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Alicja Trocha

Alicja Trocha

Ragon Institute of MGH, MIT and Harvard
United States

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Immune system
  • Virus

The scientist’s investigation covers issues in Virology, Immunology, CTL*, Human leukocyte antigen and Viremia. The study incorporates disciplines such as Epitope and Immune system in addition to Virology. Her work is dedicated to discovering how Epitope, Mutation are connected with Interferon and Group-specific antigen and other disciplines.

As part of her studies on Human leukocyte antigen, Alicja Trocha often connects relevant subjects like CD8. Her CD8 research includes elements of T cell, Aldesleukin, Acquired immunodeficiency syndrome and HIV Long-Term Survivors. In her study, Cd4 cell count and Epitope mapping is strongly linked to RNA, which falls under the umbrella field of Viral load.

Her most cited work include:

  • Evolution and transmission of stable CTL escape mutations in HIV infection (513 citations)
  • Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy (446 citations)
  • Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy (446 citations)

What are the main themes of her work throughout her whole career to date?

Alicja Trocha mainly focuses on Virology, Immunology, CTL*, Epitope and Human leukocyte antigen. Alicja Trocha focuses mostly in the field of Virology, narrowing it down to topics relating to Immune system and, in certain cases, Viral infection. Her research on Immunology often connects related areas such as Acquired immunodeficiency syndrome.

Her biological study spans a wide range of topics, including ELISPOT, T cell, Peptide sequence and Molecular biology. Her studies in Human leukocyte antigen integrate themes in fields like Immunotherapy, Allele, Conserved sequence and Group-specific antigen. Her Viral replication research incorporates themes from Mutation and Lentivirus.

She most often published in these fields:

  • Virology (119.67%)
  • Immunology (83.61%)
  • CTL* (60.66%)

What were the highlights of her more recent work (between 2008-2021)?

  • Virology (119.67%)
  • Immunology (83.61%)
  • Viral replication (44.26%)

In recent papers she was focusing on the following fields of study:

Her main research concerns Virology, Immunology, Viral replication, Viremia and Elite controllers. Her Virology research integrates issues from Epitope and CTL*. Her Immunology study incorporates themes from Hiv infected and Bioinformatics.

Her Viral replication research is multidisciplinary, relying on both Transmission, Human leukocyte antigen and Art initiation, Antiretroviral therapy. Her Human leukocyte antigen study deals with Group-specific antigen intersecting with Viral disease. Her Viremia research is multidisciplinary, incorporating perspectives in Mutation, APOBEC3G, Infectivity and Lentivirus.

Between 2008 and 2021, her most popular works were:

  • HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition (251 citations)
  • HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition (251 citations)
  • Impaired Replication Capacity of Acute/Early Viruses in Persons Who Become HIV Controllers (120 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Virus

Alicja Trocha spends much of her time researching Viremia, Viral replication, Virology, Immunology and Group-specific antigen. Alicja Trocha interconnects Viral disease, CTL*, Viral load and HIV Long-Term Survivors in the investigation of issues within Viral replication. Her CTL* research is multidisciplinary, incorporating elements of Epitope, Interferon and Mutation.

Her Viral load study improves the overall literature in Virus. Alicja Trocha has included themes like Chronic infection and Drug resistance in her HIV Long-Term Survivors study. Her research on Group-specific antigen often connects related topics like Human leukocyte antigen.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Evolution and transmission of stable CTL escape mutations in HIV infection

Philip J. R. Goulder;Christian Brander;Yanhua Tang;Cecile Tremblay.
Nature (2001)

690 Citations

Genetic and Immunologic Heterogeneity among Persons Who Control HIV Infection in the Absence of Therapy

Florencia Pereyra;Marylyn M. Addo;Daniel E. Kaufmann;Yang Liu.
(2008)

616 Citations

Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load.

T Harrer;E Harrer;S A Kalams;P Barbosa.
Journal of Immunology (1996)

482 Citations

Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection.

Spyros A. Kalams;S. P. Buchbinder;E. S. Rosenberg;J. M. Billingsley.
Journal of Virology (1999)

469 Citations

Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy.

Spyros A. Kalams;Philip J. Goulder;Amy K. Shea;Norman G. Jones.
Journal of Virology (1999)

455 Citations

Suppression of human immunodeficiency virus type 1 replication by CD8+ cells: evidence for HLA class I-restricted triggering of cytolytic and noncytolytic mechanisms.

O O Yang;S A Kalams;A Trocha;H Cao.
Journal of Virology (1997)

431 Citations

Efficient lysis of human immunodeficiency virus type 1-infected cells by cytotoxic T lymphocytes.

O O Yang;S A Kalams;M Rosenzweig;A Trocha.
Journal of Virology (1996)

273 Citations

HIV-1 gag-specific cytotoxic T lymphocytes recognize multiple highly conserved epitopes. Fine specificity of the gag-specific response defined by using unstimulated peripheral blood mononuclear cells and cloned effector cells.

R. P. Johnson;A. Trocha;Lin Yang;G. P. Mazzara.
Journal of Immunology (1991)

270 Citations

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphocyte Recognition.

Toshiyuki Miura;Mark A. Brockman;Arne Schneidewind;Michael Lobritz.
Journal of Virology (2009)

266 Citations

Longitudinal analysis of T cell receptor (TCR) gene usage by human immunodeficiency virus 1 envelope-specific cytotoxic T lymphocyte clones reveals a limited TCR repertoire.

S A Kalams;R P Johnson;A K Trocha;M J Dynan.
Journal of Experimental Medicine (1994)

250 Citations

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