H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Immunology D-index 57 Citations 10,113 125 World Ranking 2066 National Ranking 51

Research.com Recognitions

Awards & Achievements

1963 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Virus

The scientist’s investigation covers issues in Virology, Immunology, Viral replication, Virus and Human leukocyte antigen. Mark A. Brockman interconnects Epitope and Genetics, Gene, Immune system in the investigation of issues within Virology. His studies examine the connections between Epitope and genetics, as well as such issues in CTL*, with regards to Reverse transcriptase.

His biological study deals with issues like Cytotoxic T cell, which deal with fields such as Cytokine secretion. His Viral replication research integrates issues from Mutation, Viremia and CD8. His Human leukocyte antigen research includes themes of Allele and Group-specific antigen.

His most cited work include:

  • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. (417 citations)
  • Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction. (417 citations)
  • Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. (290 citations)

What are the main themes of his work throughout his whole career to date?

Mark A. Brockman mostly deals with Virology, Immunology, Human leukocyte antigen, Viral replication and Immune system. His Virology research is multidisciplinary, relying on both Epitope, T cell and Cytotoxic T cell, CTL*. Mark A. Brockman has included themes like Molecular biology, Cytokine secretion and Avidity in his Cytotoxic T cell study.

His studies in Human leukocyte antigen integrate themes in fields like Cellular immunity, Downregulation and upregulation, CD8 and Allele. He focuses mostly in the field of Viral replication, narrowing it down to topics relating to Viremia and, in certain cases, Infectivity. Mark A. Brockman works mostly in the field of Immune system, limiting it down to topics relating to Antibody and, in certain cases, Bioinformatics and Flow cytometry.

He most often published in these fields:

  • Virology (88.56%)
  • Immunology (55.22%)
  • Human leukocyte antigen (55.72%)

What were the highlights of his more recent work (between 2018-2021)?

  • Virology (88.56%)
  • Viral pathogenesis (9.95%)
  • Downregulation and upregulation (17.91%)

In recent papers he was focusing on the following fields of study:

Mark A. Brockman mainly investigates Virology, Viral pathogenesis, Downregulation and upregulation, Immunology and T cell. The concepts of his Virology study are interwoven with issues in Disease progression and Genetic diversity. His Downregulation and upregulation research incorporates themes from Infectivity, Human leukocyte antigen, CTL* and Allele.

His research integrates issues of Mutation and Mutagenesis in his study of CTL*. His research in Immune system and Neutralizing antibody are components of Immunology. His work investigates the relationship between T cell and topics such as CD8 that intersect with problems in Viremia and Interleukin-7 receptor.

Between 2018 and 2021, his most popular works were:

  • Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. (25 citations)
  • HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals. (13 citations)
  • HIV Subtype and Nef-Mediated Immune Evasion Function Correlate with Viral Reservoir Size in Early-Treated Individuals. (13 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Immune system

His primary scientific interests are in Downregulation and upregulation, Virology, Immune system, Cart and Viral pathogenesis. The Downregulation and upregulation study combines topics in areas such as Infectivity and Human leukocyte antigen. His studies deal with areas such as Viral entry, Nonsynonymous substitution and Antibody as well as Human leukocyte antigen.

His Virology study combines topics from a wide range of disciplines, such as Genetic diversity, Phylogenetic diversity, Phylogenetic tree and Subgenomic mRNA, Genome. His Immune system study results in a more complete grasp of Immunology. His study in Immunology focuses on Interleukin-7 receptor in particular.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.

Daniel E Kaufmann;Daniel G Kavanagh;Florencia Pereyra;Florencia Pereyra;John J Zaunders.
Nature Immunology (2007)

557 Citations

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

Arne Schneidewind;Mark A. Brockman;Mark A. Brockman;Ruifeng Yang;Rahma I. Adam.
Journal of Virology (2007)

362 Citations

Escape and Compensation from Early HLA-B57-Mediated Cytotoxic T-Lymphocyte Pressure on Human Immunodeficiency Virus Type 1 Gag Alter Capsid Interactions with Cyclophilin A

Mark A. Brockman;Arne Schneidewind;Matthew Lahaie;Aaron Schmidt;Aaron Schmidt.
Journal of Virology (2007)

304 Citations

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells.

Mark A. Brockman;Mark A. Brockman;Douglas S. Kwon;Douglas S. Kwon;Douglas S. Kwon;Daniel P. Tighe;David F. Pavlik.
Blood (2009)

267 Citations

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition

Toshiyuki Miura;Toshiyuki Miura;Mark A. Brockman;Arne Schneidewind;Michael Lobritz.
Journal of Virology (2009)

251 Citations

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

Huabiao Chen;Zaza M Ndhlovu;Zaza M Ndhlovu;Dongfang Liu;Lindsay C Porter.
Nature Immunology (2012)

233 Citations

Herpes simplex virus.

Travis J Taylor;Mark A Brockman;Elizabeth E McNamee;David M Knipe.
Frontiers in Bioscience (2002)

196 Citations

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

Zabrina L. Brumme;Zabrina L. Brumme;Mina John;Jonathan M. Carlson;Chanson J. Brumme.
PLOS ONE (2009)

187 Citations

Structural and Functional Constraints Limit Options for Cytotoxic T-Lymphocyte Escape in the Immunodominant HLA-B27-Restricted Epitope in Human Immunodeficiency Virus Type 1 Capsid

Arne Schneidewind;Mark A. Brockman;Mark A. Brockman;John Sidney;Yaoyu E. Wang.
Journal of Virology (2008)

175 Citations

Responsiveness of HIV-specific CD4 T cells to PD-1 blockade

Filippos Porichis;Douglas S. Kwon;Douglas S. Kwon;Douglas S. Kwon;Jennifer Zupkosky;Daniel P. Tighe.
Blood (2011)

167 Citations

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