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Genetics
UK
2024
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Genetics and Molecular Biology
Netherlands
2024

D-Index & Metrics

Genetics

D-Index
128
Citations
145853
World Ranking
267
National Ranking
49

Medicine

D-Index
126
Citations
145462
World Ranking
2865
National Ranking
292

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Netherlands Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Netherlands Leader Award

Overview

Paul I. W. de Bakker is affiliated with Vertex Pharmaceuticals in the United Kingdom. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, as well as medicine. The scientist's work often focuses on immunology, genetics, molecular biology, cardiology and cardiovascular medicine, and pathology and forensic medicine.

Key topics in Paul I. W. de Bakker's research include:

  • T-cell and B-cell Immunology
  • Genetic Associations and Epidemiology
  • Immune Cell Function and Interaction
  • Lymphoma Diagnosis and Treatment
  • Diabetes and associated disorders
  • Cardiovascular Disease and Adiposity
  • Cardiovascular Function and Risk Factors

The scientist has published a variety of papers, including notable recent works such as:

  • Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease, 2023, Nature Protocols
  • Cystatin C and Cardiovascular Disease: A Mendelian Randomization Study, 2020, UNC Libraries
  • Genome-wide association analysis identifies multiple loci related to resting heart rate, 2020, UNC Libraries
  • A statistical genetics guide to identifying HLA alleles driving complex disease, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk, 2020, Cell

Frequently publishing in venues such as UNC Libraries, Nature Protocols, bioRxiv (Cold Spring Harbor Laboratory), Cell, and Digital Commons@Becker (Washington University School of Medicine), Paul I. W. de Bakker has contributed extensively to the academic discourse in their fields.

Collaboration has played a significant role in their work, with frequent co-authors including:

  • Albert V. Smith
  • Folkert W. Asselbergs
  • Kari E. North
  • Joseph Vijai
  • Roel Vermeulen

The scientist's publication record covers a range of research areas intersecting genetics and immunology, especially studies involving genetic factors in complex diseases and cardiovascular health. Their work includes both empirical investigations and statistical genetics methodologies to better understand disease mechanisms and risk factors.

Best Publications

  • PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses

    Shaun Purcell;Shaun Purcell;Benjamin Neale;Benjamin Neale;Kathe Todd-Brown;Lori Thomas

  • Structure validation by Calpha geometry: phi,psi and Cbeta deviation.

    Simon C. Lovell;Ian W. Davis;W. Bryan Arendall;Paul I. W. de Bakker

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • A haplotype map of the human genome

    John W. Belmont;Andrew Boudreau;Suzanne M. Leal;Paul Hardenbol

  • A second generation human haplotype map of over 3.1 million SNPs

    Kelly A. Frazer;Dennis G. Ballinger;David R. Cox;David A. Hinds

  • Integrating common and rare genetic variation in diverse human populations

    D M Altshuler;R A Gibbs;L Peltonen

  • A reference panel of 64,976 haplotypes for genotype imputation

    Shane McCarthy;Sayantan Das;Warren Kretzschmar;Olivier Delaneau

  • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

    Stephen Sawcer;Garrett Hellenthal;Matti Pirinen;Chris C. A. Spencer

  • Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

    Richa Saxena;Benjamin F. Voight;Valeriya Lyssenko;Noël P. Burtt

  • Risk alleles for multiple sclerosis identified by a genomewide study.

    David A. Hafler;Alastair Compston;Stephen Sawcer;Mark J. Daly

  • Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study

    Benjamin F. Voight;Benjamin F. Voight;Benjamin F. Voight;Gina M. Peloso;Gina M. Peloso;Marju Orho-Melander;Ruth Frikke-Schmidt

  • Genome-wide detection and characterization of positive selection in human populations

    Pardis C. Sabeti;Pardis C. Sabeti;Patrick Varilly;Patrick Varilly;Ben Fry;Jason Lohmueller

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • Efficiency and power in genetic association studies

    Paul I W de Bakker;Roman Yelensky;Roman Yelensky;Itsik Pe'er;Itsik Pe'er;Stacey B Gabriel

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

    Pereyra F;Jia X;McLaren Pj

  • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

    Eli A Stahl;Soumya Raychaudhuri;Soumya Raychaudhuri;Elaine F Remmers;Gang Xie

  • Common variants at 30 loci contribute to polygenic dyslipidemia.

    Sekar Kathiresan;Sekar Kathiresan;Sekar Kathiresan;Cristen J. Willer;Gina M. Peloso;Serkalem Demissie

  • SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

    Andrew D. Johnson;Robert E. Handsaker;Sara L. Pulit;Marcia M. Nizzari

  • STAT4 and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    Elaine F. Remmers;Robert M. Plenge;Annette T. Lee;Robert R. Graham;Robert R. Graham

Frequent Co-Authors

Mark J. Daly
Mark J. Daly Massachusetts General Hospital
Nilesh J. Samani
Nilesh J. Samani University of Leicester
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam
Albert Hofman
Albert Hofman Harvard University
Cisca Wijmenga
Cisca Wijmenga University Medical Center Groningen
Pim van der Harst
Pim van der Harst University Medical Center Utrecht
David Altshuler
David Altshuler Harvard University
Bruce M. Psaty
Bruce M. Psaty University of Washington

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