2023 - Research.com Neuroscience in Japan Leader Award
Pathology, Neuroscience, Alzheimer's disease, Amyloid and Genetically modified mouse are his primary areas of study. His Pathology study integrates concerns from other disciplines, such as Hippocampus and Nervous system. The study incorporates disciplines such as Phosphatase and Tauopathy in addition to Neuroscience.
His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Dementia and Degenerative disease. Makoto Higuchi works mostly in the field of Amyloid, limiting it down to topics relating to Amyloid beta and, in certain cases, Amyloidosis. The concepts of his Internal medicine study are interwoven with issues in Endocrinology and Neprilysin.
His scientific interests lie mostly in Pathology, Neuroscience, Internal medicine, Positron emission tomography and In vivo. His research combines Genetically modified mouse and Pathology. His studies deal with areas such as Neuroinflammation, Tau protein and Neurodegeneration, Tauopathy as well as Neuroscience.
The various areas that Makoto Higuchi examines in his Tauopathy study include Atrophy and Cell biology. His work in Internal medicine covers topics such as Endocrinology which are related to areas like Neprilysin. His research investigates the connection between In vivo and topics such as Pharmacology that intersect with problems in Radioligand and Striatum.
His main research concerns Positron emission tomography, Neuroscience, Tauopathy, Pathology and Neuroinflammation. His research in Positron emission tomography intersects with topics in Phosphodiesterase, Striatum, Pharmacology and Radioligand. Makoto Higuchi has researched Neuroscience in several fields, including Receptor and In vivo.
His biological study spans a wide range of topics, including Healthy volunteers, Brain aging, Atrophy and Amyloid. His Pathology research is multidisciplinary, incorporating perspectives in White matter and Traumatic brain injury. The various areas that Makoto Higuchi examines in his Neuroinflammation study include Amino acid, Low-protein diet, Endocrinology and Microglia.
His primary areas of study are Neuroscience, Positron emission tomography, Tauopathy, Pathology and Receptor. His research integrates issues of Translocator protein, Microglia, Disease and Anxiogenic in his study of Neuroscience. His research in the fields of Binding potential overlaps with other disciplines such as Position.
His Tauopathy study results in a more complete grasp of Neurodegeneration. Makoto Higuchi focuses mostly in the field of Neurodegeneration, narrowing it down to topics relating to Amyloid precursor protein and, in certain cases, Senile plaques, Tau protein, Cell biology and Gene knockin. His Pathology study combines topics in areas such as White matter and Precuneus.
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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang.
Initiation and synergistic fibrillization of tau and alpha-synuclein.
Benoit I. Giasson;Mark S. Forman;Mark S. Forman;Makoto Higuchi;Makoto Higuchi;Lawrence I. Golbe;Lawrence I. Golbe.
Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'
Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman.
Neurobiology of Aging (1998)
Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls
Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh.
19F and 1H MRI detection of amyloid beta plaques in vivo.
Makoto Higuchi;Nobuhisa Iwata;Yukio Matsuba;Kumi Sato.
Nature Neuroscience (2005)
Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.
Takashi Saito;Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki.
Nature Medicine (2005)
Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography
Jun Maeda;Bin Ji;Toshiaki Irie;Takami Tomiyama.
The Journal of Neuroscience (2007)
Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106
Fumihiko Yasuno;Fumihiko Yasuno;Miho Ota;Miho Ota;Jun Kosaka;Hiroshi Ito.
Biological Psychiatry (2008)
Metabolism of amyloid-β peptide and Alzheimer's disease
Nobuhisa Iwata;Makoto Higuchi;Takaomi C. Saido.
Pharmacology & Therapeutics (2005)
Glucose Hypometabolism and Neuropathological Correlates in Brains of Dementia with Lewy Bodies
Makoto Higuchi;Manabu Tashiro;Hiroyuki Arai;Nobuyuki Okamura.
Experimental Neurology (2000)
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