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Genetics

D-Index
76
Citations
21155
World Ranking
1828
National Ranking
841

Overview

Jun J. Yang is affiliated with St. Jude Children's Research Hospital in the United States. Their primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in subfields such as Public Health, Environmental and Occupational Health, Molecular Biology, Pediatrics, Perinatology and Child Health, Hematology, and Oncology. The main topics addressed in their research reflect a focus on cancer and hematological disorders, particularly pediatric conditions.

Their research portfolio includes extensive work on Acute Lymphoblastic Leukemia (ALL), with additional attention given to Acute Myeloid Leukemia, childhood cancer survivors' quality of life, epigenetics and DNA methylation, chronic myeloid leukemia treatments, CAR-T cell therapy, and the function and interaction of immune cells.

Frequent coauthors in their publications include:

  • Ching-Hon Pui
  • Wenjian Yang
  • Charles G. Mullighan
  • Mary V. Relling
  • William E. Evans

Their published work frequently appears in notable journals and platforms, with the highest number of publications in Blood, followed by bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Leukemia, and Cancer Research.

Some of their recent papers include:

  • "Cancer health disparities in racial/ethnic minorities in the United States" (2020, British Journal of Cancer)
  • "The genomic landscape of pediatric acute lymphoblastic leukemia" (2022, Nature Genetics)
  • "Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction" (2020, Nature Metabolism)
  • "Effect of Dasatinib vs Imatinib in the Treatment of Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia" (2020, JAMA Oncology)
  • "Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage-Ambiguous Stem Cell Leukemia" (2021, Cancer Discovery)

The range of their research contributions spans genomics, molecular mechanisms of leukemia, cancer treatment comparisons, metabolic influences on immune cells, and genetic regulation impacting cancer development. This multidisciplinary approach aligns with their involvement across both public health and molecular biology domains, emphasizing pediatric and hematologic oncology.

Best Publications

  • Cancer health disparities in racial/ethnic minorities in the United States

    Valentina A Zavala;Paige M Bracci;John M Carethers;Luis Carvajal-Carmona

  • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.

    Richard C. Harvey;Richard C. Harvey;Charles G. Mullighan;Xuefei Wang;Kevin K. Dobbin

  • PAX5 -driven subtypes of B-progenitor acute lymphoblastic leukemia

    Zhaohui Gu;Michelle L. Churchman;Kathryn G. Roberts;Ian Moore

  • Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP

    Shangxi Xiao;Shangxi Xiao;Chuan Yu;Xueming Chou;Wenjuan Yuan

  • Evaluation of disulfide reduction during receptor-mediated endocytosis by using FRET imaging.

    Jun Yang;Hongtao Chen;Iontcho R. Vlahov;Ji Xin Cheng

  • Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

    Virginia Perez-Andreu;Kathryn G. Roberts;Richard C. Harvey;Wenjian Yang

  • A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

    Sohela Shah;Kasmintan A. Schrader;Esmé Waanders;Andrew E. Timms

  • Deregulation of DUX4 and ERG in acute lymphoblastic leukemia

    Jinghui Zhang;Kelly McCastlain;Hiroki Yoshihara;Beisi Xu

  • Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia.

    Yuan-Fang Liu;Bai-Yan Wang;Bai-Yan Wang;Wei-Na Zhang;Jin-Yan Huang

  • Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.

    Julia A Meyer;Jinhua Wang;Laura E. Hogan;Laura E. Hogan;Jun J Yang

  • Inosine is an alternative carbon source for CD8+-T-cell function under glucose restriction

    Tingting Wang;J. N. Rashida Gnanaprakasam;Xuyong Chen;Siwen Kang

  • Biology of childhood acute lymphoblastic leukemia.

    Deepa Bhojwani;Jun J. Yang;Ching-Hon Pui

  • Novel Susceptibility Variants at 10p12.31-12.2 for Childhood Acute Lymphoblastic Leukemia in Ethnically Diverse Populations

    Heng Xu;Wenjian Yang;Virginia Perez-Andreu;Meenakshi Devidas

  • Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

    Jun J. Yang;Cheng Cheng;Wenjian Yang;Deqing Pei

  • Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies

    Laura E. Hogan;Julia A. Meyer;Jun Yang;Jinhua Wang

  • Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases

    Jian Feng Li;Yu Ting Dai;Henrik Lilljebjörn;Shu Hong Shen

  • ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia

    Heng Xu;Cheng Cheng;Meenakshi Devidas;Deqing Pei

  • Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

    Benshang Li;Samuel W. Brady;Xiaotu Ma;Shuhong Shen

  • Germline genetic variation in ETV6 and risk of childhood acute lymphoblastic leukaemia: a systematic genetic study

    Takaya Moriyama;Monika L. Metzger;Gang Wu;Rina Nishii

  • Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents

    Sumith A. Kularatne;Zhigang Zhou;Jun Yang;Carol B. Post

Frequent Co-Authors

Ching-Hon Pui
Ching-Hon Pui St. Jude Children's Research Hospital
Mary V. Relling
Mary V. Relling St. Jude Children's Research Hospital
William E. Evans
William E. Evans St. Jude Children's Research Hospital
Stephen P. Hunger
Stephen P. Hunger University of Pennsylvania
Charles G. Mullighan
Charles G. Mullighan St. Jude Children's Research Hospital
Mignon L. Loh
Mignon L. Loh University of California, San Francisco
William L. Carroll
William L. Carroll New York University
Meenakshi Devidas
Meenakshi Devidas St. Jude Children's Research Hospital
Jinghui Zhang
Jinghui Zhang St. Jude Children's Research Hospital
Naomi J. Winick
Naomi J. Winick The University of Texas Southwestern Medical Center

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