Makoto Higuchi

Makoto Higuchi publication distribution in Neuroscience in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Neuroscience in 2026. The highlighted bar marks where Makoto Higuchi sits on this spectrum.

Makoto Higuchi D-index placement in Neuroscience in 2026

The chart shows the D-index (discipline H-index) distribution of Neuroscience scientists ranked by Research.com in 2026. The highlighted bar marks where Makoto Higuchi sits on this spectrum.

Overview

Best Publications

• Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

  Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  2436
  Citations

• Initiation and synergistic fibrillization of tau and alpha-synuclein.

  Benoit I. Giasson;Mark S. Forman;Mark S. Forman;Makoto Higuchi;Makoto Higuchi;Lawrence I. Golbe;Lawrence I. Golbe

  1220
  Citations

• Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

  Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  849
  Citations

• Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease'

  Peter Davies;Judith Resnick;Burton Resnick;Sid Gilman

  840
  Citations

• Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

  Takashi Saito;Nobuhisa Iwata;Satoshi Tsubuki;Yoshie Takaki

  475
  Citations

• 19F and 1H MRI detection of amyloid beta plaques in vivo.

  Makoto Higuchi;Nobuhisa Iwata;Yukio Matsuba;Kumi Sato

  474
  Citations

• Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.

  Yuji Nagai;Naohisa Miyakawa;Hiroyuki Takuwa;Yukiko Hori

  413
  Citations

• Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography

  Jun Maeda;Bin Ji;Toshiaki Irie;Takami Tomiyama

  410
  Citations

• Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

  Fumihiko Yasuno;Fumihiko Yasuno;Miho Ota;Miho Ota;Jun Kosaka;Hiroshi Ito

  303
  Citations

• Metabolism of amyloid-β peptide and Alzheimer's disease

  Nobuhisa Iwata;Makoto Higuchi;Takaomi C. Saido

  302
  Citations

• Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

  Nobuyuki Yamasaki;Motoko Maekawa;Katsunori Kobayashi;Yasushi Kajii

  300
  Citations

• Glucose Hypometabolism and Neuropathological Correlates in Brains of Dementia with Lewy Bodies

  Makoto Higuchi;Manabu Tashiro;Hiroyuki Arai;Nobuyuki Okamura

  285
  Citations

• Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

  Akira Sobue;Okiru Komine;Yuichiro Hara;Yuichiro Hara;Fumito Endo

  254
  Citations

• Neprilysin-sensitive Synapse-associated Amyloid-β Peptide Oligomers Impair Neuronal Plasticity and Cognitive Function *

  Shu Ming Huang;Akihiro Mouri;Hideko Kokubo;Hideko Kokubo;Ryuichi Nakajima

  249
  Citations

• High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

  Kenji Tagai;Kenji Tagai;Maiko Ono;Manabu Kubota;Manabu Kubota;Soichiro Kitamura;Soichiro Kitamura

  249
  Citations

• Calpain Mediates Excitotoxic DNA Fragmentation via Mitochondrial Pathways in Adult Brains EVIDENCE FROM CALPASTATIN MUTANT MICE

  Jiro Takano;Masanori Tomioka;Satoshi Tsubuki;Makoto Higuchi

  247
  Citations

• P301S Mutant Human Tau Transgenic Mice Manifest Early Symptoms of Human Tauopathies with Dementia and Altered Sensorimotor Gating

  Hiroki Takeuchi;Michiyo Iba;Haruhisa Inoue;Makoto Higuchi

  246
  Citations

• Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.

  Bin Ji;Jun Maeda;Makoto Sawada;Maiko Ono

  245
  Citations

• Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies

  Maiko Ono;Maiko Ono;Naruhiko Sahara;Katsushi Kumata;Bin Ji

  228
  Citations

• Pharmacokinetics and brain uptake of lactoferrin in rats.

  Bin Ji;Jun Maeda;Makoto Higuchi;Kaori Inoue

  226
  Citations

• Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

  Keizo Takao;Katsunori Kobayashi;Hideo Hagihara;Koji Ohira

  218
  Citations

• Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy

  Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama;Takeshi Ishihara

  218
  Citations

• Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathology.

  Hiroyuki Arai;Yu ichi Morikawa;Makoto Higuchi;Toshifumi Matsui

  213
  Citations

• Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice.

  Takeshi Ishihara;Bin Zhang;Makoto Higuchi;Yasumasa Yoshiyama

  207
  Citations