D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 89 Citations 27,122 511 World Ranking 1644 National Ranking 941

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Neurotransmitter
  • Gene

P. Jeffrey Conn mostly deals with Metabotropic glutamate receptor, Neuroscience, Metabotropic glutamate receptor 5, Allosteric regulation and Pharmacology. His Metabotropic glutamate receptor research is within the category of Glutamate receptor. His Neuroscience research includes themes of Long-term potentiation and Glutamatergic.

He interconnects Binding site, Long-term depression and Metabotropic glutamate receptor 3, Metabotropic receptor in the investigation of issues within Metabotropic glutamate receptor 5. His Allosteric regulation research integrates issues from G protein-coupled receptor, Stereochemistry and Potentiator. His Pharmacology research includes elements of Agonist, Muscarinic agonist, NMDA receptor and Antagonist, Receptor antagonist.

His most cited work include:

  • Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease (1121 citations)
  • Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders (800 citations)
  • Metabotropic glutamate receptors in brain function and pathology (758 citations)

What are the main themes of his work throughout his whole career to date?

P. Jeffrey Conn mainly investigates Allosteric regulation, Metabotropic glutamate receptor, Neuroscience, Pharmacology and Stereochemistry. His studies in Allosteric regulation integrate themes in fields like Muscarinic acetylcholine receptor and In vivo. His Metabotropic glutamate receptor research is multidisciplinary, incorporating perspectives in Potentiator and Metabotropic receptor.

His work deals with themes such as Agonist, Antagonist and G protein-coupled receptor, which intersect with Pharmacology. In his study, Chemical synthesis is strongly linked to Structure–activity relationship, which falls under the umbrella field of Stereochemistry. His Metabotropic glutamate receptor 5 study which covers Metabotropic glutamate receptor 1 that intersects with Metabotropic glutamate receptor 7, Metabotropic glutamate receptor 4 and Metabotropic glutamate receptor 6.

He most often published in these fields:

  • Allosteric regulation (59.38%)
  • Metabotropic glutamate receptor (40.45%)
  • Neuroscience (33.68%)

What were the highlights of his more recent work (between 2017-2021)?

  • Allosteric regulation (59.38%)
  • Neuroscience (33.68%)
  • Metabotropic glutamate receptor (40.45%)

In recent papers he was focusing on the following fields of study:

P. Jeffrey Conn focuses on Allosteric regulation, Neuroscience, Metabotropic glutamate receptor, Receptor and Pharmacology. He is interested in Allosteric modulator, which is a branch of Allosteric regulation. His research integrates issues of Synaptic plasticity, Muscarinic acetylcholine receptor and Metabotropic receptor in his study of Neuroscience.

His Metabotropic glutamate receptor study necessitates a more in-depth grasp of Glutamate receptor. His Receptor research is multidisciplinary, relying on both Cell culture and Central nervous system. P. Jeffrey Conn combines subjects such as Striatum and Neurological dysfunction with his study of Pharmacology.

Between 2017 and 2021, his most popular works were:

  • Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system. (45 citations)
  • M 1 -positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition (30 citations)
  • The therapeutic potential of metabotropic glutamate receptor modulation for schizophrenia. (24 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • Organic chemistry

Neuroscience, Allosteric regulation, Receptor, Glutamate receptor and Metabotropic glutamate receptor are his primary areas of study. His study in Neuroscience is interdisciplinary in nature, drawing from both Synaptic plasticity, Muscarinic acetylcholine receptor and Metabotropic receptor. His work carried out in the field of Metabotropic receptor brings together such families of science as Metabotropic glutamate receptor 5, G protein-coupled receptor and Neurotransmission.

The Allosteric regulation study combines topics in areas such as Pharmacology and Drug discovery. The concepts of his Receptor study are interwoven with issues in Stereochemistry and In vivo. His Metabotropic glutamate receptor study frequently draws connections between related disciplines such as Central nervous system.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

Colleen M. Niswender;P. Jeffrey Conn.
Annual Review of Pharmacology and Toxicology (2010)

1819 Citations

Metabotropic glutamate receptors in brain function and pathology

Darryle D. Schoepp;P.Jeffrey Conn.
Trends in Pharmacological Sciences (1993)

1030 Citations

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

P. Jeffrey Conn;Arthur Christopoulos;Craig W. Lindsley;Craig W. Lindsley.
Nature Reviews Drug Discovery (2009)

1007 Citations

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

Huixian Wu;Chong Wang;Karen J. Gregory;Karen J. Gregory;Gye Won Han.
Science (2014)

537 Citations

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

Hazar Awad;George W. Hubert;Yoland Smith;Allan I. Levey.
The Journal of Neuroscience (2000)

499 Citations

Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function.

Guido Mannaioni;Michael J. Marino;Ornella Valenti;Ornella Valenti;Stephen F. Traynelis.
The Journal of Neuroscience (2001)

480 Citations

Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia

P. Jeffrey Conn;Craig W. Lindsley;Craig W. Lindsley;Carrie K. Jones.
Trends in Pharmacological Sciences (2009)

392 Citations

Metabotropic glutamate receptors in the basal ganglia motor circuit

P. Jeffrey Conn;Giuseppe Battaglia;Michael J. Marino;Ferdinando Nicoletti.
Nature Reviews Neuroscience (2005)

350 Citations

A Novel Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Has in Vivo Activity and Antipsychotic-Like Effects in Rat Behavioral Models

Gene G. Kinney;Julie A. O'Brien;Wei Lemaire;Maryann Burno.
Journal of Pharmacology and Experimental Therapeutics (2005)

343 Citations

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-d-aspartate receptor activity

Cyrille Sur;Pierre J. Mallorga;Marion Wittmann;Marlene A. Jacobson.
Proceedings of the National Academy of Sciences of the United States of America (2003)

308 Citations

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Best Scientists Citing P. Jeffrey Conn

Ferdinando Nicoletti

Ferdinando Nicoletti

Sapienza University of Rome

Publications: 98

Arthur Christopoulos

Arthur Christopoulos

Monash University

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Jean-Philippe Pin

Jean-Philippe Pin

University of Montpellier

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Patrick M. Sexton

Patrick M. Sexton

Monash University

Publications: 72

Craig W. Lindsley

Craig W. Lindsley

Vanderbilt University

Publications: 71

Andrzej Pilc

Andrzej Pilc

Polish Academy of Sciences

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Yoland Smith

Yoland Smith

Emory University

Publications: 53

John Q. Wang

John Q. Wang

University of Missouri–Kansas City

Publications: 44

Darryle D. Schoepp

Darryle D. Schoepp

Independent Scientist / Consultant, US

Publications: 44

Jürgen Wess

Jürgen Wess

National Institutes of Health

Publications: 35

Denise Manahan-Vaughan

Denise Manahan-Vaughan

Ruhr University Bochum

Publications: 33

Paolo Calabresi

Paolo Calabresi

Catholic University of the Sacred Heart

Publications: 30

Graham L. Collingridge

Graham L. Collingridge

Lunenfeld-Tanenbaum Research Institute

Publications: 28

Colleen M. Niswender

Colleen M. Niswender

Vanderbilt University

Publications: 27

Bryan L. Roth

Bryan L. Roth

University of North Carolina at Chapel Hill

Publications: 27

Mark A. Geyer

Mark A. Geyer

University of California, San Diego

Publications: 27

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