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Biology and Biochemistry

D-Index
80
Citations
21051
World Ranking
4129
National Ranking
2026

Overview

Celia A. Schiffer is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant focus on Molecular Biology, Infectious Diseases, Virology, Computational Theory and Mathematics, and Epidemiology.

The scientist's research topics cover a broad range within biomedical sciences and infectious diseases, including:

  • HIV/AIDS drug development and treatment
  • SARS-CoV-2 and COVID-19 research
  • HIV research and treatment
  • Computational drug discovery methods
  • RNA and protein synthesis mechanisms
  • Hepatitis C virus research
  • Monoclonal and polyclonal antibodies research

Among their recent papers are the following:

  • Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations, 2021, Immunity
  • A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction, 2020, Nature Communications
  • Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms, 2022, eLife
  • Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance, 2022, Nature Communications
  • Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188, 2021, Viruses

The frequent co-authors associated with Celia A. Schiffer's work include:

  • Neşe Kurt Yılmaz
  • Ala M. Shaqra
  • Akbar Ali
  • Qiu Yu J. Huang
  • G.J. Lockbaum

Publications are often found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nature Communications
  • Journal of Biological Chemistry
  • Viruses

Best Publications

  • Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B

    Mayer Rj;Davis Rb;Schiffer Ca;Berg Dt

  • Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes.

    Moses Prabu-Jeyabalan;Ellen A. Nalivaika;Celia A. Schiffer

  • Phase IB study of the FLT3 kinase inhibitor midostaurin with chemotherapy in younger newly diagnosed adult patients with acute myeloid leukemia

    R. M. Stone;T. Fischer;R. Paquette;G. Schiller

  • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes.

    Silverman Lr;Holland Jf;Weinberg Rs;Alter Bp

  • Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor.

    Dominique L. N. G. S Surleraux;Abdellah Tahri;Wim G. Verschueren;Geert M. E. Pille

  • Extramedullary leukemia adversely affects hematologic complete remission rate and overall survival in patients with t(8;21)(q22;q22): results from Cancer and Leukemia Group B 8461.

    J C Byrd;R B Weiss;D C Arthur;D Lawrence

  • Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

    Nancy M. King;Moses Prabu-Jeyabalan;Ellen A. Nalivaika;Piet B. T. P. Wigerinck

  • Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.

    Thomas D. Wu;Celia A. Schiffer;Matthew J. Gonzales;Jonathan Taylor

  • Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations.

    Frauke Muecksch;Yiska Weisblum;Christopher O. Barnes;Fabian Schmidt

  • Curling of Flap Tips in HIV-1 Protease as a Mechanism for Substrate Entry and Tolerance of Drug Resistance

    Walter Robert Peter Scott;Celia A. Schiffer

  • Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia

    A Neubauer;RK Dodge;SL George;FR Davey

  • The Molecular Basis of Drug Resistance against Hepatitis C Virus NS3/4A Protease Inhibitors.

    Keith P. Romano;Akbar Ali;Cihan Aydin;Djade Soumana

  • Use of surface marker analysis to predict outcome of adult acute myeloblastic leukemia

    JD Griffin;R Davis;DA Nelson;FR Davey

  • Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding.

    Keith P. Romano;Akbar Ali;William E. Royer;Celia A. Schiffer

  • How does a symmetric dimer recognize an asymmetric substrate? a substrate complex of HIV-1 protease

    Moses Prabu-Jeyabalan;Ellen A. Nalivaika;Celia A. Schiffer

  • A comparative study of two different doses of cytarabine for acute myeloid leukemia: a phase III trial of Cancer and Leukemia Group B.

    R O Dillman;R B Davis;M R Green;R B Weiss

  • Molecular Basis for Drug Resistance in HIV-1 Protease

    Akbar Ali;Rajintha M. Bandaranayake;Yufeng Cai;Nancy M. King

  • Combating susceptibility to drug resistance: lessons from HIV-1 protease.

    Nancy M. King;Moses Prabu-Jeyabalan;Ellen A. Nalivaika;Celia A. Schiffer

  • Viral protease inhibitors.

    Jeffrey Anderson;Celia A. Schiffer;Sook-Kyung Lee;Ronald I. Swanstrom

  • Methylcytosine and Normal Cytosine Deamination by the Foreign DNA Restriction Enzyme APOBEC3A

    Michael A. Carpenter;Ming Li;Anurag Rathore;Lela Lackey

Frequent Co-Authors

Tariq M. Rana
Tariq M. Rana University of California, San Diego
Ronald Swanstrom
Ronald Swanstrom University of North Carolina at Chapel Hill
Jeffrey D. Jensen
Jeffrey D. Jensen Arizona State University
Robert W. Finberg
Robert W. Finberg University of Massachusetts Chan Medical School
Michael K. Gilson
Michael K. Gilson University of California, San Diego
Robert J. Mayer
Robert J. Mayer Dana-Farber Cancer Institute
Timothy F. Kowalik
Timothy F. Kowalik University of Massachusetts Chan Medical School
Reuben S. Harris
Reuben S. Harris The University of Texas Health Science Center at San Antonio

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