Shigeyuki Chaki

Best Publications

• Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

  Hiroyuki Koike;Michihiko Iijima;Shigeyuki Chaki

  448
  Citations

• MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

  Shigeyuki Chaki;Ryoko Yoshikawa;Shiho Hirota;Toshiharu Shimazaki

  356
  Citations

• Neurochemistry of the Nucleus Accumbens and its Relevance to Depression and Antidepressant Action in Rodents

  Yukihiko Shirayama;Shigeyuki Chaki

  282
  Citations

• Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.

  Kenichi Fukumoto;Hidetoh Toki;Michihiko Iijima;Takashi Hashihayata

  248
  Citations

• Mood disorders: regulation by metabotropic glutamate receptors.

  Andrzej Pilc;Shigeyuki Chaki;Gabriel Nowak;Jeffrey M. Witkin

  217
  Citations

• Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.

  Taketoshi Okubo;Ryoko Yoshikawa;Shigeyuki Chaki;Shigeru Okuyama

  215
  Citations

• The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.

  Kenichi Fukumoto;Michihiko Iijima;Shigeyuki Chaki

  209
  Citations

• D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.

  Jun-ichi Karasawa;Kenji Hashimoto;Shigeyuki Chaki

  203
  Citations

• Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

  Hiroyuki Koike;Shigeyuki Chaki

  199
  Citations

• An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

  Takao Yoshimizu;Toshiharu Shimazaki;Akie Ito;Shigeyuki Chaki

  184
  Citations

• AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

  Jun-ichi Karasawa;Toshiharu Shimazaki;Naoya Kawashima;Shigeyuki Chaki

  180
  Citations

• (R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine

  Chun Yang;Youge Qu;Masahito Abe;Dai Nozawa

  178
  Citations

• Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists

  Shigeyuki Chaki;Takeo Funakoshi;Shiho Hirota-Okuno;Mariko Nishiguchi

  174
  Citations

• Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.

  Atsuro Nakazato;Toshihito Kumagai;Kazunari Sakagami;Ryoko Yoshikawa

  172
  Citations

• Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor

  Shigeyuki Chaki;Shiho Hirota;Takeo Funakoshi;Yoshiko Suzuki

  170
  Citations

• Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039.

  Takao Yoshimizu;Shigeyuki Chaki

  170
  Citations

• Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

  Shigeru Okuyama;Takashi Sakagawa;Shigeyuki Chaki;Yasuko Imagawa

  167
  Citations

• Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

  Hiroyuki Koike;Michihiko Iijima;Shigeyuki Chaki

  162
  Citations

• Involvement of melanocortin-4 receptor in anxiety and depression.

  Shigeyuki Chaki;Shigeru Okuyama

  155
  Citations

• Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

  Shigeyuki Chaki;Atsuro Nakazato;Ludo Kennis;Masato Nakamura

  147
  Citations