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Makoto Higuchi

D-Index & Metrics

Discipline name D-Index World Ranking Current World Ranking National Ranking Current National Ranking Publications Citations
Neuroscience 76 1905 1738 40 38 444 22867

Makoto Higuchi publications per year

The chart shows the history of publications by Makoto Higuchi between 1991 and 2025, highlighting the no. of papers published in each year and offering an overview of the publication velocity of this scholar. Makoto Higuchi published across 35 years, from 1991 to 2025, averaging 16 papers a year. Output peaked at 54 publications in 2021. 62 of the 559 publications appeared in the last two years.

No. of publications
10 20 30 40 50
Bar chart. Horizontal axis: year, 1991 to 2025. Vertical axis: number of publications, 0 to 54. Peak 54 publications in 2021. 1991: 1 publication 1992: 0 publications 1993: 0 publications 1994: 2 publications 1995: 0 publications 1996: 5 publications 1997: 6 publications 1998: 6 publications 1999: 6 publications 2000: 8 publications 2001: 6 publications 2002: 7 publications 2003: 3 publications 2004: 12 publications 2005: 15 publications 2006: 15 publications 2007: 18 publications 2008: 12 publications 2009: 15 publications 2010: 14 publications 2011: 11 publications 2012: 17 publications 2013: 17 publications 2014: 24 publications 2015: 25 publications 2016: 26 publications 2017: 34 publications 2018: 22 publications 2019: 21 publications 2020: 25 publications 2021: 54 publications 2022: 30 publications 2023: 40 publications 2024: 28 publications 2025: 34 publications
1991 2025

559 publications in total across all disciplines

View publications per year as a table
Makoto Higuchi: publications per year, 1991 to 2025
Year Publications
1991 1
1992 0
1993 0
1994 2
1995 0
1996 5
1997 6
1998 6
1999 6
2000 8
2001 6
2002 7
2003 3
2004 12
2005 15
2006 15
2007 18
2008 12
2009 15
2010 14
2011 11
2012 17
2013 17
2014 24
2015 25
2016 26
2017 34
2018 22
2019 21
2020 25
2021 54
2022 30
2023 40
2024 28
2025 34
Total 559
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Makoto Higuchi publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where Makoto Higuchi sits on this spectrum.

No. of scientists
100 200 300 400 500
Bar chart with 86 bars. Horizontal axis: publications, 38–47 to 887+. Vertical axis: number of scientists, 0 to 539. Most scientists, 539, have 98–107 publications. The last bar groups every scientist with 887 publications or more. The highlighted bar, 438–447 publications, is where this scientist sits. 38–47 publications: 18 scientists 48–57 publications: 79 scientists 58–67 publications: 193 scientists 68–77 publications: 323 scientists 78–87 publications: 406 scientists 88–97 publications: 452 scientists 98–107 publications: 539 scientists 108–117 publications: 505 scientists 118–127 publications: 522 scientists 128–137 publications: 469 scientists 138–147 publications: 456 scientists 148–157 publications: 459 scientists 158–167 publications: 397 scientists 168–177 publications: 383 scientists 178–187 publications: 350 scientists 188–197 publications: 302 scientists 198–207 publications: 306 scientists 208–217 publications: 262 scientists 218–227 publications: 242 scientists 228–237 publications: 220 scientists 238–247 publications: 203 scientists 248–257 publications: 174 scientists 258–267 publications: 176 scientists 268–277 publications: 175 scientists 278–287 publications: 125 scientists 288–297 publications: 116 scientists 298–307 publications: 127 scientists 308–317 publications: 128 scientists 318–327 publications: 99 scientists 328–337 publications: 89 scientists 338–347 publications: 78 scientists 348–357 publications: 96 scientists 358–367 publications: 66 scientists 368–377 publications: 59 scientists 378–387 publications: 65 scientists 388–397 publications: 54 scientists 398–407 publications: 48 scientists 408–417 publications: 49 scientists 418–427 publications: 34 scientists 428–437 publications: 31 scientists 438–447 publications: 30 scientists 448–457 publications: 31 scientists 458–467 publications: 36 scientists 468–477 publications: 40 scientists 478–487 publications: 35 scientists 488–497 publications: 30 scientists 498–507 publications: 23 scientists 508–517 publications: 26 scientists 518–527 publications: 20 scientists 528–537 publications: 23 scientists 538–547 publications: 20 scientists 548–557 publications: 20 scientists 558–567 publications: 17 scientists 568–577 publications: 14 scientists 578–587 publications: 20 scientists 588–597 publications: 20 scientists 598–607 publications: 19 scientists 608–617 publications: 18 scientists 618–627 publications: 17 scientists 628–637 publications: 11 scientists 638–647 publications: 11 scientists 648–657 publications: 11 scientists 658–667 publications: 8 scientists 668–677 publications: 7 scientists 678–687 publications: 11 scientists 688–697 publications: 10 scientists 698–707 publications: 4 scientists 708–717 publications: 6 scientists 718–727 publications: 5 scientists 728–737 publications: 5 scientists 738–747 publications: 9 scientists 748–757 publications: 9 scientists 758–767 publications: 3 scientists 768–777 publications: 7 scientists 778–787 publications: 7 scientists 788–797 publications: 6 scientists 798–807 publications: 2 scientists 808–817 publications: 2 scientists 818–827 publications: 7 scientists 828–837 publications: 0 scientists 838–847 publications: 9 scientists 848–857 publications: 3 scientists 858–867 publications: 1 scientist 868–877 publications: 3 scientists 878–886 publications: 6 scientists 887+ publications: 100 scientists
38–47 publications 887+

This scientist: 444 publications — 93rd percentile

93% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 887 publications or more.

View publications distribution as a table
Number of Neuroscience scientists by publication count, Research.com 2026 ranking edition. Based on 9,597 ranked scientists.
Publications Scientists This scientist
38–47 18
48–57 79
58–67 193
68–77 323
78–87 406
88–97 452
98–107 539
108–117 505
118–127 522
128–137 469
138–147 456
148–157 459
158–167 397
168–177 383
178–187 350
188–197 302
198–207 306
208–217 262
218–227 242
228–237 220
238–247 203
248–257 174
258–267 176
268–277 175
278–287 125
288–297 116
298–307 127
308–317 128
318–327 99
328–337 89
338–347 78
348–357 96
358–367 66
368–377 59
378–387 65
388–397 54
398–407 48
408–417 49
418–427 34
428–437 31
438–447 30 444
448–457 31
458–467 36
468–477 40
478–487 35
488–497 30
498–507 23
508–517 26
518–527 20
528–537 23
538–547 20
548–557 20
558–567 17
568–577 14
578–587 20
588–597 20
598–607 19
608–617 18
618–627 17
628–637 11
638–647 11
648–657 11
658–667 8
668–677 7
678–687 11
688–697 10
698–707 4
708–717 6
718–727 5
728–737 5
738–747 9
748–757 9
758–767 3
768–777 7
778–787 7
788–797 6
798–807 2
808–817 2
818–827 7
828–837 0
838–847 9
848–857 3
858–867 1
868–877 3
878–886 6
887+ 100
Download as CSV

Makoto Higuchi D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where Makoto Higuchi sits on this spectrum.

No. of scientists
100 200 300 400 500
Bar chart with 68 bars. Horizontal axis: D-Index, 30–31 to 163+. Vertical axis: number of scientists, 0 to 512. Most scientists, 512, have 46–47 D-Index. The last bar groups every scientist with 163 D-Index or more. The highlighted bar, 76–77 D-Index, is where this scientist sits. 30–31 D-Index: 42 scientists 32–33 D-Index: 172 scientists 34–35 D-Index: 296 scientists 36–37 D-Index: 435 scientists 38–39 D-Index: 459 scientists 40–41 D-Index: 456 scientists 42–43 D-Index: 467 scientists 44–45 D-Index: 478 scientists 46–47 D-Index: 512 scientists 48–49 D-Index: 435 scientists 50–51 D-Index: 425 scientists 52–53 D-Index: 418 scientists 54–55 D-Index: 392 scientists 56–57 D-Index: 357 scientists 58–59 D-Index: 334 scientists 60–61 D-Index: 328 scientists 62–63 D-Index: 260 scientists 64–65 D-Index: 278 scientists 66–67 D-Index: 239 scientists 68–69 D-Index: 250 scientists 70–71 D-Index: 210 scientists 72–73 D-Index: 200 scientists 74–75 D-Index: 189 scientists 76–77 D-Index: 170 scientists 78–79 D-Index: 146 scientists 80–81 D-Index: 113 scientists 82–83 D-Index: 126 scientists 84–85 D-Index: 100 scientists 86–87 D-Index: 84 scientists 88–89 D-Index: 99 scientists 90–91 D-Index: 84 scientists 92–93 D-Index: 85 scientists 94–95 D-Index: 72 scientists 96–97 D-Index: 76 scientists 98–99 D-Index: 45 scientists 100–101 D-Index: 49 scientists 102–103 D-Index: 43 scientists 104–105 D-Index: 32 scientists 106–107 D-Index: 45 scientists 108–109 D-Index: 50 scientists 110–111 D-Index: 32 scientists 112–113 D-Index: 39 scientists 114–115 D-Index: 32 scientists 116–117 D-Index: 29 scientists 118–119 D-Index: 27 scientists 120–121 D-Index: 19 scientists 122–123 D-Index: 23 scientists 124–125 D-Index: 27 scientists 126–127 D-Index: 16 scientists 128–129 D-Index: 24 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 21 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 14 scientists 138–139 D-Index: 15 scientists 140–141 D-Index: 10 scientists 142–143 D-Index: 10 scientists 144–145 D-Index: 13 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 8 scientists 150–151 D-Index: 6 scientists 152–153 D-Index: 6 scientists 154–155 D-Index: 7 scientists 156–157 D-Index: 7 scientists 158–159 D-Index: 10 scientists 160–161 D-Index: 4 scientists 162 D-Index: 8 scientists 163+ D-Index: 100 scientists
30–31 D-Index 163+

This scientist: 76 D-Index — 80th percentile

80% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 163 D-Index or more.

View D-Index distribution as a table
Number of Neuroscience scientists by D-index, Research.com 2026 ranking edition. Based on 9,597 ranked scientists.
D-Index Scientists This scientist
30–31 42
32–33 172
34–35 296
36–37 435
38–39 459
40–41 456
42–43 467
44–45 478
46–47 512
48–49 435
50–51 425
52–53 418
54–55 392
56–57 357
58–59 334
60–61 328
62–63 260
64–65 278
66–67 239
68–69 250
70–71 210
72–73 200
74–75 189
76–77 170 76
78–79 146
80–81 113
82–83 126
84–85 100
86–87 84
88–89 99
90–91 84
92–93 85
94–95 72
96–97 76
98–99 45
100–101 49
102–103 43
104–105 32
106–107 45
108–109 50
110–111 32
112–113 39
114–115 32
116–117 29
118–119 27
120–121 19
122–123 23
124–125 27
126–127 16
128–129 24
130–131 13
132–133 21
134–135 17
136–137 14
138–139 15
140–141 10
142–143 10
144–145 13
146–147 9
148–149 8
150–151 6
152–153 6
154–155 7
156–157 7
158–159 10
160–161 4
162 8
163+ 100
Download as CSV

Overview

Makoto Higuchi is affiliated with the National Institutes for Quantum and Radiological Science and Technology in Japan. Their research primarily spans the fields of Medicine and Neuroscience, with a focus on subfields including Physiology, Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging, Neurology, and Cellular and Molecular Neuroscience.

Higuchi's work covers a range of topics related to brain sciences and neurodegenerative diseases. The main topics include:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neuropharmacology Research
  • Functional Brain Connectivity Studies
  • Dementia and Cognitive Impairment Research
  • Medical Imaging Techniques and Applications
  • Parkinson's Disease Mechanisms and Treatments
  • Advanced Neuroimaging Techniques and Applications

The scientist has contributed to numerous publications, with frequent appearances in various peer-reviewed venues. The most common publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Journal of Cerebral Blood Flow & Metabolism
  • Scientific Reports

Among recent papers authored or coauthored by Higuchi are:

  • "Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys," 2020, Nature Neuroscience
  • "Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease," 2021, Acta Neuropathologica Communications
  • "High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer's and Non-Alzheimer's Disease Tauopathies," 2020, Neuron
  • "Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607," 2021, Acta Neuropathologica
  • "Selective Disruption of Inhibitory Synapses Leading to Neuronal Hyperexcitability at an Early Stage of Tau Pathogenesis in a Mouse Model," 2020, Journal of Neuroscience

Frequent coauthors in Higuchi's research include:

  • Ming-Rong Zhang
  • Keisuke Takahata
  • Kenji Tagai
  • Yuhei Takado
  • Chie Seki

Best Publications

  • Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

    Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  • Initiation and synergistic fibrillization of tau and alpha-synuclein.

    Benoit I. Giasson;Mark S. Forman;Mark S. Forman;Makoto Higuchi;Makoto Higuchi;Lawrence I. Golbe;Lawrence I. Golbe

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

    Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman

  • Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

    Takashi Saito;Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki

  • 19F and 1H MRI detection of amyloid beta plaques in vivo.

    Makoto Higuchi;Nobuhisa Iwata;Yukio Matsuba;Kumi Sato

  • Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.

    Yuji Nagai;Naohisa Miyakawa;Hiroyuki Takuwa;Yukiko Hori

  • Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

    Jun Maeda;Bin Ji;Toshiaki Irie;Takami Tomiyama

  • Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

    Fumihiko Yasuno;Fumihiko Yasuno;Miho Ota;Miho Ota;Jun Kosaka;Hiroshi Ito

  • Metabolism of amyloid-β peptide and Alzheimer's disease

    Nobuhisa Iwata;Makoto Higuchi;Takaomi C. Saido

  • Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

    Nobuyuki Yamasaki;Motoko Maekawa;Katsunori Kobayashi;Yasushi Kajii

  • Glucose Hypometabolism and Neuropathological Correlates in Brains of Dementia with Lewy Bodies

    Makoto Higuchi;Manabu Tashiro;Hiroyuki Arai;Nobuyuki Okamura

  • Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

    Akira Sobue;Okiru Komine;Yuichiro Hara;Yuichiro Hara;Fumito Endo

  • Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function *

    Shu Ming Huang;Akihiro Mouri;Hideko Kokubo;Hideko Kokubo;Ryuichi Nakajima

  • High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

    Kenji Tagai;Kenji Tagai;Maiko Ono;Manabu Kubota;Manabu Kubota;Soichiro Kitamura;Soichiro Kitamura

  • Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains EVIDENCE FROM CALPASTATIN MUTANT MICE

    Jiro Takano;Masanori Tomioka;Satoshi Tsubuki;Makoto Higuchi

  • P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

    Hiroki Takeuchi;Michiyo Iba;Haruhisa Inoue;Makoto Higuchi

  • Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.

    Bin Ji;Jun Maeda;Makoto Sawada;Maiko Ono

  • Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

    Maiko Ono;Maiko Ono;Naruhiko Sahara;Katsushi Kumata;Bin Ji

  • Pharmacokinetics and brain uptake of lactoferrin in rats.

    Bin Ji;Jun Maeda;Makoto Higuchi;Kaori Inoue

  • Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

    Keizo Takao;Katsunori Kobayashi;Hideo Hagihara;Koji Ohira

  • Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy

    Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama;Takeshi Ishihara

  • Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.

    Hiroyuki Arai;Yu ichi Morikawa;Makoto Higuchi;Toshifumi Matsui

  • Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

    Takeshi Ishihara;Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama

Frequent Co-Authors

Tetsuya Suhara
Tetsuya Suhara National Institutes for Quantum and Radiological Science and Technology
Hitoshi Shinotoh
Hitoshi Shinotoh National Institutes for Quantum and Radiological Science and Technology
Hiroyuki Arai
Hiroyuki Arai University of Tokyo
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania
Hiroshi Ito
Hiroshi Ito Fukushima Medical University
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Nobuyuki Okamura
Nobuyuki Okamura Tohoku Medical and Pharmaceutical University
Takaomi C. Saido
Takaomi C. Saido RIKEN Center for Brain Science
Nobuhisa Iwata
Nobuhisa Iwata Nagasaki University
Masatoshi Itoh
Masatoshi Itoh Tohoku University

External Links

Personal website of Makoto Higuchi

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Best Scientists Citing Makoto Higuchi

John Q. Trojanowski

John Q. Trojanowski

University of Pennsylvania

Publications: 154

Virginia M.-Y. Lee

Virginia M.-Y. Lee

University of Pennsylvania

Publications: 124

Tsuyoshi Miyakawa

Tsuyoshi Miyakawa

Fujita Health University

Publications: 116

Kaj Blennow

Kaj Blennow

University of Gothenburg

Publications: 114

Nobuyuki Okamura

Nobuyuki Okamura

Tohoku Medical and Pharmaceutical University

Publications: 82

Kazuhiko Yanai

Kazuhiko Yanai

Tohoku University

Publications: 81

Keizo Takao

Keizo Takao

University of Toyama

Publications: 64

Dennis W. Dickson

Dennis W. Dickson

Mayo Clinic

Publications: 62

Agneta Nordberg

Agneta Nordberg

Karolinska University Hospital

Publications: 62

Hiroyuki Arai

Hiroyuki Arai

University of Tokyo

Publications: 61

David J. Brooks

David J. Brooks

Newcastle University

Publications: 58

Harald Hampel

Harald Hampel

Eisai (United States)

Publications: 58

Henrik Zetterberg

Henrik Zetterberg

University of Gothenburg

Publications: 58

Victor L. Villemagne

Victor L. Villemagne

University of Pittsburgh

Publications: 50

Manabu Tashiro

Manabu Tashiro

Tohoku University

Publications: 50

Eliezer Masliah

Eliezer Masliah

National Institutes of Health

Publications: 47

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