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Medicine

D-Index
122
Citations
56047
World Ranking
3471
National Ranking
1907

Overview

Howard L. McLeod is affiliated with Utah Tech University in the United States. Their research contributions span multiple domains within medicine, with a particular focus on oncology and molecular biology. Their work includes an emphasis on pharmacogenetics and drug metabolism, colorectal cancer treatments and studies, cancer genomics and diagnostics, as well as cancer immunotherapy and biomarkers.

McLeod's active research topics also include lung cancer treatments and mutations, cancer therapeutics and mechanisms, and the intersection of cancer, stress, anesthesia, and immune response.

Frequent coauthors collaborating with McLeod include Mark J. Ratain, Alison A. Motsinger-Reif, Yijing He, Tammy M. Havener, and Kouros Owzar.

McLeod has published extensively in several academic venues, with the highest number of contributions appearing in UNC Libraries. Other common publication venues are the Journal of Clinical Oncology, bioRxiv (Cold Spring Harbor Laboratory), Clinical Pharmacology & Therapeutics, and the British Journal of Cancer.

Among McLeod's recent papers are:

  • PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer (2022, Cancer Letters)
  • Expanded Clinical Pharmacogenetics Implementation Consortium Guideline for Medication Use in the Context of G6PD Genotype (2022, Clinical Pharmacology & Therapeutics)
  • UGT1A1 genotype-guided dosing of irinotecan: A prospective safety and cost analysis in poor metaboliser patients (2022, European Journal of Cancer)
  • Propranolol Suppresses the Growth of Colorectal Cancer Through Simultaneously Activating Autologous CD8+ T Cells and Inhibiting Tumor AKT/MAPK Pathway (2020, Clinical Pharmacology & Therapeutics)
  • Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy (2020, Clinical Pharmacology & Therapeutics)

Best Publications

  • Pharmacogenomics — Drug Disposition, Drug Targets, and Side Effects

    William E Evans;Howard L McLeod

  • Doxorubicin pathways: pharmacodynamics and adverse effects

    Caroline F. Thorn;Connie Oshiro;Sharon Marsh;Tina Hernandez-Boussard

  • Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose.

    Mark J. Rieder;Alexander P. Reiner;Brian F. Gage;Deborah A. Nickerson

  • Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin

    BF Gage;C Eby;JA Johnson;E Deych

  • Genomics and Drug Response

    Liewei Wang;Howard L. McLeod;Richard M. Weinshilboum

  • Platinum neurotoxicity pharmacogenetics

    Sarah R. McWhinney;Richard M. Goldberg;Howard L. McLeod

  • MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.

    Margaret-Mary Ameyaw;Fernando Regateiro;Tao Li;Xiehe Liu

  • Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

    Shufeng Zhou;Sui Yung Chan;Boon Cher Goh;Eli Chan

  • Gene Expression Profiles and Molecular Markers To Predict Recurrence of Dukes' B Colon Cancer

    Yixin Wang;Tim Jatkoe;Yi Zhang;Matthew G. Mutch

  • UGT1A1*28 Genotype and Irinotecan-Induced Neutropenia: Dose Matters

    Janelle M. Hoskins;Richard M. Goldberg;Pingping Qu;Joseph G. Ibrahim

  • PI3K/Akt/mTOR pathway as a target for cancer therapy.

    Daniel Morgensztern;Howard L McLeod

  • Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia.

    H L McLeod;E Y Krynetski;M V Relling;W E Evans

  • Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update

    Ursula Amstutz;Linda M. Henricks;Steven M. Offer;Julia Barbarino

  • Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism

    G.J Peters;H.H.J Backus;S Freemantle;B van Triest

  • Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine

    Alison J. Black;Howard L. McLeod;Hillary A. Capell;Robert H. Powrie

  • Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

    Xiaoxiong Wei;Howard L. McLeod;Julieann McMurrough;Frank J. Gonzalez

  • Carbamazepine, HLA-B*1502 and risk of Stevens–Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations

    P Brent Ferrell;Howard L McLeod

  • The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1 and Simvastatin‐Induced Myopathy: 2014 Update

    L B Ramsey;S G Johnson;S G Johnson;K E Caudle;C E Haidar

  • The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.

    E. S. R. Collie-Duguid;S. C. Pritchard;R. H. Powrie;J. Sludden

  • A genome-based model for adjusting radiotherapy dose (GARD): a retrospective, cohort-based study

    Jacob G Scott;Anders Berglund;Michael J Schell;Ivaylo Mihaylov

Frequent Co-Authors

Mark J. Ratain
Mark J. Ratain University of Chicago
Graeme I. Murray
Graeme I. Murray University of Aberdeen
Jim Cassidy
Jim Cassidy University of Glasgow
Teri E. Klein
Teri E. Klein Stanford University
Lisa A. Carey
Lisa A. Carey University of North Carolina at Chapel Hill
Richard M. Goldberg
Richard M. Goldberg West Virginia University
Tsuyoshi Yokoi
Tsuyoshi Yokoi Nagoya University
John A. Spertus
John A. Spertus University of Missouri–Kansas City
David A. Flockhart
David A. Flockhart Indiana University

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