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Neuroscience

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  • 2025 - Research.com Rising Stars Award

Overview

Matthias Brendel is affiliated with Ludwig-Maximilians-Universität München in Germany, contributing extensively to research in medicine and neuroscience. Their work primarily lies at the intersection of radiology, nuclear medicine, neurology, physiology, psychiatry and mental health, and cognitive neuroscience.

The research topics covered by Matthias Brendel include:

  • Alzheimer's disease research and treatments
  • Medical Imaging Techniques and Applications
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Dementia and Cognitive Impairment Research
  • Functional Brain Connectivity Studies
  • Glioma Diagnosis and Treatment
  • Parkinson's Disease Mechanisms and Treatments

Their publications span various high-impact journals and frequently published venues, such as:

  • Alzheimer s & Dementia
  • Nuklearmedizin - NuclearMedicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Nuclear Medicine

Among recent papers, notable examples include:

  • "White matter aging drives microglial diversity," 2021, published in Neuron
  • "EANM procedure guidelines for brain PET imaging using [18F]FDG, version 3," 2021, European Journal of Nuclear Medicine and Molecular Imaging
  • "Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy," 2020, JAMA Neurology
  • "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases," 2021, Science Translational Medicine
  • "A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models," 2023, Nature Neuroscience

Collaborations have been made with several frequent co-authors, including:

  • Nicolai Franzmeier
  • Peter Bartenstein
  • Johannes Levin
  • Nathalie L. Albert
  • Leonie Beyer

Best Publications

  • Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.

    Samira Parhizkar;Thomas Arzberger;Matthias Brendel;Gernot Kleinberger

  • sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

    Marc Suárez-Calvet;Marc Suárez-Calvet;Gernot Kleinberger;Miguel Ángel Araque Caballero;Matthias Brendel

  • White matter aging drives microglial diversity.

    Shima Safaiyan;Simon Besson-Girard;Tuğberk Kaya;Ludovico Cantuti-Castelvetri;Ludovico Cantuti-Castelvetri

  • The FTD‐like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism

    Gernot Kleinberger;Matthias Brendel;Eva Mracsko;Benedikt Wefers

  • A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

    Unknown

  • Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.

    Xianyuan Xiang;Xianyuan Xiang;Karin Wind;Karin Wind;Thomas Wiedemann;Tanja Blume;Tanja Blume

  • Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy.

    Matthias Brendel;Henryk Barthel;Thilo van Eimeren;Thilo van Eimeren;Ken Marek

  • Four-repeat tauopathies.

    Thomas W. Rösler;Amir Tayaranian Marvian;Matthias Brendel;Niko-Petteri Nykänen

  • Improved longitudinal [(18)F]-AV45 amyloid PET by white matter reference and VOI-based partial volume effect correction.

    Matthias Brendel;Marcus Högenauer;Andreas Delker;Julia Sauerbeck

  • Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

    Matthias Brendel;Federico Probst;Anna Jaworska;Felix Overhoff

  • Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

    Unknown

  • Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals.

    Davina Biel;Matthias Brendel;Anna Rubinski;Katharina Buerger;Katharina Buerger

  • Reduced FDG-PET brain metabolism and executive function predict clinical progression in elderly healthy subjects

    Michael Ewers;Matthias Brendel;Angela Rizk-Jackson;Axel Rominger

  • Tau deposition patterns are associated with functional connectivity in primary tauopathies

    Unknown

  • Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

    Unknown

  • Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

    Michael Ewers;Michael Ewers;Gloria Biechele;Marc Suárez-Calvet;Christian Sacher

  • Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

    Julia K Götzl;Matthias Brendel;Georg Werner;Samira Parhizkar

  • TSPO PET for glioma imaging using the novel ligand 18F-GE-180: first results in patients with glioblastoma.

    Nathalie L. Albert;Nathalie L. Albert;M. Unterrainer;D. F. Fleischmann;D. F. Fleischmann;S. Lindner

  • Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

    Unknown

  • Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases.

    Sonja Daerr;Matthias Brendel;Christian Zach;Erik Mille

  • Early static (18)F-FET-PET scans have a higher accuracy for glioma grading than the standard 20-40 min scans.

    Nathalie L. Albert;Isabel Winkelmann;Bogdana Suchorska;Vera Wenter

  • Depressive symptoms accelerate cognitive decline in amyloid-positive MCI patients

    Matthias Brendel;Oliver Pogarell;Guoming Xiong;Andreas Delker

  • Longitudinal Assessment of Cerebral β-Amyloid Deposition in Mice Overexpressing Swedish Mutant β-Amyloid Precursor Protein Using 18F-Florbetaben PET

    Axel Rominger;Matthias Brendel;Steffen Burgold;Kevin Keppler

  • Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

    Matthias Brendel;Gernot Kleinberger;Federico Probst;Anna Jaworska;Anna Jaworska

  • Cortical [18 F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes.

    Carla Palleis;Carla Palleis;Matthias Brendel;Anika Finze;Endy Weidinger;Endy Weidinger

Frequent Co-Authors

Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Robert Perneczky
Robert Perneczky Ludwig-Maximilians-Universität München
Paul Cumming
Paul Cumming Queensland University of Technology
Henryk Barthel
Henryk Barthel Leipzig University
Katharina Buerger
Katharina Buerger Ludwig-Maximilians-Universität München
Michael Ewers
Michael Ewers Ludwig-Maximilians-Universität München
Oliver Pogarell
Oliver Pogarell Ludwig-Maximilians-Universität München
Joseph Classen
Joseph Classen Leipzig University
Martin Dichgans
Martin Dichgans Ludwig-Maximilians-Universität München
Marianne Dieterich
Marianne Dieterich Ludwig-Maximilians-Universität München

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