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Biology and Biochemistry

D-Index
72
Citations
31363
World Ranking
6131
National Ranking
2875

Overview

Susan M. Freier is affiliated with Ionis Pharmaceuticals in the United States. Their research focuses primarily within the field of Biochemistry, Genetics, and Molecular Biology, with a strong emphasis on Molecular Biology. Additional areas of study include Cancer Research, Genetics, and Cardiology and Cardiovascular Medicine.

The main research topics addressed by Susan M. Freier include:

  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • RNA Research and Splicing
  • Advanced biosensing and bioanalysis techniques
  • DNA and Nucleic Acid Chemistry
  • RNA and protein synthesis mechanisms
  • Viral Infections and Immunology Research

Their recent publications span multiple reputable journals and preprint platforms, reflecting ongoing contributions to RNA biology and therapeutic oligonucleotides. Selected papers include:

  • Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy, 2020, Nucleic Acid Therapeutics
  • Antisense oligonucleotides to therapeutically target SARS-CoV-2 infection, 2023, PLoS ONE
  • Antagonism between splicing and microprocessor complex dictates the serum-induced processing of lnc-MIRHG for efficient cell cycle reentry, 2020, RNA
  • Oncogenic Role of THOR, a Conserved Cancer/Testis Long Non-coding RNA, 2023, Cell
  • Chromatin-associated lncRNA-splicing factor condensates regulate hypoxia responsive RNA processing of genes pre-positioned near nuclear speckles, 2024, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors in these research projects include Qinyu Hao, You Jin Song, Supriya G. Prasanth, Kannanganattu V. Prasanth, and Eric E. Swayze. These collaborations indicate interdisciplinary team efforts across molecular biology and cancer research fields.

Their work has been published in several venues, highlighting sustained activity in high-impact journals and archives such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acid Therapeutics
  • PLoS ONE
  • RNA
  • Cell

Susan M. Freier's contributions are situated predominantly within molecular biology, with a detailed focus on RNA processes including splicing, RNA modifications, and antisense technologies. Their research addresses molecular mechanisms underlying cancer as well as therapeutic avenues for viral infections, reflecting a multidisciplinary approach to molecular and cellular biology.

Best Publications

  • miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting.

    Christine Esau;Scott Davis;Susan F. Murray;Xing Xian Yu

  • The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation.

    Vidisha Tripathi;Jonathan D. Ellis;Zhen Shen;David Y. Song

  • Improved free-energy parameters for predictions of RNA duplex stability

    Susan M. Freier;Ryszard Kierzek;John A. Jaeger;Naoki Sugimoto

  • The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically-modified DNA:RNA duplexes

    Susan M. Freier;Karl-Heinz Altmann

  • MicroRNA-143 regulates adipocyte differentiation.

    Christine Esau;Xiaolin Kang;Eigen Peralta;Elaine Hanson

  • Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression

    B P Monia;E A Lesnik;C Gonzalez;W F Lima

  • Patterns of Variant Polyadenylation Signal Usage in Human Genes

    Emmanuel Beaudoing;Susan Freier;Jacqueline R. Wyatt;Jean-Michel Claverie

  • Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB.

    Vidisha Tripathi;Zhen Shen;Arindam Chakraborty;Sumanprava Giri

  • 3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

    Jeremy E. Wilusz;Susan M. Freier;David L. Spector

  • Regulating Gene Expression through RNA Nuclear Retention

    Kannanganattu V. Prasanth;Supriya G. Prasanth;Zhenyu Xuan;Stephen Hearn

  • Antisense oligonucleotides inhibit intercellular adhesion molecule 1 expression by two distinct mechanisms.

    Ming-Yi Chiang;Hedy Chan;M. A. Zounes;S. M. Freier

  • Improved targeting of miRNA with antisense oligonucleotides.

    Scott Davis;Bridget Lollo;Susan Freier;Christine Esau

  • Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

    L L Cummins;S R Owens;L M Risen;E A Lesnik

  • Effects of phosphorothioate capping on antivense oligonucleotide stability, hybridization and antiviral efficacy versus herpes simplex virus infection

    Glenn D. Hoke;Kenneth Draper;Susan M. Freier;Carolyn Gonzalez

  • Selective inhibition of mutant Ha-ras mRNA expression by antisense oligonucleotides.

    B P Monia;J F Johnston;D J Ecker;M A Zounes

  • Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

    Jeffrey B Carroll;Simon C Warby;Amber L Southwell;Crystal N Doty

  • Implication of RNA structure on antisense oligonucleotide hybridization kinetics.

    Walt F. Lima;Brett P. Monia;David J. Ecker;Susan M. Freier

  • Predicting oligonucleotide affinity to nucleic acid targets.

    David H. Mathews;Mark E. Burkard;Susan M. Freier;Jacqueline R. Wyatt

  • Oligodeoxynucleotides containing 2'-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes

    E A Lesnik;C J Guinosso;A M Kawasaki;H Sasmor

  • Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

    Jingyi Fei;Mahdieh Jadaliha;Tyler S. Harmon;Isaac T. S. Li

Frequent Co-Authors

Brett P. Monia
Brett P. Monia Ionis Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
David J. Ecker
David J. Ecker Ionis Pharmaceuticals (United States)
Nicholas M. Dean
Nicholas M. Dean Ionis Pharmaceuticals (United States)
Kannanganattu V. Prasanth
Kannanganattu V. Prasanth University of Illinois at Urbana-Champaign
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Phillip Dan Cook
Phillip Dan Cook Ionis Pharmaceuticals (United States)
Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)
Frank Rigo
Frank Rigo Ionis Pharmaceuticals (United States)

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