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Molecular Biology

D-Index
66
Citations
20479
World Ranking
1604
National Ranking
812

Overview

Frank Rigo is affiliated with Ionis Pharmaceuticals in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology, genetics, and neurology. The scientist's work is distributed across several subfields of study including cellular and molecular neuroscience and cancer research.

Their research portfolio includes topics such as RNA research and splicing, amyotrophic lateral sclerosis (ALS) research, RNA modifications and cancer, neurogenetic and muscular disorders research, genetic neurodegenerative diseases, genetics and neurodevelopmental disorders, and RNA regulation and disease.

Frank Rigo has published extensively in various scientific venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science Translational Medicine
  • Human Molecular Genetics
  • Nucleic Acids Research
  • Cancer Research

Among their recent scientific papers are:

  • Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies, 2023, Science
  • C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy, 2020, Science Translational Medicine
  • G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD, 2020, Neuron
  • Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS, 2021, Nature Biotechnology
  • Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS, 2021, Science Translational Medicine

Frequent coauthors contributing to Frank Rigo's research outputs include:

  • Paymaan Jafar-Nejad
  • Karen Ling
  • C. Frank Bennett
  • Armand Soriano
  • Michaela Jackson

Best Publications

  • Robust transcriptome-wide discovery of RNA-binding protein binding sites with enhanced CLIP (eCLIP)

    Eric L Van Nostrand;Gabriel A Pratt;Alexander A Shishkin;Chelsea Gelboin-Burkhart

  • RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

    Christopher J. Donnelly;Ping-Wu Zhang;Jacqueline T. Pham;Aaron R. Haeusler

  • Treatment of infantile-onset spinal muscular atrophy with nusinersen: a phase 2, open-label, dose-escalation study

    Richard S Finkel;Claudia A Chiriboga;Jiri Vajsar;John W Day

  • Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

    Dhruv Sareen;Jacqueline G. O’Rourke;Pratap Meera;A. K. M. G. Muhammad

  • Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model

    Yimin Hua;Kentaro Sahashi;Frank Rigo;Gene Hung

  • Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model

    Yimin Hua;Kentaro Sahashi;Gene Hung;Frank Rigo

  • Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

    Clotilde Lagier-Tourenne;Michael Baughn;Frank Rigo;Shuying Sun

  • Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

    Lindsay A. Becker;Brenda Huang;Gregor Bieri;Rosanna Ma

  • Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    Jie Jiang;Jie Jiang;Qiang Zhu;Tania F. Gendron;Shahram Saberi

  • Antisense Oligonucleotides Delivered to the Mouse CNS Ameliorate Symptoms of Severe Spinal Muscular Atrophy

    Marco A. Passini;Jie Bu;Amy M. Richards;Cathrine Kinnecom

  • Towards a therapy for Angelman syndrome by targeting a long non-coding RNA

    Linyan Meng;Amanda J. Ward;Seung Chun;C. Frank Bennett

  • Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration.

    Ze’ev Melamed;Jone López-Erauskin;Michael W. Baughn;Ouyang Zhang

  • The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing.

    Guy Barry;J. A. Briggs;D. P. Vanichkina;E. M. Poth

  • Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

    Ke Zhang;J. Gavin Daigle;Kathleen M. Cunningham;Alyssa N. Coyne

  • Antisense oligonucleotide therapy for spinocerebellar ataxia type 2

    Daniel R. Scoles;Pratap Meera;Matthew D. Schneider;Sharan Paul

  • Antisense reduction of tau in adult mice protects against seizures.

    Sarah L. DeVos;Dustin K. Goncharoff;Guo Chen;Carey S. Kebodeaux

  • Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates

    Frank Rigo;Seung J. Chun;Daniel A. Norris;Gene Hung

  • Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

    Tania D Gendron;Jeannie Chew;Jeannette N. Stankowski;Lindsey R. Hayes

  • Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides

    Yehezkel Sztainberg;Hong-mei Chen;John W. Swann;John W. Swann;Shuang Hao

  • Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness

    Jennifer J Lentz;Francine M Jodelka;Anthony J Hinrich;Kate E McCaffrey

Frequent Co-Authors

C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
Adrian R. Krainer
Adrian R. Krainer Cold Spring Harbor Laboratory
David L. Spector
David L. Spector Cold Spring Harbor Laboratory
Jeffrey D. Rothstein
Jeffrey D. Rothstein Johns Hopkins University
David R. Corey
David R. Corey The University of Texas Southwestern Medical Center
Stefan M. Pulst
Stefan M. Pulst University of Utah
Don W. Cleveland
Don W. Cleveland University of California, San Diego
Gene W. Yeo
Gene W. Yeo University of California, San Diego
Nicolas G. Bazan
Nicolas G. Bazan Louisiana State University
Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)

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