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Biology and Biochemistry

D-Index
55
Citations
11188
World Ranking
15031
National Ranking
6289

Overview

David B. Olsen is affiliated with MSD (United States) and conducts research mainly within the field of Medicine, with a significant focus on Infectious Diseases, Epidemiology, Public Health, Environmental and Occupational Health, Molecular Biology, and Computational Theory and Mathematics.

The scientist's research covers several major topics, including:

  • Malaria Research and Control
  • Computational Drug Discovery Methods
  • Tuberculosis Research and Epidemiology
  • SARS-CoV-2 and COVID-19 Research
  • Mycobacterium research and diagnosis
  • SARS-CoV-2 detection and testing
  • Trypanosoma species research and implications

Olsen has contributed to multiple publications across frequent venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • ACS Infectious Diseases
  • Antimicrobial Agents and Chemotherapy
  • SSRN Electronic Journal
  • PLoS Pathogens

Some recent papers authored or co-authored by Olsen include:

  • SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development (2021, PLoS Pathogens)
  • Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle (2020, Cell Host & Microbe)
  • Generation of SARS-CoV-2 reporter replicon for high-throughput antiviral screening and testing (2021, Proceedings of the National Academy of Sciences)
  • The Tuberculosis Drug Accelerator at year 10: what have we learned? (2021, Nature Medicine)
  • Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax (2022, Structure)

Frequent co-authors collaborating with Olsen include:

  • Nicholas Murgolo
  • John A. McCauley
  • Christopher W. Boyce
  • Anna Ngo
  • Alan F. Cowman

Best Publications

  • Kinetic characterization of ribonuclease-resistant 2'-modified hammerhead ribozymes.

    Wolfgang A. Pieken;David B. Olsen;Fritz Benseler;Helle Aurup

  • L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase.

    S D Young;S F Britcher;L O Tran;L S Payne

  • Inhibition of Hepatitis C Virus RNA Replication by 2′-Modified Nucleoside Analogs

    Steven S. Carroll;Joanne E. Tomassini;Michele Bosserman;Krista Getty

  • Characterization of Resistance to Non-obligate Chain-terminating Ribonucleoside Analogs That Inhibit Hepatitis C Virus Replication in Vitro

    Giovanni Migliaccio;Joanne E. Tomassini;Steven S. Carroll;Licia Tomei

  • Nukleosiidhend, seda sisaldav farmatseutiline kompositsioon ning hendi kasutamine viiruse RNA-s?ltuva RNA polmeraasi inhibiitorina toimiva ravimi valmistamiseks

    Carroll Steven S;Maccoss Malcolm;Olsen David B;Bhat Balkrishen

  • MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

    Vincenzo Summa;Steven W. Ludmerer;John A. McCauley;Christine Fandozzi

  • A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

    David B. Olsen;Anne B. Eldrup;Linda Bartholomew;Balkrishen Bhat

  • Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase

    Anne B Eldrup;Charles R Allerson;C Frank Bennett;Sanjib Bera

  • Discovery of MK-8742: an HCV NS5A inhibitor with broad genotype activity.

    Craig A. Coburn;Peter T. Meinke;Wei Chang;Christine M. Fandozzi

  • Structure−Activity Relationship of Heterobase-Modified 2‘-C-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

    Anne B Eldrup;Marija Prhavc;Jennifer Brooks;Balkrishen Bhat

  • Human Monoclonal Antibody HCV1 Effectively Prevents and Treats HCV Infection in Chimpanzees

    Trevor J. Morin;Teresa J. Broering;Brett A. Leav;Barbara M. Blair;Barbara M. Blair;Barbara M. Blair

  • Hcv ns3 protease inhibitors

    M. Katharine Holloway;Nigel J. Liverton;Steven W. Ludmerer;John A. Mccauley

  • Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

    John A. McCauley;Charles J. McIntyre;Michael T. Rudd;Kevin T. Nguyen

  • Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.

    Steven Harper;John A McCauley;Michael T Rudd;Marco Ferrara

  • Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid.

    Cathryn A. Shaw-Reid;Vandna Munshi;Pia Graham;Abigail Wolfe

  • SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development.

    Nicholas Murgolo;Alex G. Therien;Bonnie Howell;Daniel Klein

  • Recombinant microbial systems for the production of human collagen and gelatin.

    Julio Báez;David Olsen;James W. Polarek

  • Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay

    Steven W. Ludmerer;Donald J. Graham;Evelyn Boots;Edward M. Murray

  • Characterization of the Inhibition of Hepatitis C Virus RNA Replication by Nonnucleosides

    Licia Tomei;Sergio Altamura;Linda Bartholomew;Monica Bisbocci

  • Molecular modeling based approach to potent P2-P4 macrocyclic inhibitors of hepatitis C NS3/4A protease.

    Nigel J Liverton;M Katharine Holloway;John A McCauley;Michael T Rudd

Frequent Co-Authors

Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Joseph P. Vacca
Joseph P. Vacca MSD (United States)
Fritz Eckstein
Fritz Eckstein Max Planck Society
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Sheo B. Singh
Sheo B. Singh MSD (United States)
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
Ian W. Davies
Ian W. Davies Princeton University
Michael Rowley
Michael Rowley Pharmaron (United Kingdom)
Phillip Dan Cook
Phillip Dan Cook Ionis Pharmaceuticals (United States)
Kari I. Kivirikko
Kari I. Kivirikko University of Oulu

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