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Chemistry

D-Index
69
Citations
17934
World Ranking
6156
National Ranking
1874

Overview

Malcolm Maccoss is affiliated with MSD in the United States. Their research contributions span several domains within medicine including pharmacology, public health, computational theory, and chemistry. Their work frequently appears in prominent journals such as the Journal of Medicinal Chemistry and Frontiers in Chemistry.

The scientist's primary fields of study include Medicine, with specific subfields covering Public Health, Environmental and Occupational Health, Pharmacology, Computational Theory and Mathematics, Organic Chemistry, and Statistics and Probability.

Maccoss's research focuses mainly on areas such as Computational Drug Discovery Methods, Pharmacogenetics and Drug Metabolism, Statistical Methods in Clinical Trials, Malaria Research and Control, Research on Leishmaniasis Studies, Mosquito-borne Diseases and Control, and Click Chemistry and Applications.

Among their recent papers are:

  • Rings in Clinical Trials and Drugs: Present and Future (2022), Journal of Medicinal Chemistry
  • Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 (2022), Journal of Medicinal Chemistry
  • Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules (2021), Frontiers in Chemistry

Frequent collaborators include José L. Castro, Alastair D. G. Lawson, Richard D. Taylor, Jonathan Shearer, and Martin A. Lowe. These coauthors have contributed to multiple publications with Maccoss, highlighting a collaborative approach in their scientific work.

The scientist's publication record includes multiple articles in the Journal of Medicinal Chemistry and Frontiers in Chemistry, reflecting continued engagement with medicinal chemistry and chemical biology fields.

Best Publications

  • Rings in Drugs

    Richard D. Taylor;Malcolm MacCoss;Alastair D. G. Lawson

  • Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

    Mark S. Kramer;Neal Cutler;John Feighner;Ram Shrivastava

  • Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

    S. Steven Rahway Carroll;Malcolm Rahway Maccoss;B. David Rahway Olsen;Balkrishen Carlsbad Bhat

  • Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

    Steven S. Carroll;Joanne E. Tomassini;Michele Bosserman;Krista Getty

  • Rings in Clinical Trials and Drugs: Present and Future

    Unknown

  • Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro

    Giovanni Migliaccio;Joanne E. Tomassini;Steven S. Carroll;Licia Tomei

  • A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

    David B. Olsen;Anne B. Eldrup;Linda Bartholomew;Balkrishen Bhat

  • Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

    J. J. Hale;S. G. Mills;M. Maccoss;P. E. Finke

  • Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase

    Anne B Eldrup;Charles R Allerson;C Frank Bennett;Sanjib Bera

  • Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

    Anne B Eldrup;Marija Prhavc;Jennifer Brooks;Balkrishen Bhat

  • Morpholine and thiomorpholine tachykinin receptor antagonists

    Conrad P. Dorn;Paul E. Finke;Jeffrey J. Hale;Malcolm MacCoss

  • Potent, orally absorbed glucagon receptor antagonists.

    Stephen E. de Laszlo;Candice Hacker;Bing Li;Dooseop Kim

  • Pyrrolidine modulators of chemokine receptor activity

    Charles Caldwell;Kevin T. Chapman;Jeffrey Hale;Dooseop Kim

  • Pyrrolidine and piperidine modulators of chemokine receptor activity

    Richard J. Budhu;Jeffrey J. Hale;Edward Holson;Christopher Lynch

  • Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.

    Dooseop Kim;Liping Wang;Jeffrey J. Hale;Christopher L. Lynch

  • New substituted azetidinones as anti-inflammatory and antidegenerative agents

    Malcolm Maccoss;Philippe L. Durette

  • Substituted 2-aminopyridines as inhibitors of nitric oxide synthase

    Craig K. Esser;William K. Hagmann;William F. Hoffman;Shrenik K. Shah

  • The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

    F.D Tattersall;W Rycroft;M Cumberbatch;G Mason

  • Pyrroles and other heterocycles as inhibitors of P38 kinase

    Stephen E. de Laszlo;Denise Visco;Lily Agarwal;Linda Chang

  • Substituted Imidazoles as Glucagon Receptor Antagonists

    Linda L. Chang;Kelly L. Sidler;Margaret A. Cascieri;Stephen de Laszlo

  • Spiro-substituted azacycles as modulators of chemokine receptor activity

    Sander G. Mills;Malcolm MacCoss;Martin S. Springer

Frequent Co-Authors

Sander G. Mills
Sander G. Mills MSD (United States)
Jeffrey J. Hale
Jeffrey J. Hale MSD (United States)
David B. Olsen
David B. Olsen MSD (United States)
Margaret A. Cascieri
Margaret A. Cascieri MSD (United States)
Ann E. Weber
Ann E. Weber MSD (United States)
Arthur A. Patchett
Arthur A. Patchett MSD (United States)
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
William J. Greenlee
William J. Greenlee MSD (United States)
Michael W. Miller
Michael W. Miller MSD (United States)

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