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Neuroscience

D-Index
63
Citations
12801
World Ranking
3411
National Ranking
95

Overview

Nobuyuki Okamura is affiliated with Tohoku Medical and Pharmaceutical University in Japan and has contributed extensively to research in medicine and neuroscience, with a particular focus on neurology, physiology, and cellular and molecular neuroscience. Their work spans several interconnected fields including psychiatry and mental health, as well as radiology, nuclear medicine, and imaging.

Their primary research topics encompass Alzheimer's disease research and treatments, neuroscience and neuropharmacology research, dementia and cognitive impairment research, and neuroinflammation and neurodegeneration mechanisms. Additional areas include Parkinson's disease mechanisms and treatments, cerebrospinal fluid and hydrocephalus, and sleep and wakefulness research.

Okamura has published in a variety of scientific venues, frequently contributing to:

  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Nuclear Medicine and Biology
  • Alzheimer's & Dementia
  • Scientific Reports
  • Journal of Nuclear Medicine

Their recent papers highlight several advances in neuroimaging and neurodegenerative disease studies, including:

  • "Decreased CSF clearance and increased brain amyloid in Alzheimer's disease" (2022), published in Fluids and Barriers of the CNS
  • "18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging" (2020), published in Journal of Nuclear Medicine
  • "APOE ɛ4dose associates with increased brain iron and β-amyloid via blood-brain barrier dysfunction" (2022), published in Journal of Neurology Neurosurgery & Psychiatry
  • "First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis" (2022), published in Journal of Nuclear Medicine
  • "Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum" (2022), published in Journal of Nuclear Medicine

Among frequent co-authors are:

  • Ryuichi Harada
  • Yukitsuka Kudo
  • Shozo Furumoto
  • Kazuhiko Yanai
  • Tadaho Nakamura

The body of work by Nobuyuki Okamura is multidisciplinary, integrating advances in neuroimaging techniques and biochemical markers with studies focused on brain amyloid deposition, blood-brain barrier dysfunction, and the neurobiological underpinnings of neurodegenerative diseases.

Best Publications

  • Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

    Masahiro Maruyama;Hitoshi Shimada;Tetsuya Suhara;Hitoshi Shinotoh

  • 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer’s disease

    Michelle T Fodero-Tavoletti;Nobuyuki Okamura;Shozo Furumoto;Rachel S Mulligan

  • 18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease.

    Ryuichi Harada;Nobuyuki Okamura;Shozo Furumoto;Katsutoshi Furukawa

  • Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

    Kok Pin Ng;Tharick A. Pascoal;Sulantha Mathotaarachchi;Joseph Therriault

  • Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease.

    Nobuyuki Okamura;Shozo Furumoto;Ryuichi Harada;Tetsuro Tago

  • 2-(2-[2-Dimethylaminothiazol-5-yl]Ethenyl)-6- (2-[Fluoro]Ethoxy)Benzoxazole: A Novel PET Agent for In Vivo Detection of Dense Amyloid Plaques in Alzheimer's Disease Patients

    Yukitsuka Kudo;Nobuyuki Okamura;Shozo Furumoto;Manabu Tashiro

  • Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.

    Nobuyuki Okamura;Shozo Furumoto;Michelle T. Fodero-Tavoletti;Rachel S. Mulligan

  • Glucose Hypometabolism and Neuropathological Correlates in Brains of Dementia with Lewy Bodies

    Makoto Higuchi;Manabu Tashiro;Hiroyuki Arai;Nobuyuki Okamura

  • Quinoline and Benzimidazole Derivatives: Candidate Probes for In Vivo Imaging of Tau Pathology in Alzheimer's Disease

    Nobuyuki Okamura;Takahiro Suemoto;Shozo Furumoto;Masako Suzuki

  • Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.

    Mony J. de Leon;Yi Li;Nobuyuki Okamura;Wai H. Tsui

  • The development and validation of tau PET tracers: current status and future directions.

    Nobuyuki Okamura;Ryuichi Harada;Aiko Ishiki;Akio Kikuchi

  • Sleep Patterns and Mortality among Elderly Patients in a Geriatric Hospital

    K. Manabe;T. Matsui;M. Yamaya;T. Sato-Nakagawa

  • In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

    Victor L. Villemagne;Shozo Furumoto;Michelle T. Fodero-Tavoletti;Rachel S. Mulligan

  • Tau PET imaging in Alzheimer's disease.

    Nobuyuki Okamura;Ryuichi Harada;Shozo Furumoto;Hiroyuki Arai

  • Histamine H1 receptors in patients with Alzheimer’s disease assessed by positron emission tomography

    M Higuchi;K Yanai;N Okamura;K Meguro

  • Selective cognitive dysfunction in mice lacking histamine H1 and H2 receptors.

    Hongmei Dai;Kenya Kaneko;Hiroshi Kato;Satoshi Fujii

  • CSF Phosphorylated Tau Protein and Mild Cognitive Impairment: A Prospective Study

    Hiroyuki Arai;Koichi Ishiguro;Hideto Ohno;Michiko Moriyama

  • Correlations of 18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease.

    Ryuichi Harada;Aiko Ishiki;Hideaki Kai;Naomi Sato

  • Functional neuroimaging of cognition impaired by a classical antihistamine, d‐chlorpheniramine

    Nobuyuki Okamura;Kazuhiko Yanai;Makoto Higuchi;Jun Sakai

  • [18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

    Ryuichi Harada;Nobuyuki Okamura;Shozo Furumoto;Katsutoshi Furukawa

  • Combined Analysis of CSF Tau Levels and [123I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer’s Disease

    Nobuyuki Okamura;Hiroyuki Arai;Masahiro Maruyama;Makoto Higuchi

Frequent Co-Authors

Kazuhiko Yanai
Kazuhiko Yanai Tohoku University
Manabu Tashiro
Manabu Tashiro Tohoku University
Makoto Higuchi
Makoto Higuchi National Institutes for Quantum and Radiological Science and Technology
Masatoshi Itoh
Masatoshi Itoh Tohoku University
Agneta Nordberg
Agneta Nordberg Karolinska University Hospital
Matthias Brendel
Matthias Brendel Ludwig-Maximilians-Universität München
Colin L. Masters
Colin L. Masters University of Melbourne
Hiroshi Fukuda
Hiroshi Fukuda Tohoku University
John Drago
John Drago University of Melbourne
Harumasa Takano
Harumasa Takano National Institutes for Quantum and Radiological Science and Technology

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