D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Immunology
France
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 157 Citations 91,580 563 World Ranking 21 National Ranking 2
Medicine D-index 168 Citations 108,393 739 World Ranking 206 National Ranking 5
Best Scientists D-index 176 Citations 125,470 847 World Ranking 496 National Ranking 6

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2022 - Research.com Medicine in France Leader Award

2022 - Research.com Immunology in France Leader Award

2019 - Member of the National Academy of Sciences

2017 - Member of the National Academy of Medicine (NAM)

2016 - Presidential Award, Clinical Immunology Society

2015 - Japan Prize for the proposal of the concept of gene therapy and its clinical applications.

2014 - Robert Koch Prize

2000 - Grand Prix scientifique de la Fondation NRJ, Institut de France

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Immune system

Alain Fischer focuses on Immunology, Immunodeficiency, Transplantation, Severe combined immunodeficiency and Internal medicine. In most of his Immunology studies, his work intersects topics such as Genetic enhancement. His studies deal with areas such as Ectodermal dysplasia, Phenotype, X-linked lymphoproliferative disease, Nonsense mutation and ORAI1 as well as Immunodeficiency.

Alain Fischer has included themes like Stem cell and Histocompatibility in his Transplantation study. His Severe combined immunodeficiency research is multidisciplinary, incorporating perspectives in Cancer research, Disease, Bone marrow and Virology. His studies in Internal medicine integrate themes in fields like Gastroenterology, Endocrinology and Surgery.

His most cited work include:

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. (3006 citations)
  • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease (2298 citations)
  • A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency (1589 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Immunology, Transplantation, Severe combined immunodeficiency, Immunodeficiency and Hematopoietic stem cell transplantation. His research in Immunology intersects with topics in Genetic enhancement and Stem cell. The concepts of his Genetic enhancement study are interwoven with issues in Combined immunodeficiencies and Bioinformatics.

The Severe combined immunodeficiency study combines topics in areas such as Cancer research, Bone marrow and Virology. His study focuses on the intersection of T cell and fields such as Molecular biology with connections in the field of Cytotoxic T cell, Somatic hypermutation, DNA repair, Genetics and Immunoglobulin class switching. The various areas that Alain Fischer examines in his Immune system study include Gene and Lymphocyte.

He most often published in these fields:

  • Immunology (74.70%)
  • Transplantation (20.88%)
  • Severe combined immunodeficiency (21.22%)

What were the highlights of his more recent work (between 2016-2021)?

  • Immunology (74.70%)
  • Immune system (17.79%)
  • Pediatrics (7.18%)

In recent papers he was focusing on the following fields of study:

Alain Fischer spends much of his time researching Immunology, Immune system, Pediatrics, T cell and Internal medicine. His research investigates the connection between Immunology and topics such as Phenotype that intersect with problems in Mutation. As a part of the same scientific family, Alain Fischer mostly works in the field of Immune system, focusing on Myeloid and, on occasion, Common variable immunodeficiency.

Alain Fischer has researched Pediatrics in several fields, including Hematopoietic stem cell transplantation, Hemophagocytic lymphohistiocytosis, Retrospective cohort study, Intensive care and Primary immunodeficiency. His research in Hematopoietic stem cell transplantation tackles topics such as Severe combined immunodeficiency which are related to areas like Stem cell. His T cell research incorporates themes from B cell, Cancer research, Cell growth and Germline.

Between 2016 and 2021, his most popular works were:

  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. (689 citations)
  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. (689 citations)
  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. (689 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Immune system

Alain Fischer mainly investigates Immunology, Immune system, T cell, Internal medicine and Interferon. Immunology and Germline mutation are commonly linked in his work. His work deals with themes such as Osteopetrosis, Hematopoietic stem cell and Single Center, which intersect with Immune system.

His T cell research is multidisciplinary, relying on both Cancer research, X-linked severe combined immunodeficiency, Genetic enhancement, Progenitor cell and Lymphocyte. His biological study spans a wide range of topics, including Gene mutation and Copy-number variation. Alain Fischer focuses mostly in the field of Interferon, narrowing it down to topics relating to Tumor necrosis factor alpha and, in certain cases, Alpha interferon, Viral load, Interleukin 6, Inflammation and Chemokine.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack.
Science (2003)

4057 Citations

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

Marina Cavazzana-Calvo;Salima Hacein-Bey;Geneviève De Saint Basile;Fabian Gross.
Science (2000)

3209 Citations

A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency

Salima Hacein-Bey-Abina;Christof Von Kalle;Manfred Schmidt;Françoise Le Deist.
The New England Journal of Medicine (2003)

2200 Citations

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

F. Rieux-Laucat;F. Le Deist;C. Hivroz;I. A. G. Roberts.
Science (1995)

1864 Citations

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

Patrick Revy;Taro Muto;Yves Levy;Frédéric Geissmann.
Cell (2000)

1714 Citations

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

Salima Hacein-Bey-Abina;Alexandrine Garrigue;Gary P. Wang;Jean Soulier.
Journal of Clinical Investigation (2008)

1714 Citations

Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

Nathalie Cartier;Salima Hacein-Bey-Abina;Cynthia C. Bartholomae;Gabor Veres.
Science (2009)

1456 Citations

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

Susan E. Stepp;Rémi Dufourcq-Lagelouse;Françoise Le Deist;Françoise Le Deist;Sadhna Bhawan.
Science (1999)

1366 Citations

Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy

Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud.
The New England Journal of Medicine (2002)

1350 Citations

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Marina Cavazzana-Calvo;Emmanuel Payen;Olivier Negre;Gary Wang.
Nature (2010)

1326 Citations

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