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Mario A. Ostrowski

Mario A. Ostrowski

D-Index & Metrics

Immunology

D-Index
68
Citations
18044
World Ranking
2576
National Ranking
56

Overview

Mario A. Ostrowski is affiliated with the University of Toronto in Canada. Their research predominantly focuses on Medicine and Immunology and Microbiology, with a significant number of publications in the infectious diseases subfield, as well as Immunology, Molecular Biology, Virology, and Epidemiology.

The main topics of their work include SARS-CoV-2 and COVID-19 research, COVID-19 clinical research studies, HIV research and treatment, animal virus infections studies, SARS-CoV-2 detection and testing, immunotherapy and immune responses, and immune cell function and interaction.

Ostrowski's recent papers highlight important aspects of the immune response related to SARS-CoV-2 and COVID-19:

  • Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients, 2020, Science Immunology
  • Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein, 2020, Nature Medicine
  • Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection, 2022, Mucosal Immunology
  • A simple protein-based surrogate neutralization assay for SARS-CoV-2, 2020, JCI Insight
  • Sensitivity of Nasopharyngeal Swabs and Saliva for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2, 2020, Clinical Infectious Diseases

Frequent co-authors in Ostrowski's work include Patrick Budylowski, Allison McGeer, Anne-Claude Gingras, Samira Mubareka, and James M. Rini, reflecting a collaborative approach in their research efforts.

Their work has been published multiple times across a variety of scientific venues, including bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Journal of Virology, Nature Communications, and SSRN Electronic Journal.

Ostrowski's publication record shows a consistent focus on infectious diseases and immunology, contributing substantial research in areas related to viral infections and immune response mechanisms.

Best Publications

  • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

    Pereyra F;Jia X;McLaren Pj

  • Mechanism of hard-nanomaterial clearance by the liver

    Kim M. Tsoi;Sonya A. Macparland;Xue Zhong Ma;Vinzent N. Spetzler

  • Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

    R. Brad Jones;Lishomwa C Ndhlovu;Jason D. Barbour;Prameet M. Sheth

  • Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients.

    Baweleta Isho;Kento T. Abe;Kento T. Abe;Michelle Zuo;Alainna J. Jamal;Alainna J. Jamal

  • CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

    Yu-Hwa Huang;Chen Zhu;Yasuyuki Kondo;Ana C. Anderson

  • Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein.

    Seth J. Zost;Pavlo Gilchuk;Rita E. Chen;James Brett Case

  • Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.

    Tae Wook Chun;Richard T. Davey;Mario Ostrowski;J. Shawn Justement

  • Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1.

    Sharilyn K. Stanley;Mario A. Ostrowski;Jesse S. Justement;Kira Gantt

  • Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

    Unknown

  • TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

    Glen M. Chew;Tsuyoshi Fujita;Tsuyoshi Fujita;Gabriela M. Webb;Benjamin J. Burwitz;Benjamin J. Burwitz

  • Rebound of plasma viremia following cessation of antiretroviral therapy despite profoundly low levels of HIV reservoir: implications for eradication.

    Tae Wook Chun;J. Shawn Justement;Danielle Murray;Claire W. Hallahan

  • Disease Progression in Chronic Hepatitis C: Modifiable and Nonmodifiable Factors

    Sharif B. Missiha;Mario Ostrowski;E. Jenny Heathcote

  • Both Memory and CD45RA+/CD62L+ Naive CD4+ T Cells Are Infected in Human Immunodeficiency Virus Type 1-Infected Individuals

    Mario A. Ostrowski;Tae Wook Chun;Shawn J. Justement;Ivette Motola

  • Expression of Chemokine Receptors CXCR4 and CCR5 in HIV-1-Infected and Uninfected Individuals

    Mario A. Ostrowski;Shawn J. Justement;Andrew Catanzaro;Claire A. Hallahan

  • Distinct Transcriptional Profiles in Ex Vivo CD4+ and CD8+ T Cells Are Established Early in Human Immunodeficiency Virus Type 1 Infection and Are Characterized by a Chronic Interferon Response as Well as Extensive Transcriptional Changes in CD8+ T Cells

    Martin D. Hyrcza;Colin Kovacs;Mona Loutfy;Roberta Halpenny

  • CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction.

    Audrey Kinter;Andrew Catanzaro;JoAn Monaco;Margaret Ruiz

  • Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

    Richard Brad Jones;Rachel O'Connor;Stefanie Mueller;Maria Hottelet Foley

  • Phenotype Determines Nanoparticle Uptake by Human Macrophages from Liver and Blood.

    Sonya A. MacParland;Kim M. Tsoi;Ben Ouyang;Xue-Zhong Ma

  • A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis

    C J Kim;A Nazli;O L Rojas;D Chege

  • A simple protein-based surrogate neutralization assay for SARS-CoV-2.

    Kento T. Abe;Zhijie Li;Reuben Samson;Payman Samavarchi-Tehrani

  • Dendritic Cells Express Multiple Chemokine Receptors Used as Coreceptors for HIV Entry

    Andrea Rubbert;Christophe Combadiere;Mario Ostrowski;James Arthos

Frequent Co-Authors

Colin Kovacs
Colin Kovacs University of Toronto
Rupert Kaul
Rupert Kaul University of Toronto
Douglas F. Nixon
Douglas F. Nixon Cornell University
Allison McGeer
Allison McGeer University of Toronto
Lishomwa C. Ndhlovu
Lishomwa C. Ndhlovu Cornell University
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Anthony S. Fauci
Anthony S. Fauci Georgetown University
Jonah B. Sacha
Jonah B. Sacha Oregon Health & Science University
Bruce D. Walker
Bruce D. Walker Harvard University
Steven G. Deeks
Steven G. Deeks University of California, San Francisco

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