World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
38
Citations
4717
World Ranking
8626
National Ranking
3666

Overview

Jason M. Uslaner is affiliated with MSD in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine, with a focus on molecular and cellular mechanisms underlying neurological functions and diseases.

The main topical areas of their work include:

  • Neuroscience and Neuropharmacology Research
  • Receptor Mechanisms and Signaling
  • Phosphodiesterase function and regulation
  • Cholinesterase and Neurodegenerative Diseases
  • Nicotinic Acetylcholine Receptors Study
  • Pain Mechanisms and Treatments
  • Lysosomal Storage Disorders Research

The subfields of study related to their publications highlight a concentration on:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Physiology
  • Pharmacology
  • Neurology

Jason M. Uslaner has contributed to multiple peer-reviewed journals, notably including:

  • Journal of Pharmacology and Experimental Therapeutics
  • ACS Medicinal Chemistry Letters
  • Journal of Medicinal Chemistry
  • Neurobiology of Disease
  • Alzheimer's & Dementia

Some of their recent papers are:

  • MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy (2020), published in Journal of Pharmacology and Experimental Therapeutics
  • Discovery of [11C]MK-6884: A Positron Emission Tomography (PET) Imaging Agent for the Study of M4 Muscarinic Receptor Positive Allosteric Modulators (PAMs) in Neurodegenerative Diseases (2020), published in Journal of Medicinal Chemistry
  • Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia (2023), published in Journal of Medicinal Chemistry
  • scRNA-seq generates a molecular map of emerging cell subtypes after sciatic nerve injury in rats (2022), published in Communications Biology
  • The PET tracer [11C]MK-6884 quantifies M4 muscarinic receptor in rhesus monkeys and patients with Alzheimer's disease (2022), published in Science Translational Medicine

Frequent co-authors in Jason M. Uslaner's work include:

  • Sean M. Smith
  • Eric D. Hostetler
  • Liza Gantert
  • Joshua D. Vardigan
  • Kerry Riffel

Best Publications

  • Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.

    Jason M. Uslaner;Sophie Parmentier-Batteur;Rosemarie B. Flick;Nathaniel O. Surles

  • The attribution of incentive salience to a stimulus that signals an intravenous injection of cocaine

    Jason M. Uslaner;Martin J. Acerbo;Samantha A. Jones;Terry E. Robinson

  • Methamphetamine-induced structural plasticity in the dorsal striatum.

    Jakub P. Jedynak;Jason M. Uslaner;José A. Esteban;Terry E. Robinson

  • The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents.

    P.H. Hutson;E.N. Finger;B.C. Magliaro;S.M. Smith

  • Subthalamic nucleus lesions increase impulsive action and decrease impulsive choice - mediation by enhanced incentive motivation?

    Jason M. Uslaner;Terry E. Robinson

  • Amphetamine and cocaine induce different patterns of c-fos mRNA expression in the striatum and subthalamic nucleus depending on environmental context

    Jason Uslaner;Aldo Badiani;Camille S. Norton;Heidi E. W. Day

  • Environmental novelty differentially affects c-fos mRNA expression induced by amphetamine or cocaine in subregions of the bed nucleus of the stria terminalis and amygdala

    Heidi E. W. Day;Aldo Badiani;Aldo Badiani;Jason M. Uslaner;Matthew M. Oates

  • Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens.

    Jason Uslaner;Aldo Badiani;Heidi E.W Day;Stanley J Watson

  • Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure

    Christopher J. Winrow;Keith Q. Tanis;Duane R. Reiss;Alison M. Rigby

  • Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition

    Jason M. Uslaner;Spencer J. Tye;Donnie M. Eddins;Xiaohai Wang

  • Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.

    Sophie Parmentier-Batteur;Peter H. Hutson;Karsten Menzel;Jason M. Uslaner

  • The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

    Anthony L Gotter;Christopher J Winrow;Joseph Brunner;Susan L Garson

  • MK-801 produces a deficit in sucrose preference that is reversed by clozapine, D-serine, and the metabotropic glutamate 5 receptor positive allosteric modulator CDPPB: relevance to negative symptoms associated with schizophrenia?

    Joshua D. Vardigan;Sarah L. Huszar;Caitlyn H. McNaughton;Peter H. Hutson

  • Association of Depressive Symptoms During Abstinence With the Subjective High Produced by Cocaine

    Jason Uslaner;Ari Kalechstein;Todd Richter;Walter Ling

  • The Therapeutic Potential of D-Amino Acid Oxidase (DAAO) Inhibitors.

    Sean M Smith;Jason M Uslaner;Peter H Hutson

  • The Behavioral and Neurochemical Effects of a Novel d-Amino Acid Oxidase Inhibitor Compound 8 [4H-Thieno [3,2-b]pyrrole-5-carboxylic Acid] and d-Serine

    Sean M. Smith;Jason M. Uslaner;Lihang Yao;Chadwick M. Mullins

  • The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.

    Sean M. Smith;Jason M. Uslaner;Christopher D. Cox;Sarah L. Huszar

  • The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.

    Henry S Lange;Christopher E Cannon;Jason T Drott;Scott D Kuduk

  • Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.

    Sophie Parmentier-Batteur;Julie A. OBrien;Scott Doran;Shannon J. Nguyen

  • Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey

    Joshua D. Vardigan;Christopher E. Cannon;Vanita Puri;Mandy Dancho

  • Risperidone pre-treatment reduces the euphoric effects of experimentally administered cocaine

    Thomas F Newton;Walter Ling;Ari D Kalechstein;Jason Uslaner

Frequent Co-Authors

John J. Renger
John J. Renger MSD (United States)
Terry E. Robinson
Terry E. Robinson University of Michigan–Ann Arbor
Huda Akil
Huda Akil University of Michigan–Ann Arbor
Aldo Badiani
Aldo Badiani Sapienza University of Rome
Stanley J. Watson
Stanley J. Watson University of Michigan–Ann Arbor
Thomas W. Rosahl
Thomas W. Rosahl MSD (United States)
Richard Hargreaves
Richard Hargreaves Harvard Medical School
Darrell A. Henze
Darrell A. Henze MSD (United States)
Jun Lu
Jun Lu Zhejiang University
Nicholas J. Brandon
Nicholas J. Brandon Neumora Therapeutics Inc

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you’re interested in neuroscience, you’ll find many related fields offering flexible online degrees to help expand your career options. For those who want to work in mental health or therapy, online msw programs provide an excellent route into social work and clinical practice. Many of these programs offer virtual coursework and allow students to complete fieldwork requirements locally.

Professionals interested in applied behavioral analysis may consider bcba online masters programs which prepare graduates for board certification and open the door to in-demand roles supporting individuals with developmental or behavioral challenges.

Those seeking a faster transition into patient-facing professions might explore a fast track social work degree online. These accelerated pathways are designed for motivated students eager to start making a difference sooner.

Additionally, a 2-year psychology degree online can provide a strong foundation for research, counseling, or future graduate study—making it a versatile option for neuroscience enthusiasts.

Best Scientists Citing Jason M. Uslaner

Trending Scientists