kim;Vittorio Sebastiano;Guangming Wu;Marcos J. Araúzo-Bravo

  • Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds

    Yan Shi;Caroline Desponts;Jeong Tae Do;Heung Sik Hahm

  • Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells

    Young Il Yeom;Guy Fuhrmann;Catherine E. Ovitt;Alexander Brehm

  • Oct-4: gatekeeper in the beginnings of mammalian development.

    Maurizio Pesce;Hans R. Schöler

  • A combined chemical and genetic approach for the generation of induced pluripotent stem cells.

    Yan Shi;Jeong Tae Do;Caroline Desponts;Heung Sik Hahm

  • New type of POU domain in germ line-specific protein Oct-4.

    Hans R. Schöler;Siegfried Ruppert;Noriaki Suzuki;Kamal Chowdhury

  • Direct reprogramming of human neural stem cells by OCT4

    Jeong Beom Kim;Boris Greber;Marcos J. Araúzo-Bravo;Johann Meyer

  • Regulatory networks in embryo-derived pluripotent stem cells.

    Michele Boiani;Hans R. Schöler

  • A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor.

    H. R. Scholer;A. K. Hatzopoulos;Rudi Balling;N. Suzuki

  • Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

    Susan L. Palmieri;Werner Peter;Heike Hess;Hans R. Schöler

  • Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.

    Hans R. Schöler;Gregory R. Dressler;Rudi Balling;Heidi Rohdewohld

  • Oct4 is required for primordial germ cell survival

    James Kehler;Elena Tolkunova;Birgit Koschorz;Maurizio Pesce

  • Oct4 distribution and level in mouse clones: consequences for pluripotency

    Michele Boiani;Sigrid Eckardt;Hans R. Schöler;K. John McLaughlin

  • Direct reprogramming of fibroblasts into neural stem cells by defined factors.

    Dong Wook Han;Dong Wook Han;Natalia Tapia;Andreas Hermann;Kathrin Hemmer

  • Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation

    Maurizio Pesce;Xiangyuan Wang;Debra J Wolgemuth;Hans R Schöler

  • Generation of Induced Pluripotent Stem Cells from Human Cord Blood

    Alexandra Haase;Ruth Olmer;Kristin Schwanke;Stephanie Wunderlich

Frequent Co-Authors

Herbert Waldmann
Herbert Waldmann Max Planck Society
Peter Gruss
Peter Gruss Okinawa Institute of Science and Technology
Martin Zenke
Martin Zenke RWTH Aachen University
Matthias Wilmanns
Matthias Wilmanns Universität Hamburg
Hossein Baharvand
Hossein Baharvand Royan Institute
Axel Schambach
Axel Schambach Hannover Medical School
Hyung-Min Chung
Hyung-Min Chung Konkuk University
Sheng Ding
Sheng Ding Tsinghua University

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