World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
83
Citations
22741
World Ranking
908
National Ranking
74

Overview

Axel Schambach is affiliated with Hannover Medical School in Germany and has an extensive research portfolio focusing on biochemistry, genetics, and molecular biology. Their scholarly work spans over 200 publications, with significant contributions also in medicine.

Schambach's research interests cover a range of subfields including molecular biology, oncology, immunology, genetics, and physiology. A key focus area is CAR-T cell therapy research, which accounts for 116 publications. They also have a substantial number of works related to CRISPR and genetic engineering, virus-based gene therapy research, immune cell function and interaction, pluripotent stem cells research, viral infectious diseases and gene expression in insects, as well as RNA interference and gene delivery.

The frequent venues where Schambach's research is published include Frontiers in Immunology, Human Gene Therapy, bioRxiv (Cold Spring Harbor Laboratory), Molecular Therapy, and Blood. These journals highlight a consistent presence in both immunology and gene therapy fields.

Recent notable papers authored or coauthored by Schambach include:

  • Betibeglogene Autotemcel Gene Therapy for Non-β 00 Genotype β-Thalassemia, 2021, New England Journal of Medicine
  • Cell transcriptomic atlas of the non-human primate Macaca fascicularis, 2022, Nature
  • Use of Cell and Genome Modification Technologies to Generate Improved "Off-the-Shelf" CAR T and CAR NK Cells, 2020, Frontiers in Immunology
  • Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model, 2021, Journal of Hepatology
  • Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis, 2022, Nature Communications

Their research collaborations include frequent coauthors such as Michael Morgan with 44 joint publications, Michael Rothe with 30, Adrian Schwarzer with 16, Katharina Zimmermann with 14, and Hildegard Büning with 12.

Best Publications

  • Skin tissue generation by laser cell printing.

    Lothar Koch;Andrea Deiwick;Sabrina Schlie;Stefanie Michael

  • Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity

    Christian Jörg Braun;Kaan Boztug;Anna Paruzynski;Maximilian Witzel

  • Insertional Transformation of Hematopoietic Cells by Self-inactivating Lentiviral and Gammaretroviral Vectors

    Ute Modlich;Susana Navarro;Daniela Zychlinski;Tobias Maetzig

  • A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Sung Yun Pai;H. Bobby Gaspar;Myriam Armant

  • A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.

    Jianwei Wang;Qian Sun;Yohei Morita;Hong Jiang

  • Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

    Ute Modlich;Jens Bohne;Manfred Schmidt;Christof von Kalle

  • Long noncoding RNA Chast promotes cardiac remodeling.

    Janika Viereck;Regalla Kumarswamy;Ariana Foinquinos;Ke Xiao

  • Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors

    Daniela Zychlinski;Axel Schambach;Ute Modlich;Tobias Maetzig

  • Gene therapy on the move

    Kerstin B. Kaufmann;Hildegard Büning;Anne Galy;Axel Schambach;Axel Schambach

  • The phenotype of human STK4 deficiency

    Hengameh Abdollahpour;Giridharan Appaswamy;Daniel Kotlarz;Daniel Kotlarz;Jana Diestelhorst;Jana Diestelhorst

  • Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming

    Eva Warlich;Johannes Kuehle;Tobias Cantz;Tobias Cantz;Martijn H Brugman

  • Gammaretroviral vectors: biology, technology and application.

    Tobias Maetzig;Melanie Galla;Christopher Baum;Axel Schambach

  • Advantages and applications of CAR-expressing natural killer cells.

    Wolfgang Glienke;Ruth Esser;Christoph Priesner;Julia D. Suerth

  • Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

    Daniel Kotlarz;Natalia Ziętara;Gulbu Uzel;Thomas Weidemann

  • Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications.

    Maurice Labuhn;Felix F. Adams;Michelle Ng;Sabine Knoess

  • NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD + –sirtuin-1–dependent pathway

    Julia Skokowa;Dan Lan;Basant Kumar Thakur;Fei Wang

  • Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy.

    Eirini P Papapetrou;Axel Schambach;Axel Schambach

  • Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

    Axel Schambach;Harald Wodrich;Markus Hildinger;Jens Bohne

  • LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia

    Julia Skokowa;Gunnar Cario;Murat Uenalan;Axel Schambach

  • Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies

    Nico Lachmann;Mania Ackermann;Eileen Frenzel;Steffi Liebhaber

Frequent Co-Authors

Christopher Baum
Christopher Baum Charité - University Medicine Berlin
Adrian J. Thrasher
Adrian J. Thrasher University College London
David A. Williams
David A. Williams Boston Children's Hospital
Doris Steinemann
Doris Steinemann Hannover Medical School
Brigitte Schlegelberger
Brigitte Schlegelberger Hannover Medical School
Gudrun Göhring
Gudrun Göhring Hannover Medical School
Hans R. Schöler
Hans R. Schöler Max Planck Society
Fulvio Mavilio
Fulvio Mavilio University of Modena and Reggio Emilia
Ulrich Martin
Ulrich Martin Hannover Medical School
Ulrike Koehl
Ulrike Koehl Leipzig University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

A background in Molecular Biology opens doors to a wide range of online graduate programs and diverse careers. Graduates can build upon their scientific foundation by pursuing advanced studies in fields such as counseling, psychology, and mental health. These areas offer high-impact career opportunities for those interested in both research and helping others.

For example, some molecular biology graduates transition into health services by enrolling in a master of mental health online program. Others leverage their background in life sciences along with specialized training to explore what can you do with a masters in forensic psychology, contributing to criminal investigations or legal proceedings.

Many online programs are tailored for working professionals, making it feasible to earn a masters in child psychology online, or to explore a variety of online masters degrees in counseling. These programs complement a molecular biology education by broadening your expertise and expanding your career options in healthcare, education, forensics, and wellness.

Best Scientists Citing Axel Schambach

Trending Scientists