What is he best known for?
The fields of study he is best known for:
- Internal medicine
- Gene
- Enzyme
Pathology, Neuroscience, Alzheimer's disease, Amyloid and Genetically modified mouse are his primary areas of study.
His Pathology study integrates concerns from other disciplines, such as Hippocampus and Nervous system.
The study incorporates disciplines such as Phosphatase and Tauopathy in addition to Neuroscience.
His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Dementia and Degenerative disease.
Makoto Higuchi works mostly in the field of Amyloid, limiting it down to topics relating to Amyloid beta and, in certain cases, Amyloidosis.
The concepts of his Internal medicine study are interwoven with issues in Endocrinology and Neprilysin.
His most cited work include:
- Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model (1151 citations)
- Initiation and synergistic fibrillization of tau and alpha-synuclein. (652 citations)
- Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls (530 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Pathology, Neuroscience, Internal medicine, Positron emission tomography and In vivo.
His research combines Genetically modified mouse and Pathology.
His studies deal with areas such as Neuroinflammation, Tau protein and Neurodegeneration, Tauopathy as well as Neuroscience.
The various areas that Makoto Higuchi examines in his Tauopathy study include Atrophy and Cell biology.
His work in Internal medicine covers topics such as Endocrinology which are related to areas like Neprilysin.
His research investigates the connection between In vivo and topics such as Pharmacology that intersect with problems in Radioligand and Striatum.
He most often published in these fields:
- Pathology (30.29%)
- Neuroscience (26.89%)
- Internal medicine (18.80%)
What were the highlights of his more recent work (between 2018-2021)?
- Positron emission tomography (17.49%)
- Neuroscience (26.89%)
- Tauopathy (11.49%)
In recent papers he was focusing on the following fields of study:
His main research concerns Positron emission tomography, Neuroscience, Tauopathy, Pathology and Neuroinflammation.
His research in Positron emission tomography intersects with topics in Phosphodiesterase, Striatum, Pharmacology and Radioligand.
Makoto Higuchi has researched Neuroscience in several fields, including Receptor and In vivo.
His biological study spans a wide range of topics, including Healthy volunteers, Brain aging, Atrophy and Amyloid.
His Pathology research is multidisciplinary, incorporating perspectives in White matter and Traumatic brain injury.
The various areas that Makoto Higuchi examines in his Neuroinflammation study include Amino acid, Low-protein diet, Endocrinology and Microglia.
Between 2018 and 2021, his most popular works were:
- Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation (34 citations)
- Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. (18 citations)
- Visualization of AMPA Receptors in Living Human Brain With Positron Emission Tomography (16 citations)
In his most recent research, the most cited papers focused on:
- Internal medicine
- Gene
- Enzyme
His primary areas of study are Neuroscience, Positron emission tomography, Tauopathy, Pathology and Receptor.
His research integrates issues of Translocator protein, Microglia, Disease and Anxiogenic in his study of Neuroscience.
His research in the fields of Binding potential overlaps with other disciplines such as Position.
His Tauopathy study results in a more complete grasp of Neurodegeneration.
Makoto Higuchi focuses mostly in the field of Neurodegeneration, narrowing it down to topics relating to Amyloid precursor protein and, in certain cases, Senile plaques, Tau protein, Cell biology and Gene knockin.
His Pathology study combines topics in areas such as White matter and Precuneus.
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