World's Best Scientists 2026 revealed!
Alain Fischer

Alain Fischer

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Best Scientists
2025
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Immunology
France
2026

D-Index & Metrics

Best Scientists

D-Index
173
Citations
118870
World Ranking
775
National Ranking
14

Immunology

D-Index
176
Citations
122975
World Ranking
42
National Ranking
2

Medicine

D-Index
177
Citations
123290
World Ranking
404
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Immunology in France Leader Award
  • 2026 - Research.com Medicine in France Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Immunology in France Leader Award
  • 2025 - Research.com Medicine in France Leader Award
  • 2023 - Research.com Immunology in France Leader Award
  • 2023 - Research.com Medicine in France Leader Award
  • 2022 - Research.com Immunology in France Leader Award
  • 2022 - Research.com Medicine in France Leader Award
  • 2019 - Member of the National Academy of Sciences
  • 2017 - Member of the National Academy of Medicine (NAM)
  • 2016 - Presidential Award, Clinical Immunology Society
  • 2015 - Japan Prize for the proposal of the concept of gene therapy and its clinical applications.
  • 2014 - Robert Koch Prize
  • 2000 - Grand Prix scientifique de la Fondation NRJ, Institut de France
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Alain Fischer is affiliated with the Collège de France in France. Their research contributions span multiple fields, including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. The primary subfields of their work are Immunology, Molecular Biology, Genetics, Infectious Diseases, and Epidemiology.

The scientist's work extensively covers several main research topics, such as Immunodeficiency and Autoimmune Disorders, Immune Cell Function and Interaction, Blood Disorders and Treatments, Cytomegalovirus and Herpesvirus Research, Interferon and Immune Responses, Parvovirus B19 Infection Studies, and SARS-CoV-2 and COVID-19 Research.

Frequent collaborators include Bénédicte Neven, Capucine Pïcard, Despina Moshous, Frédéric Rieux-Laucat, and Nizar Mahlaoui.

Alain Fischer has published numerous papers, with several recent works noted for their relevance and citation impact:

  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients, 2020, Science
  • Coronavirus disease 2019 in patients with inborn errors of immunity: An international study, 2020, Journal of Allergy and Clinical Immunology
  • Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients, 2020, The Journal of Allergy and Clinical Immunology In Practice
  • Initial presenting manifestations in 16,486 patients with inborn errors of immunity include infections and noninfectious manifestations, 2021, Journal of Allergy and Clinical Immunology

The scientist regularly publishes in key journals including the Journal of Allergy and Clinical Immunology, Blood, bioRxiv (Cold Spring Harbor Laboratory), Journal of Clinical Immunology, and Nature Communications.

Alain Fischer is also an author of books, including Genetyka medyczna i molekularna published by Polish Scientific Publishers PWN in 2023, and Le coronavirus et ces microbes qu'il nous faut combattre, première édition published by Frontiers Media in 2022.

Recognition received by Alain Fischer includes membership in prestigious organizations such as the National Academy of Sciences (2019), the National Academy of Medicine (2017), and the European Molecular Biology Organization. They were awarded the Presidential Award by the Clinical Immunology Society in 2016, the Japan Prize in 2015 for the proposal of the concept of gene therapy and its clinical applications, the Robert Koch Prize in 2014, and the Grand Prix scientifique de la Fondation NRJ, Institut de France in 2000.

Best Publications

  • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

    S. Hacein-Bey-Abina;C. Von Kalle;C. Von Kalle;M. Schmidt;M. P. McCormack

  • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

    Marina Cavazzana-Calvo;Salima Hacein-Bey;Geneviève De Saint Basile;Fabian Gross

  • Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

    Jérôme Hadjadj;Nader Yatim;Laura Barnabei;Aurélien Corneau

  • A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency

    Salima Hacein-Bey-Abina;Christof Von Kalle;Manfred Schmidt;Françoise Le Deist

  • Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

    Salima Hacein-Bey-Abina;Alexandrine Garrigue;Gary P. Wang;Jean Soulier

  • Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

    Patrick Revy;Taro Muto;Yves Levy;Frédéric Geissmann

  • Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity

    F. Rieux-Laucat;F. Le Deist;C. Hivroz;I. A. G. Roberts

  • Hematopoietic Stem Cell Gene Therapy with a Lentiviral Vector in X-Linked Adrenoleukodystrophy

    Nathalie Cartier;Salima Hacein-Bey-Abina;Cynthia C. Bartholomae;Gabor Veres

  • Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

    Marina Cavazzana-Calvo;Emmanuel Payen;Olivier Negre;Gary Wang

  • Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages.

    Jean-François Emile;Oussama Abla;Sylvie Fraitag;Annacarin Horne

  • Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis

    Susan E. Stepp;Rémi Dufourcq-Lagelouse;Françoise Le Deist;Françoise Le Deist;Sadhna Bhawan

  • Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy

    Salima Hacein-Bey-Abina;Françoise Le Deist;Frédérique Carlier;Cécile Bouneaud

  • Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome.

    Ménasché G;Pastural E;Feldmann J;Certain S

  • INTERFERON-GAMMA-RECEPTOR DEFICIENCY IN AN INFANT WITH FATAL BACILLE CALMETTE-GUERIN INFECTION

    Emmanuelle Jouanguy;Frédéric Altare;Salma Lamhamedi;Patrick Revy

  • Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

    Jérôme Feldmann;Isabelle Callebaut;Graça Raposo;Stéphanie Certain

  • Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency

    Despina Moshous;Isabelle Callebaut;Régina de Chasseval;Barbara Corneo

  • Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

    James P. Disanto;Werner Muller;Delphine Guy-Grand;Alain Fischer

  • Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency

    Frédéric Altare;Anne Durandy;David Lammas;Jean-François Emile

  • CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

    J. P. Disanto;J. Y. Bonnefoy;J. F. Gauchat;A. Fischer

  • X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.

    Rainer Döffinger;Asma Smahi;Christine Bessia;Frédéric Geissmann

Frequent Co-Authors

Capucine Picard
Capucine Picard Université Paris Cité
Marina Cavazzana-Calvo
Marina Cavazzana-Calvo Necker-Enfants Malades Hospital
Stéphane Blanche
Stéphane Blanche Université Paris Cité
Bénédicte Neven
Bénédicte Neven Université Paris Cité
Despina Moshous
Despina Moshous Necker-Enfants Malades Hospital
Françoise Le Deist
Françoise Le Deist University of Montreal
Geneviève de Saint Basile
Geneviève de Saint Basile Necker-Enfants Malades Hospital
Jean-Laurent Casanova
Jean-Laurent Casanova The University of Texas Southwestern Medical Center
Frédéric Rieux-Laucat
Frédéric Rieux-Laucat Université Paris Cité

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