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Medicine

D-Index
142
Citations
117675
World Ranking
1532
National Ranking
890

Research.com Recognitions

  • 2016 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

James R. Downing is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily spans several interconnected fields within biomedical science, including Medicine and Biochemistry, Genetics and Molecular Biology. The subfields most frequently associated with their work include Molecular Biology, Pediatrics, Perinatology and Child Health, Public Health, Environmental and Occupational Health, Cancer Research, and Hematology.

Downing's scientific contributions encompass a range of topics with a focus on leukemia and childhood cancers. Key research topics include:

  • Acute Lymphoblastic Leukemia research
  • Acute Myeloid Leukemia Research
  • Childhood Cancer Survivors' Quality of Life
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Neuroblastoma Research and Treatments
  • Lung Cancer Research Studies

Among the recent papers authored or co-authored by Downing are:

  • The genomic landscape of pediatric acute lymphoblastic leukemia, published in 2022 in Nature Genetics
  • St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem, published in 2021 in Cancer Discovery
  • Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations, published in 2020 in Nature Communications
  • Clinical Significance of Novel Subtypes of Acute Lymphoblastic Leukemia in the Context of Minimal Residual Disease-Directed Therapy, published in 2021 in Blood Cancer Discovery
  • MYCN amplification and ATRX mutations are incompatible in neuroblastoma, published in 2020 in Nature Communications

Frequent co-authors who have collaborated with Downing include:

  • Jinghui Zhang
  • Charles G. Mullighan
  • Michael Rusch
  • John Easton
  • Yu Liu

The venues where Downing has regularly published research work include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Blood Cancer Discovery
  • Cancer Research
  • Nature Communications
  • Leukemia

Over the course of their career, Downing has received recognition in the form of awards such as the Fellow of the American Academy of Arts and Sciences in 2016 and Fellow of the American Association for the Advancement of Science (AAAS) in 2003.

Best Publications

  • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.

    T. R. Golub;T. R. Golub;D. K. Slonim;P. Tamayo;C. Huard

  • MicroRNA expression profiles classify human cancers

    Jun Lu;Gad Getz;Eric A. Miska;Eric A. Miska;Ezequiel Alvarez-Saavedra

  • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

    Timothy J. Ley;Christopher Miller;Li Ding;Benjamin J. Raphael

  • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.

    Eng Juh Yeoh;Mary E. Ross;Sheila A. Shurtleff;W. Kent Williams

  • AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

    Tsukasa Okuda;Jan van Deursen;Scott W Hiebert;Gerard Grosveld

  • Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

    Charles G. Mullighan;Salil Goorha;Ina Radtke;Christopher B. Miller

  • Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis.

    Jacob H. Levine;Erin F. Simonds;Sean C. Bendall;Kara L. Davis

  • Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF

    Takehiko Kamijo;Frederique Zindy;Martine F. Roussel;Dawn E. Quelle

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

    Gang Wu;Alberto Broniscer;Troy A McEachron;Charles Lu

  • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia.

    Charles G Mullighan;Xiaoping Su;Jinghui Zhang;Ina Radtke

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Treating childhood acute lymphoblastic leukemia without cranial irradiation.

    Ching Hon Pui;Dario Campana;Deqing Pei;W. Paul Bowman

  • Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia

    Adolfo A Ferrando;Donna S Neuberg;Jane Staunton;Mignon L Loh

  • Germline Mutations in Predisposition Genes in Pediatric Cancer

    Jinghui Zhang;Michael F. Walsh;Gang Wu;Michael N. Edmonson

  • BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

    Charles G. Mullighan;Christopher B. Miller;Ina Radtke;Letha A. Phillips

  • Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

    Elaine Coustan-Smith;Charles G. Mullighan;Mihaela Onciu;Frederick G. Behm

  • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

    Gang Wu;Alexander K Diaz;Alexander K Diaz;Barbara S Paugh;Sherri L Rankin

  • Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

    Ching Hon Pui;Jun J. Yang;Stephen P. Hunger;Rob Pieters

  • Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

    Charles G. Mullighan;Letha A. Phillips;Xiaoping Su;Jing Ma

Frequent Co-Authors

Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Sheila A. Shurtleff
Sheila A. Shurtleff St. Jude Children's Research Hospital
John Easton
John Easton St. Jude Children's Research Hospital
Susana C. Raimondi
Susana C. Raimondi St. Jude Children's Research Hospital
Michael Rusch
Michael Rusch St. Jude Children's Research Hospital
Jeffrey E. Rubnitz
Jeffrey E. Rubnitz St. Jude Children's Research Hospital
Gang Wu
Gang Wu Washington University in St. Louis
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital

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