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Medicine

D-Index
84
Citations
30136
World Ranking
14967
National Ranking
7563

Research.com Recognitions

  • 2022 - Foreign Member of the Polish Academy of Arts and Sciences

Overview

Krzysztof Mrózek is affiliated with The Ohio State University in the United States. Their research focuses primarily on hematology, molecular biology, and genetics, with a strong emphasis on acute myeloid leukemia (AML) and related blood cancers.

The scientist has contributed extensively to the field of Medicine through numerous publications, with particular expertise in subfields including:

  • Hematology
  • Molecular Biology
  • Genetics
  • Cancer Research
  • Public Health, Environmental and Occupational Health

Key topics of their work cover areas such as:

  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia Research
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Histone Deacetylase Inhibitors Research
  • Chronic Myeloid Leukemia Treatments
  • Cancer Genomics and Diagnostics
  • Protein Degradation and Inhibitors

Their recent papers illustrate ongoing contributions to the understanding of AML and associated genetic factors. Notable publications include:

  • Outcome prediction by the 2022 European LeukemiaNet genetic-risk classification for adults with acute myeloid leukemia: an Alliance study, 2023, Leukemia
  • Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/ KMT2A, 2020, Proceedings of the National Academy of Sciences
  • Additional gene mutations may refine the 2017 European LeukemiaNet classification in adult patients with de novo acute myeloid leukemia aged <60 years, 2020, Leukemia
  • Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia, 2020, Cancer Discovery
  • Combination of dasatinib with chemotherapy in previously untreated core binding factor acute myeloid leukemia: CALGB 10801, 2020, Blood Advances

The scientist has collaborated frequently with several co-authors, including:

  • Deedra Nicolet
  • Ann-Kathrin Eisfeld
  • Jonathan E. Kolitz
  • Bayard L. Powell
  • Richard M. Stone

Most of their work is published in specialized venues focused on hematologic malignancies and cancer biology, such as:

  • Blood
  • Blood Advances
  • Leukemia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Hematology & Oncology

Their research contributions encompass extensive investigation into the genetic and molecular mechanisms of leukemia, aiming to improve classification, prognosis, and treatment approaches for patients with these hematologic cancers.

Best Publications

  • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)

    John C. Byrd;Krzysztof Mrózek;Richard K. Dodge;Andrew J. Carroll

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

    Guido Marcucci;Kati Maharry;Yue-Zhong Wu;Michael D. Radmacher

  • Cytogenetics in acute leukemia

    Krzysztof Mrózek;Nyla A Heerema;Clara D Bloomfield

  • Absence of the Wild-Type Allele Predicts Poor Prognosis in Adult de Novo Acute Myeloid Leukemia with Normal Cytogenetics and the Internal Tandem Duplication of FLT3 A Cancer and Leukemia Group B Study

    Susan P. Whitman;Kellie J. Archer;Lan Feng;Claudia Baldus

  • Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study

    Peter Paschka;Guido Marcucci;Amy S. Ruppert;Krzysztof Mrózek

  • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?

    Krzysztof Mrózek;Guido Marcucci;Peter Paschka;Susan P. Whitman

  • MicroRNA expression in cytogenetically normal acute myeloid leukemia

    Guido Marcucci;Michael D. Radmacher;Michael D. Radmacher;Kati Maharry;Kati Maharry;Krzysztof Mrózek

  • Prognostic Significance of the European LeukemiaNet Standardized System for Reporting Cytogenetic and Molecular Alterations in Adults With Acute Myeloid Leukemia

    Krzysztof Mrózek;Guido Marcucci;Deedra Nicolet;Kati S. Maharry

  • PAX5 -driven subtypes of B-progenitor acute lymphoblastic leukemia

    Zhaohui Gu;Michelle L. Churchman;Kathryn G. Roberts;Ian Moore

  • Favorable Prognostic Impact of NPM1 Mutations in Older Patients With Cytogenetically Normal De Novo Acute Myeloid Leukemia and Associated Gene- and MicroRNA-Expression Signatures: A Cancer and Leukemia Group B Study

    Heiko Becker;Guido Marcucci;Kati Maharry;Michael D. Radmacher

  • Prognostic Factors and Outcome of Core Binding Factor Acute Myeloid Leukemia Patients With t(8;21) Differ From Those of Patients With inv(16): A Cancer and Leukemia Group B Study

    Guido Marcucci;Krzysztof Mrózek;Amy S. Ruppert;Kati Maharry

  • High Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.

    Kathryn G. Roberts;Zhaohui Gu;Debbie Payne-Turner;Kelly McCastlain

  • Prognostic Significance of, and Gene and MicroRNA Expression Signatures Associated With, CEBPA Mutations in Cytogenetically Normal Acute Myeloid Leukemia With High-Risk Molecular Features: A Cancer and Leukemia Group B Study

    Guido Marcucci;Kati Maharry;Michael D. Radmacher;Krzysztof Mrózek

  • TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study.

    Klaus H. Metzeler;Kati Maharry;Michael D. Radmacher;Krzysztof Mrózek

  • Prospective Karyotype Analysis in Adult Acute Lymphoblastic Leukemia: The Cancer and Leukemia Group B Experience

    Meir Wetzler;Richard K. Dodge;Krzysztof Mrózek;Andrew J. Carroll

  • A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403.

    Wendy Stock;Selina M. Luger;Anjali S. Advani;Jun Yin

  • Clinical significance of cytogenetics in acute myeloid leukemia

    K Mrózek;K Heinonen;A de la Chapelle;C D Bloomfield

  • FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

    Susan P. Whitman;Amy S. Ruppert;Amy S. Ruppert;Michael D. Radmacher;Michael D. Radmacher;Krzysztof Mrózek

  • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category

    Klaus H. Metzeler;Heiko Becker;Kati Maharry;Kati Maharry;Michael D. Radmacher;Michael D. Radmacher

Frequent Co-Authors

Clara D. Bloomfield
Clara D. Bloomfield The Ohio State University
Bayard L. Powell
Bayard L. Powell Wake Forest University
Andrew J. Carroll
Andrew J. Carroll University of Alabama at Birmingham
Jonathan E. Kolitz
Jonathan E. Kolitz Hofstra University
Richard A. Larson
Richard A. Larson University of Chicago
Guido Marcucci
Guido Marcucci City Of Hope National Medical Center
Richard Stone
Richard Stone Harvard University
Susan P. Whitman
Susan P. Whitman The Ohio State University
Michael A. Caligiuri
Michael A. Caligiuri City Of Hope National Medical Center
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute

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