Makoto Higuchi

Overview

Best Publications

• Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

  Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  2436
  Citations

• Initiation and synergistic fibrillization of tau and alpha-synuclein.

  Benoit I. Giasson;Mark S. Forman;Mark S. Forman;Makoto Higuchi;Makoto Higuchi;Lawrence I. Golbe;Lawrence I. Golbe

  1220
  Citations

• Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

  Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  849
  Citations

• Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

  Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman

  840
  Citations

• Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

  Takashi Saito;Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki

  475
  Citations

• 19F and 1H MRI detection of amyloid beta plaques in vivo.

  Makoto Higuchi;Nobuhisa Iwata;Yukio Matsuba;Kumi Sato

  474
  Citations

• Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.

  Yuji Nagai;Naohisa Miyakawa;Hiroyuki Takuwa;Yukiko Hori

  413
  Citations

• Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

  Jun Maeda;Bin Ji;Toshiaki Irie;Takami Tomiyama

  410
  Citations

• Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

  Fumihiko Yasuno;Fumihiko Yasuno;Miho Ota;Miho Ota;Jun Kosaka;Hiroshi Ito

  303
  Citations

• Metabolism of amyloid-β peptide and Alzheimer's disease

  Nobuhisa Iwata;Makoto Higuchi;Takaomi C. Saido

  302
  Citations

• Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

  Nobuyuki Yamasaki;Motoko Maekawa;Katsunori Kobayashi;Yasushi Kajii

  300
  Citations

• Glucose Hypometabolism and Neuropathological Correlates in Brains of Dementia with Lewy Bodies

  Makoto Higuchi;Manabu Tashiro;Hiroyuki Arai;Nobuyuki Okamura

  285
  Citations

• Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

  Akira Sobue;Okiru Komine;Yuichiro Hara;Yuichiro Hara;Fumito Endo

  254
  Citations

• Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function *

  Shu Ming Huang;Akihiro Mouri;Hideko Kokubo;Hideko Kokubo;Ryuichi Nakajima

  249
  Citations

• High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

  Kenji Tagai;Kenji Tagai;Maiko Ono;Manabu Kubota;Manabu Kubota;Soichiro Kitamura;Soichiro Kitamura

  249
  Citations

• Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains EVIDENCE FROM CALPASTATIN MUTANT MICE

  Jiro Takano;Masanori Tomioka;Satoshi Tsubuki;Makoto Higuchi

  247
  Citations

• P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

  Hiroki Takeuchi;Michiyo Iba;Haruhisa Inoue;Makoto Higuchi

  246
  Citations

• Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.

  Bin Ji;Jun Maeda;Makoto Sawada;Maiko Ono

  245
  Citations

• Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

  Maiko Ono;Maiko Ono;Naruhiko Sahara;Katsushi Kumata;Bin Ji

  228
  Citations

• Pharmacokinetics and brain uptake of lactoferrin in rats.

  Bin Ji;Jun Maeda;Makoto Higuchi;Kaori Inoue

  226
  Citations

• Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

  Keizo Takao;Katsunori Kobayashi;Hideo Hagihara;Koji Ohira

  218
  Citations

• Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy

  Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama;Takeshi Ishihara

  218
  Citations

• Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.

  Hiroyuki Arai;Yu ichi Morikawa;Makoto Higuchi;Toshifumi Matsui

  213
  Citations

• Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

  Takeshi Ishihara;Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama

  207
  Citations