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Medicine

D-Index
147
Citations
85269
World Ranking
1274
National Ranking
740

Overview

William E. Evans is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily focuses on pediatric acute lymphoblastic leukemia (ALL) and related hematologic malignancies, with significant contributions in cancer genomics and diagnostics, cancer therapeutics, and mechanisms underlying leukemia.

The main fields of study for Evans include Medicine and Biochemistry, Genetics, and Molecular Biology. Subfields of particular emphasis encompass Public Health, Environmental and Occupational Health, Molecular Biology, Pediatrics, Perinatology and Child Health, Hematology, and Oncology.

Evans has contributed extensively to research on topics such as:

  • Acute Lymphoblastic Leukemia research
  • Childhood Cancer Survivors' Quality of Life
  • Acute Myeloid Leukemia Research
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Cancer therapeutics and mechanisms
  • Chronic Myeloid Leukemia Treatments

Notable recent publications authored or co-authored by Evans include:

  • The genomic landscape of pediatric acute lymphoblastic leukemia, 2022, Nature Genetics
  • Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia, 2021, Cancer Discovery
  • Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia, 2021, Nature Cancer
  • Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia, 2020, Blood Cancer Discovery
  • Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response, 2023, Nature Medicine

Frequent co-authors include:

  • Ching-Hon Pui
  • Jun J. Yang
  • Wenjian Yang
  • Mary V. Relling
  • Charles G. Mullighan

Evans has published in a variety of venues, predominantly those specializing in hematology and cancer research. These include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Leukemia
  • Clinical Lymphoma Myeloma & Leukemia
  • Nature Communications

Best Publications

  • Pharmacogenomics: Translating Functional Genomics into Rational Therapeutics

    William E. Evans;Mary V. Relling

  • Treatment of acute lymphoblastic leukemia.

    Ching-Hon Pui;William E Evans

  • Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

    William E Evans;Howard L McLeod

  • Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.

    Eng Juh Yeoh;Mary E. Ross;Sheila A. Shurtleff;W. Kent Williams

  • Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

    Charles G. Mullighan;Salil Goorha;Ina Radtke;Christopher B. Miller

  • The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

    Jinghui Zhang;Li Ding;Linda Holmfeldt;Gang Wu

  • Targetable Kinase-Activating Lesions in Ph-like Acute Lymphoblastic Leukemia

    K. G. Roberts;Y. Li;D. Payne-Turner;R. C. Harvey

  • Treating childhood acute lymphoblastic leukemia without cranial irradiation.

    Ching Hon Pui;Dario Campana;Deqing Pei;W. Paul Bowman

  • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study

    Monique L Den Boer;Marjon van Slegtenhorst;Renée X De Menezes;Renée X De Menezes;Meyling H Cheok

  • Molecular diagnosis of thiopurine S-methyltransferase deficiency: Genetic basis for azathioprine and mercaptopurine intolerance

    Charles R. Yates;Eugene Y. Krynetski;Thrina Loennechen;Michael Y. Fessing

  • Moving towards individualized medicine with pharmacogenomics

    William E. Evans;Mary V. Relling;Mary V. Relling

  • Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

    Ching Hon Pui;Jun J. Yang;Stephen P. Hunger;Rob Pieters

  • Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus

    Mary V. Relling;Michael L. Hancock;Gaston K. Rivera;John T. Sandlund

  • Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

    Kathryn G. Roberts;Ryan D. Morin;Jinghui Zhang;Martin Hirst

  • Pharmacogenomics in the clinic

    Mary V. Relling;William E. Evans

  • Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing.

    Relling Mv;Gardner Ee;Sandborn Wj;Schmiegelow K

  • Acute myeloid leukemia in children treated with epipodophyllotoxins for acute lymphoblastic leukemia.

    C H Pui;R C Ribeiro;M L Hancock;G K Rivera

  • Pharmacogenomics and Individualized Drug Therapy

    Michel Eichelbaum;Magnus Ingelman-Sundberg;William E. Evans

  • Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing: 2013 Update

    M V Relling;E E Gardner;W J Sandborn;K Schmiegelow

  • Gene-Expression Patterns in Drug-Resistant Acute Lymphoblastic Leukemia Cells and Response to Treatment

    Amy Holleman;Meyling H Cheok;Monique L den Boer;Wenjian Yang

Frequent Co-Authors

Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital
Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
John T. Sandlund
John T. Sandlund National Institutes of Health
Raul C. Ribeiro
Raul C. Ribeiro St. Jude Children's Research Hospital
Jun J. Yang
Jun J. Yang St. Jude Children's Research Hospital
Stephen P. Hunger
Stephen P. Hunger University of Pennsylvania
Gaston K. Rivera
Gaston K. Rivera St. Jude Children's Research Hospital
William L. Carroll
William L. Carroll New York University
Meenakshi Devidas
Meenakshi Devidas St. Jude Children's Research Hospital
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital

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