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Arthur A. Patchett

Arthur A. Patchett

D-Index & Metrics

Chemistry

D-Index
72
Citations
24037
World Ranking
5167
National Ranking
1606

Research.com Recognitions

  • 2011 - Fellow of the American Chemical Society
  • 2007 - NAS Award for Chemistry in Service to Society, U.S. National Academy of Sciences For innovative contributions in discoveries of Mevacor, the first statin that lowers cholesterol levels, and of Vasotec and Prinivil for treating hypertension and congestive heart failure.
  • 1994 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Arthur A. Patchett is affiliated with MSD in the United States. Their professional focus lies within the context of MSD's therapeutic and pharmaceutical research activities.

Throughout their career, Arthur A. Patchett has been recognized with several awards. These include being named a Fellow of the American Chemical Society in 2011 and a Fellow of the American Association for the Advancement of Science (AAAS) in 1994. In 2007, they received the NAS Award for Chemistry in Service to Society from the U.S. National Academy of Sciences. This award was presented for innovative contributions leading to the discovery of Mevacor, the first statin medication to lower cholesterol levels, as well as Vasotec and Prinivil, drugs used to treat hypertension and congestive heart failure.

No recent papers, frequent co-authors, publication venues, book publications, or detailed data on specific fields or topics of study have been recorded. The available information underscores contributions to medicinal chemistry and pharmaceutical drug development, particularly with a focus on cardiovascular and cholesterol-related therapies.

Best Publications

  • A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release

    Andrew D. Howard;Scott D. Feighner;Doris F. Cully;Joseph P. Arena

  • Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

    A W Alberts;J Chen;G Kuron;V Hunt

  • A new class of angiotensin-converting enzyme inhibitors

    Patchett Aa;Harris E;Tristram Ew;Wyvratt Mj

  • Peptidomimetic regulation of growth hormone secretion.

    Roy G. Smith;Lex H. T. Van der Ploeg;Andrew D. Howard;Scott D. Feighner

  • Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry

    Susan P. Rohrer;Elizabeth T. Birzin;Ralph T. Mosley;Scott C. Berk

  • Antibacterial agents that inhibit lipid A biosynthesis

    H. Russell Onishi;Barbara A. Pelak;Lynn S. Gerckens;Lynn L. Silver

  • Receptor for motilin identified in the human gastrointestinal system.

    Scott D. Feighner;Carina P. Tan;Karen Kulju McKee;Oksana C. Palyha

  • Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue

    A A Patchett;R P Nargund;J R Tata;M H Chen

  • Aminoacid derivatives as antihypertensives

    Elbert E. Harris;Arthur A. Patchett;Edward W. Tristram;Matthew J. Wyvratt

  • A potent nonpeptide cholecystokinin antagonist selective for peripheral tissues isolated from Aspergillus alliaceus.

    RS Chang;VJ Lotti;RL Monaghan;J Birnbaum

  • Chapter 26. Privileged structures — An update

    Arthur A. Patchett;Ravi P. Nargund

  • Orphan G-protein-coupled receptors and natural ligand discovery

    Andrew D Howard;George McAllister;Scott D Feighner;Qingyun Liu

  • A role for the melanocortin 4 receptor in sexual function.

    Lex H. T. Van der Ploeg;William J. Martin;Andrew D. Howard;Ravi P. Nargund

  • Recent developments in the design of angiotensin-converting enzyme inhibitors.

    Matthew J. Wyvratt;Arthur A. Patchett

  • Allele-specific activation of genetically engineered receptors.

    C D Strader;T Gaffney;E E Sugg;M R Candelore

  • Identification of a new G-protein-linked receptor for growth hormone secretagogues

    Sheng-Shung Pong;Lee-Yuh P. Chaung;Dennis C. Dean;Ravi P. Nargund

  • Substituted imidazo-fused 6-membered heterocycles as angiotensin ii antagonists

    Prasun K. Chakravarty;William J. Greenlee;Nathan B. Mantlo;Arthur A. Patchett

  • Phosphonomycin: Structure and Synthesis

    B. G. Christensen;W. J. Leanza;T. R. Beattie;A. A. Patchett

  • Carboxyl-terminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin-converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422.

    M A Cascieri;H G Bull;R A Mumford;A A Patchett

  • Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them

    Arthur A. Patchett;Elbert E. Harris;Matthew J. Wyvratt;Edward W. Tristram

Frequent Co-Authors

William J. Greenlee
William J. Greenlee MSD (United States)
Roy G. Smith
Roy G. Smith Scripps Research Institute
Matthew J. Wyvratt
Matthew J. Wyvratt Medicines for Malaria Venture
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
Andrew D. Howard
Andrew D. Howard MSD (United States)
Lex H.T. Van der Ploeg
Lex H.T. Van der Ploeg MSD (United States)
James M. Schaeffer
James M. Schaeffer MSD (United States)
Michael H. Fisher
Michael H. Fisher MSD (United States)
David H. Weinberg
David H. Weinberg The Ohio State University

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