World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
122
Citations
70391
World Ranking
574
National Ranking
364

Medicine

D-Index
125
Citations
72582
World Ranking
3040
National Ranking
1678

Research.com Recognitions

  • 2015 - Fellow of the Australian Academy of Health and Medical Science
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Charles G. Mullighan is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily focuses on the intersection of medicine, biochemistry, genetics, and molecular biology, with significant contributions in the fields of public health, environmental and occupational health, molecular biology, hematology, genetics, and oncology.

The scientist has explored major topics including acute lymphoblastic leukemia research, acute myeloid leukemia research, chronic myeloid leukemia treatments, cancer genomics and diagnostics, childhood cancer survivors' quality of life, CAR-T cell therapy research, and chronic lymphocytic leukemia research.

Frequent co-authors in their work include Kathryn G. Roberts, Ilaria Iacobucci, Jun J. Yang, Mignon L. Loh, and Ching-Hon Pui.

Charles G. Mullighan has published extensively in several venues, most notably:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Lymphoma Myeloma & Leukemia
  • Leukemia
  • Cancer Research

Recent notable papers include:

  • International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data, 2022, Blood
  • Pediatric acute lymphoblastic leukemia, 2020, Haematologica
  • The genomic landscape of pediatric acute lymphoblastic leukemia, 2022, Nature Genetics
  • Venetoclax and Navitoclax in Combination with Chemotherapy in Patients with Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma, 2021, Cancer Discovery
  • St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem, 2021, Cancer Discovery

The researcher has been recognized with awards such as Fellow of the Australian Academy of Health and Medical Science in 2015 and membership in the Association of American Physicians.

Best Publications

  • Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

    Charles G. Mullighan;Salil Goorha;Ina Radtke;Christopher B. Miller

  • Acute Lymphoblastic Leukemia in Children

    Stephen P. Hunger;Charles G. Mullighan

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

    Gang Wu;Alberto Broniscer;Troy A McEachron;Charles Lu

  • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.

    Charles G Mullighan;Xiaoping Su;Jinghui Zhang;Ina Radtke

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Acute lymphoblastic leukaemia.

    Hiroto Inaba;Mel Greaves;Charles G Mullighan

  • BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

    Charles G. Mullighan;Christopher B. Miller;Ina Radtke;Letha A. Phillips

  • Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

    Elaine Coustan-Smith;Charles G. Mullighan;Mihaela Onciu;Frederick G. Behm

  • Analysis of the coding genome of diffuse large B-cell lymphoma

    Laura Pasqualucci;Vladimir Trifonov;Giulia Fabbri;Jing Ma

  • Inactivating mutations of acetyltransferase genes in B-cell lymphoma

    Laura Pasqualucci;David Dominguez-Sola;Annalisa Chiarenza;Giulia Fabbri

  • Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

    Ching Hon Pui;Jun J. Yang;Stephen P. Hunger;Rob Pieters

  • The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia

    Yu Liu;John Easton;Ying Shao;Jamie Maciaszek

  • Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

    Charles G. Mullighan;Letha A. Phillips;Xiaoping Su;Jing Ma

  • Lin28 promotes transformation and is associated with advanced human malignancies

    Srinivas R Viswanathan;John T Powers;William Einhorn;Yujin Hoshida

  • Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

    Kathryn G. Roberts;Ryan D. Morin;Jinghui Zhang;Martin Hirst

  • Variable Clonal Repopulation Dynamics Influence Chemotherapy Response in Colorectal Cancer

    Antonija Kreso;Antonija Kreso;Catherine A. O'Brien;Catherine A. O'Brien;Peter van Galen;Olga I. Gan

  • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

    Jinghui Zhang;Gang Wu;Claudia P. Miller;Ruth G. Tatevossian

  • Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

    Giulia Fabbri;Silvia Rasi;Davide Rossi;Vladimir A. Trifonov

  • The genomic landscape of hypodiploid acute lymphoblastic leukemia

    Linda Holmfeldt;Lei Wei;Ernesto Diaz-Flores;Michael Walsh

Frequent Co-Authors

Stephen P. Hunger
Stephen P. Hunger University of Pennsylvania
James R. Downing
James R. Downing St. Jude Children's Research Hospital
Mignon L. Loh
Mignon L. Loh University of California, San Francisco
Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Meenakshi Devidas
Meenakshi Devidas St. Jude Children's Research Hospital
Cheryl L. Willman
Cheryl L. Willman University of New Mexico
Julie M. Gastier-Foster
Julie M. Gastier-Foster Baylor College of Medicine
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital
William L. Carroll
William L. Carroll New York University

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