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2025

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Overview

Frederick R. Appelbaum is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the field of Medicine, with a significant focus on Hematology, Public Health, Environmental and Occupational Health, Genetics, Oncology, and Molecular Biology.

The scientist's extensive publication record covers a range of topics centered around hematologic malignancies and related treatments. Notable research areas include:

  • Acute Myeloid Leukemia Research
  • Acute Lymphoblastic Leukemia Research
  • Hematopoietic Stem Cell Transplantation
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Neutropenia and Cancer Infections
  • Histone Deacetylase Inhibitors Research
  • Childhood Cancer Survivors' Quality of Life

Frederick R. Appelbaum has co-authored numerous papers with frequent collaborators, including:

  • Megan Othus
  • Harry P. Erba
  • Brenda M. Sandmaier
  • Roland B. Walter
  • Martin S. Tallman

These collaborations reflect ongoing research engagement in clinical and translational hematology.

Their research has been published in several prominent venues associated with hematology and oncology, with multiple papers appearing in:

  • Blood
  • Leukemia
  • Blood Advances
  • Transplantation and Cellular Therapy
  • Haematologica

Among the recent papers by Frederick R. Appelbaum, key publications include:

  • "Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN" (2022, Blood)
  • "NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021" (2021, Journal of the National Comprehensive Cancer Network)
  • "Survival, Nonrelapse Mortality, and Relapse-Related Mortality After Allogeneic Hematopoietic Cell Transplantation: Comparing 2003-2007 Versus 2013-2017 Cohorts" (2020, Annals of Internal Medicine)
  • "Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50-75 Years of Age With Advanced Myelodysplastic Syndrome" (2021, Journal of Clinical Oncology)
  • "Midostaurin reduces relapse in FLT3-mutant acute myeloid leukemia: the Alliance CALGB 10603/RATIFY trial" (2021, Leukemia)

Best Publications

  • Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

    Hartmut Döhner;Elihu Estey;David Grimwade;Sergio Amadori

  • Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.

    Hartmut Dohner;Elihu H. Estey;Sergio Amadori;Frederick R. Appelbaum

  • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group study

    Marilyn L. Slovak;Kenneth J. Kopecky;Peter A. Cassileth;David H. Harrington

  • Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

    Richard M. Stone;Sumithra J. Mandrekar;Ben L. Sanford;Kristina Laumann

  • Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

    Michele Baccarani;Giuseppe Saglio;John Goldman;Andreas Hochhaus

  • Reduced mortality after allogeneic hematopoietic-cell transplantation.

    Ted A. Gooley;Jason W. Chien;Jason W. Chien;Steven A. Pergam;Steven A. Pergam;Sangeeta Hingorani;Sangeeta Hingorani

  • Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

    Peter A. McSweeney;Peter A. McSweeney;Peter A. McSweeney;Dietger Niederwieser;Dietger Niederwieser;Dietger Niederwieser;Judith A. Shizuru;Judith A. Shizuru;Judith A. Shizuru;Brenda M. Sandmaier;Brenda M. Sandmaier;Brenda M. Sandmaier

  • Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

    Rainer Storb;H. Joachim Deeg;John Whitehead;Frederick Appelbaum

  • Age and acute myeloid leukemia

    Frederick R Appelbaum;Holly M Gundacker;David R Head;Marilyn L Slovak

  • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia

    Kanti R. Rai;Bercedis L. Peterson;Frederick R. Appelbaum;Jonathan Kolitz

  • All-trans-Retinoic Acid in Acute Promyelocytic Leukemia

    Martin S. Tallman;Janet W. Andersen;Charles A. Schiffer;Frederick R. Appelbaum

  • Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group Study

    Catherine P. Leith;Kenneth J. Kopecky;John Godwin;Thomas McConnell

  • Efficacy and Safety of Gemtuzumab Ozogamicin in Patients With CD33-Positive Acute Myeloid Leukemia in First Relapse

    Eric L. Sievers;Richard A. Larson;Edward A. Stadtmauer;Elihu Estey

  • Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers

    William I. Bensinger;Paul J. Martin;Barry Storer;Reginald Clift

  • Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.

    John Koreth;Richard Schlenk;Kenneth J. Kopecky;Sumihisa Honda

  • Regimen-related toxicity in patients undergoing bone marrow transplantation.

    S I Bearman;F R Appelbaum;C D Buckner;F B Petersen

  • Chronic graft-versus-host disease and other late complications of bone marrow transplantation.

    K M Sullivan;E Agura;C Anasetti;F Appelbaum

  • Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

    Catherine P. Leith;Kenneth J. Kopecky;I-Ming Chen;Lisette Eijdems

  • Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma.

    C Anasetti;D Amos;P G Beatty;F R Appelbaum

  • Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor

    WI Bensinger;CH Weaver;FR Appelbaum;S Rowley

Frequent Co-Authors

Rainer Storb
Rainer Storb Fred Hutchinson Cancer Research Center
Elihu H. Estey
Elihu H. Estey University of Washington
H. Joachim Deeg
H. Joachim Deeg Fred Hutchinson Cancer Research Center
Brenda M. Sandmaier
Brenda M. Sandmaier Fred Hutchinson Cancer Research Center
Ted Gooley
Ted Gooley Fred Hutchinson Cancer Research Center
Barry E. Storer
Barry E. Storer Fred Hutchinson Cancer Research Center
Paul J. Martin
Paul J. Martin Fred Hutchinson Cancer Research Center
Jerald P. Radich
Jerald P. Radich Fred Hutchinson Cancer Research Center
Cheryl L. Willman
Cheryl L. Willman University of New Mexico
Richard A. Larson
Richard A. Larson University of Chicago

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