P. Jeffrey Conn mostly deals with Metabotropic glutamate receptor, Neuroscience, Metabotropic glutamate receptor 5, Allosteric regulation and Pharmacology. His Metabotropic glutamate receptor research is within the category of Glutamate receptor. His Neuroscience research includes themes of Long-term potentiation and Glutamatergic.
He interconnects Binding site, Long-term depression and Metabotropic glutamate receptor 3, Metabotropic receptor in the investigation of issues within Metabotropic glutamate receptor 5. His Allosteric regulation research integrates issues from G protein-coupled receptor, Stereochemistry and Potentiator. His Pharmacology research includes elements of Agonist, Muscarinic agonist, NMDA receptor and Antagonist, Receptor antagonist.
P. Jeffrey Conn mainly investigates Allosteric regulation, Metabotropic glutamate receptor, Neuroscience, Pharmacology and Stereochemistry. His studies in Allosteric regulation integrate themes in fields like Muscarinic acetylcholine receptor and In vivo. His Metabotropic glutamate receptor research is multidisciplinary, incorporating perspectives in Potentiator and Metabotropic receptor.
His work deals with themes such as Agonist, Antagonist and G protein-coupled receptor, which intersect with Pharmacology. In his study, Chemical synthesis is strongly linked to Structure–activity relationship, which falls under the umbrella field of Stereochemistry. His Metabotropic glutamate receptor 5 study which covers Metabotropic glutamate receptor 1 that intersects with Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 4 and Metabotropic glutamate receptor 6.
P. Jeffrey Conn focuses on Allosteric regulation, Neuroscience, Metabotropic glutamate receptor, Receptor and Pharmacology. He is interested in Allosteric modulator, which is a branch of Allosteric regulation. His research integrates issues of Synaptic plasticity, Muscarinic acetylcholine receptor and Metabotropic receptor in his study of Neuroscience.
His Metabotropic glutamate receptor study necessitates a more in-depth grasp of Glutamate receptor. His Receptor research is multidisciplinary, relying on both Cell culture and Central nervous system. P. Jeffrey Conn combines subjects such as Striatum and Neurological dysfunction with his study of Pharmacology.
Neuroscience, Allosteric regulation, Receptor, Glutamate receptor and Metabotropic glutamate receptor are his primary areas of study. His study in Neuroscience is interdisciplinary in nature, drawing from both Synaptic plasticity, Muscarinic acetylcholine receptor and Metabotropic receptor. His work carried out in the field of Metabotropic receptor brings together such families of science as Metabotropic glutamate receptor 5, G protein-coupled receptor and Neurotransmission.
The Allosteric regulation study combines topics in areas such as Pharmacology and Drug discovery. The concepts of his Receptor study are interwoven with issues in Stereochemistry and In vivo. His Metabotropic glutamate receptor study frequently draws connections between related disciplines such as Central nervous system.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Colleen M. Niswender;P. Jeffrey Conn.
Annual Review of Pharmacology and Toxicology (2010)
Metabotropic glutamate receptors in brain function and pathology
Darryle D. Schoepp;P.Jeffrey Conn.
Trends in Pharmacological Sciences (1993)
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
P. Jeffrey Conn;Arthur Christopoulos;Craig W. Lindsley;Craig W. Lindsley.
Nature Reviews Drug Discovery (2009)
Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator
Huixian Wu;Chong Wang;Karen J. Gregory;Karen J. Gregory;Gye Won Han.
Science (2014)
Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.
Hazar Awad;George W. Hubert;Yoland Smith;Allan I. Levey.
The Journal of Neuroscience (2000)
Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.
Guido Mannaioni;Michael J. Marino;Ornella Valenti;Ornella Valenti;Stephen F. Traynelis.
The Journal of Neuroscience (2001)
Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia
P. Jeffrey Conn;Craig W. Lindsley;Craig W. Lindsley;Carrie K. Jones.
Trends in Pharmacological Sciences (2009)
Metabotropic glutamate receptors in the basal ganglia motor circuit
P. Jeffrey Conn;Giuseppe Battaglia;Michael J. Marino;Ferdinando Nicoletti.
Nature Reviews Neuroscience (2005)
A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models
Gene G. Kinney;Julie A. O'Brien;Wei Lemaire;Maryann Burno.
Journal of Pharmacology and Experimental Therapeutics (2005)
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity
Cyrille Sur;Pierre J. Mallorga;Marion Wittmann;Marlene A. Jacobson.
Proceedings of the National Academy of Sciences of the United States of America (2003)
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