Richard G. Ball

Overview

Best Publications

• Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

  Sheo B Singh;Hiranthi Jayasuriya;John G Ondeyka;Kithsiri B Herath

  296
  Citations

• Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

  Anne B Eldrup;Marija Prhavc;Jennifer Brooks;Balkrishen Bhat

  241
  Citations

• Synthesis and structure of dicarbonylbis(.eta.-pentamethylcyclopentadienyl)diiridium

  Unknown

  231
  Citations

• Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations

  John G. Ondeyka;Gregory L. Helms;Otto D. Hensens;Michael A. Goetz

  203
  Citations

• Total Synthesis and Determination of the Absolute Configuration of Epibatidine

  Stephen R. Fletcher;Raymond Baker;Mark S. Chambers;Richard H. Herbert

  192
  Citations

• Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

  Paul J. Coleman;John D. Schreier;Christopher D. Cox;Michael J. Breslin

  173
  Citations

• Piperidine-ether based hNK1 antagonists 1: Determination of the relative and absolute stereochemical requirements

  T. Harrison;B.J. Williams;C.J. Swain;R.G. Ball

  171
  Citations

• 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels

  Ian Collins;Christopher Moyes;William B Davey;Michael Rowley

  155
  Citations

• A novel 3-substituted benzazepinone growth hormone secretagogue (L-692,429).

  William R. Schoen;Judith M. Pisano;Kristine Prendergast;Matthew J. Wyvratt

  145
  Citations

• 1-(((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor

  Peter D. Williams;Paul S. Anderson;Richard G. Ball;Mark G. Bock

  135
  Citations

• Aryl sulfones : A new class of γ-secretase inhibitors

  Martin Teall;Paul Oakley;Timothy Harrison;Duncan Shaw

  116
  Citations

• Preussomerins and Deoxypreussomerins: Novel Inhibitors of Ras Farnesyl-Protein Transferase

  Sheo B. Singh;Deborah L. Zink;Jerrold M. Liesch;Richard G. Ball

  116
  Citations

• Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation.

  Craig A. Parish;Scott K. Smith;Kathleen Calati;Deborah Zink

  115
  Citations

• Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas.

  José L. Castro;Richard G. Ball;Howard B. Broughton;Michael G. N. Russell

  111
  Citations

• Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.

  Richard W Friesen;Yves Ducharme;Richard G Ball;Marc Blouin

  106
  Citations

• Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

  Scott D. Edmondson;Cheng Zhu;Nam Fung Kar;Jerry Di Salvo

  105
  Citations

• Activation of dihydrogen by ruthenium(II)-chelating phosphine complexes, and activation of dioxygen by ruthenium(II) porphyrin complexes: an update

  Brian R. James;A. Pacheco;S.J. Rettig;I.S. Thorburn

  97
  Citations

• Methoxylation of cocaine reduces binding affinity and produces compounds of differential binding and dopamine uptake inhibitory activity: discovery of a weak cocaine "antagonist"

  Daniele Simoni;Johannes Stoelwinder;Alan P. Kozikowski;Kenneth M. Johnson

  94
  Citations

• Zaragozic acid A, a potent inhibitor of squalene synthase: initial chemistry and absolute stereochemistry

  Kenneth E. Wilson;Robert M. Burk;Tesfaye Biftu;Richard G. Ball

  93
  Citations

• An Efficient Preparation of Vinamidinium Hexafluorophosphate Salts

  Ian W. Davies;Jean-Francois Marcoux;Jimmy Wu;Michael Palucki

  93
  Citations

• Asymmetric Synthesis of α,α-Difluoro-β-amino Acid Derivatives from Enantiomerically Pure <i>N-tert-</i>Butylsulfinimines

  Unknown

  93
  Citations

• Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage.

  Richard T. Lewis;Angus M. Macleod;Kevin J. Merchant;Fintan Kelleher

  92
  Citations

• Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid

  Alex M. Chen;Martha E. Ellison;Andrey Peresypkin;Robert M. Wenslow

  88
  Citations