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Deborah L. Zink

Deborah L. Zink

D-Index & Metrics

Chemistry

D-Index
57
Citations
7863
World Ranking
11417
National Ranking
831

Biology and Biochemistry

D-Index
57
Citations
7762
World Ranking
14115
National Ranking
994

Overview

Deborah L. Zink is affiliated with Justus-Liebig University of Giessen in Germany. Their research encompasses multiple disciplines, primarily focusing on areas within computer science as well as biochemistry, genetics, and molecular biology.

The scientist's work navigates subfields including computational theory and mathematics alongside molecular biology. These overlapping domains reflect a multidisciplinary approach to research and contribute to understanding complex biological systems through computational methods.

Their scholarly output includes publications addressing computational drug discovery methods and the study of 14-3-3 protein interactions. These topics highlight interest in molecular mechanisms and the application of computational tools for drug development and molecular interaction analysis.

  • Computational Drug Discovery Methods
  • 14-3-3 protein interactions

Among their recent papers, one notable publication is titled From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9, published in 2021 in the journal Cell chemical biology. This work contributes to the field of molecular biology and chemical biology by addressing strategies for identifying and improving small molecule ligands targeting PCSK9, a protein of significant interest in cardiovascular and lipid regulation research.

  • From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9 (2021, Cell chemical biology)

Throughout their research career, Deborah L. Zink has collaborated with various scholars, reflecting engagement with diverse expertise. Frequent co-authors include Whitney L. Petrilli, Gregory C. Adam, Roman S. Erdmann, Pravien Abeywickrema, and Vijayalakshmi Agnani.

  • Whitney L. Petrilli
  • Gregory C. Adam
  • Roman S. Erdmann
  • Pravien Abeywickrema
  • Vijayalakshmi Agnani

Their publication venues are also focused within specialized journals, with at least one published work appearing in Cell chemical biology. This reflects specialization in chemical biology-focused research dissemination.

Best Publications

  • Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

    Sheo B Singh;Hiranthi Jayasuriya;John G Ondeyka;Kithsiri B Herath

  • Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

    Hiranthi Jayasuriya;Kithsiri B. Herath;Chaowei Zhang;Deborah L. Zink

  • Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

    Sheo B. Singh;Deborah L. Zink;Michael A. Goetz;Anne W. Dombrowski

  • Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations

    John G. Ondeyka;Gregory L. Helms;Otto D. Hensens;Michael A. Goetz

  • Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

    John W. Phillips;Michael A. Goetz;Scott K. Smith;Deborah L. Zink

  • Structure and Chemistry of Apicidins, a Class of Novel Cyclic Tetrapeptides without a Terminal α-Keto Epoxide as Inhibitors of Histone Deacetylase with Potent Antiprotozoal Activities

    Sheo B. Singh;Deborah L. Zink;Jerrold M. Liesch;Ralph T. Mosley

  • Apicidins: Novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum

    Sheo B. Singh;Deborah L. Zink;Jon D. Polishook;Anne W. Dombrowski

  • Resorcylic Acid Lactones: Naturally Occurring Potent and Selective Inhibitors of MEK

    Annie Zhao;Seok H. Lee;Seok H. Lee;Marina Moiena;Rosalind G. Jenkins

  • Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: farnesyl pyrophosphate mimic inhibitors of ras farnesyl-protein transferase

    Sheo B. Singh;Deborah L. Zink;Jerrold M. Liesch;Michael A. Goetz

  • Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites

    Sheo B. Singh;Hiranthi Jayasuriya;Raymond Dewey;Jon D. Polishook

  • The complestatins as HIV-1 integrase inhibitors. Efficient isolation, structure elucidation, and inhibitory activities of isocomplestatin, chloropeptin I, new complestatins, A and B, and acid-hydrolysis products of chloropeptin I.

    Sheo B. Singh;Hiranthi Jayasuriya;Gino M. Salituro;Deborah L. Zink

  • Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase

    Sheo B. Singh;Deborah L. Zink;Jerrold M. Liesch;Richard G. Ball

  • Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.

    Craig A. Parish;Scott K. Smith;Kathleen Calati;Deborah Zink

  • Pramanicin, a novel antimicrobial agent from a fungal fermentation

    Robert E. Schwartz;Gregory L. Helms;Evon A. Bolessa;Kenneth E. Wilson

  • Structure and absolute stereochemistry of HIV-1 integrase inhibitor integric acid. A novel eremophilane sesquiterpenoid produced by a Xylaria sp.

    Sheo B. Singh;Deborah Zink;Jon Polishook;Delia Valentino

  • Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

    John G Ondeyka;Deborah L Zink;Katherine Young;Ronald Painter

  • Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. that Inhibits HIV-1 Integrase

    Sheo B. Singh;Deborah L. Zink;Brian Heimbach;Olga Genilloud

  • Unusual cyclopropane-containing hapalindolinones from a cultured cyanobacterium

    Robert E. Schwartz;Charles F. Hirsch;James P. Springer;Douglas J. Pettibone

  • Isolation and structure of nodulisporic acid A1 and A2, novel insecticides from a Nodulisporium sp.

    Otto D. Hensens;John G. Ondeyka;Anne W. Dombrowski;Dan A. Ostlind

  • Novel nematocidal agents from Curcuma comosa.

    Tannis M. Jurgens;Easter G. Frazier;James M. Schaeffer;Tracey E. Jones

Frequent Co-Authors

Sheo B. Singh
Sheo B. Singh MSD (United States)
Gerald F. Bills
Gerald F. Bills The University of Texas Health Science Center at Houston
Fernando Pelaez
Fernando Pelaez Spanish National Cancer Research Centre
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Robert E. Schwartz
Robert E. Schwartz Cornell University
Maria L. Garcia
Maria L. Garcia MSD (United States)
Richard G. Ball
Richard G. Ball MSD (United States)
Dennis M. Schmatz
Dennis M. Schmatz MSD (United States)
Gregory J. Kaczorowski
Gregory J. Kaczorowski MSD (United States)
George M. Garrity
George M. Garrity Michigan State University

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