World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
65
Citations
11520
World Ranking
3189
National Ranking
86

Best Publications

  • Involvement of AMPA receptor in both the rapid and sustained antidepressant-like effects of ketamine in animal models of depression

    Hiroyuki Koike;Michihiko Iijima;Shigeyuki Chaki

  • MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity.

    Shigeyuki Chaki;Ryoko Yoshikawa;Shiho Hirota;Toshiharu Shimazaki

  • Neurochemistry of the Nucleus Accumbens and its Relevance to Depression and Antidepressant Action in Rodents

    Yukihiko Shirayama;Shigeyuki Chaki

  • Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine.

    Kenichi Fukumoto;Hidetoh Toki;Michihiko Iijima;Takashi Hashihayata

  • Mood disorders: regulation by metabotropic glutamate receptors.

    Andrzej Pilc;Shigeyuki Chaki;Gabriel Nowak;Jeffrey M. Witkin

  • Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.

    Taketoshi Okubo;Ryoko Yoshikawa;Shigeyuki Chaki;Shigeru Okuyama

  • The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN.

    Kenichi Fukumoto;Michihiko Iijima;Shigeyuki Chaki

  • D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.

    Jun-ichi Karasawa;Kenji Hashimoto;Shigeyuki Chaki

  • Requirement of AMPA receptor stimulation for the sustained antidepressant activity of ketamine and LY341495 during the forced swim test in rats

    Hiroyuki Koike;Shigeyuki Chaki

  • An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

    Takao Yoshimizu;Toshiharu Shimazaki;Akie Ito;Shigeyuki Chaki

  • AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

    Jun-ichi Karasawa;Toshiharu Shimazaki;Naoya Kawashima;Shigeyuki Chaki

  • (R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine

    Chun Yang;Youge Qu;Masahito Abe;Dai Nozawa

  • Anxiolytic- and Antidepressant-Like Profile of ATC0065 and ATC0175: Nonpeptidic and Orally Active Melanin-Concentrating Hormone Receptor 1 Antagonists

    Shigeyuki Chaki;Takeo Funakoshi;Shiho Hirota-Okuno;Mariko Nishiguchi

  • Synthesis, SARs, and pharmacological characterization of 2-amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists.

    Atsuro Nakazato;Toshihito Kumagai;Kazunari Sakagami;Ryoko Yoshikawa

  • Anxiolytic-Like and Antidepressant-Like Activities of MCL0129 (1-[(S)-2-(4-Fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a Novel and Potent Nonpeptide Antagonist of the Melanocortin-4 Receptor

    Shigeyuki Chaki;Shiho Hirota;Takeo Funakoshi;Yoshiko Suzuki

  • Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039.

    Takao Yoshimizu;Shigeyuki Chaki

  • Anxiety-like behavior in mice lacking the angiotensin II type-2 receptor

    Shigeru Okuyama;Takashi Sakagawa;Shigeyuki Chaki;Yasuko Imagawa

  • Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists

    Hiroyuki Koike;Michihiko Iijima;Shigeyuki Chaki

  • Involvement of melanocortin-4 receptor in anxiety and depression.

    Shigeyuki Chaki;Shigeru Okuyama

  • Anxiolytic- and antidepressant-like profile of a new CRF1 receptor antagonist, R278995/CRA0450.

    Shigeyuki Chaki;Atsuro Nakazato;Ludo Kennis;Masato Nakamura

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