World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
19664
World Ranking
16927
National Ranking
6976

Overview

Sergey Leikin is affiliated with the National Institutes of Health in the United States and has conducted extensive research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields including genetics, molecular biology, rheumatology, epidemiology, and physiology.

The scientist's research covers several focused topics related to connective tissue disorders and bone health. These include:

  • Connective tissue disorders research
  • Bone fractures and treatments
  • Bone and Dental Protein Studies
  • Macrophage Migration Inhibitory Factor
  • Protease and Inhibitor Mechanisms
  • Alkaline Phosphatase Research Studies
  • Bone Metabolism and Diseases

Sergey Leikin has contributed to various research articles published in peer-reviewed journals. Notable recent publications include:

  • Mechanisms of procollagen and HSP47 sorting during ER-to-Golgi trafficking (2020, Matrix Biology)
  • 4PBA reduces growth deficiency in osteogenesis imperfecta by enhancing transition of hypertrophic chondrocytes to osteoblasts (2022, JCI Insight)
  • ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts (2022, Advanced Science)
  • Noncanonical ER-Golgi trafficking and autophagy of endogenous procollagen in osteoblasts (2021, Cellular and Molecular Life Sciences)
  • Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia (2020, Matrix Biology)

In their collaborative work, Sergey Leikin frequently coauthors with the following researchers:

  • Elena Makareeva
  • Shakib Omari
  • Laura Gorrell
  • Edward L. Mertz
  • Satoru Otsuru

Sergey Leikin's research has been published repeatedly in certain academic venues, reflecting areas of specialization or ongoing research questions in their career:

  • Matrix Biology
  • JBMR Plus
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight
  • Advanced Science

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Type I collagen is thermally unstable at body temperature.

    E. Leikina;M. V. Mertts;N. Kuznetsova;S. Leikin

  • Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

    Wayne A Cabral;Weizhong Chang;Aileen M Barnes;MaryAnn Weis

  • Deficiency of Cartilage-Associated Protein in Recessive Lethal Osteogenesis Imperfecta

    Aileen M. Barnes;Weizhong Chang;Roy Morello;Wayne A. Cabral

  • Structure and interactions of biological helices

    Alexei A. Kornyshev;Dominic J. Lee;Sergey Leikin;Aaron Wynveen

  • Mutations in WNT1 Cause Different Forms of Bone Fragility

    Katharina Keupp;Filippo Beleggia;Hülya Kayserili;Aileen M. Barnes

  • Measured effects of diacylglycerol on structural and elastic properties of phospholipid membranes.

    S. Leikin;M.M. Kozlov;N.L. Fuller;R.P. Rand

  • Electrostatic Zipper Motif for DNA Aggregation

    A. A. Kornyshev;S. Leikin;S. Leikin

  • Temperature-favoured assembly of collagen is driven by hydrophilic not hydrophobic interactions.

    S Leikin;D C Rau;V A Parsegian

  • Raman spectral evidence for hydration forces between collagen triple helices.

    S. Leikin;V. A. Parsegian;W.-H. Yang;G. E. Walrafen

  • Lack of Cyclophilin B in Osteogenesis Imperfecta with Normal Collagen Folding

    Aileen M. Barnes;Erin M. Carter;Wayne A. Cabral;MaryAnn Weis

  • Theory of interaction between helical molecules

    A. A. Kornyshev;S. Leikin

  • Direct measurement of forces between self-assembled proteins: temperature-dependent exponential forces between collagen triple helices.

    S Leikin;D C Rau;V A Parsegian

  • Noncanonical autophagy at ER exit sites regulates procollagen turnover.

    Shakib Omari;Elena Makareeva;Anna Roberts-Pilgrim;Lynn Mirigian

  • Does the triple helical domain of type I collagen encode molecular recognition and fiber assembly while telopeptides serve as catalytic domains? Effect of proteolytic cleavage on fibrillogenesis and on collagen-collagen interaction in fibers.

    Natalia Kuznetsova;Sergey Leikin

  • Mutations Near Amino End of α1(I) Collagen Cause Combined Osteogenesis Imperfecta/Ehlers-Danlos Syndrome by Interference with N-propeptide Processing *

    Wayne A. Cabral;Elena Makareeva;Alain Colige;Anne D. Letocha

  • Abnormal Type I Collagen Post-translational Modification and Crosslinking in a Cyclophilin B KO Mouse Model of Recessive Osteogenesis Imperfecta

    Wayne A. Cabral;Irina Perdivara;MaryAnn A. Weis;Masahiko Terajima

  • COL1 C-propeptide Cleavage Site Mutations Cause High Bone Mass Osteogenesis Imperfecta

    Katarina Lindahl;Aileen M. Barnes;Nadja Fratzl-Zelman;Michael P. Whyte

  • Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.

    Sejin Han;Elena Makareeva;Natalia V. Kuznetsova;Angela M. DeRidder

  • MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta

    Uschi Lindert;Wayne A. Cabral;Surasawadee Ausavarat;Surasawadee Ausavarat;Surasawadee Ausavarat;Siraprapa Tongkobpetch;Siraprapa Tongkobpetch

Frequent Co-Authors

Joan C. Marini
Joan C. Marini National Institutes of Health
Alexei A. Kornyshev
Alexei A. Kornyshev Imperial College London
David R. Eyre
David R. Eyre University of Washington
MaryAnn Weis
MaryAnn Weis University of Washington
Hideaki Nagase
Hideaki Nagase University of Oxford
Constantine A. Stratakis
Constantine A. Stratakis Foundation for Research and Technology Hellas
Peter H. Byers
Peter H. Byers University of Washington
Atanas G. Atanasov
Atanas G. Atanasov Medical University of Vienna
Philippe Pierre
Philippe Pierre Aix-Marseille University
Pamela Gehron Robey
Pamela Gehron Robey National Institutes of Health

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