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Medicine

D-Index
126
Citations
84706
World Ranking
2883
National Ranking
1601

Overview

Heinz-Josef Lenz is affiliated with the University of Southern California in the United States. Their research is concentrated in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Lenz's work spans several subfields, including Oncology, Cancer Research, Pathology and Forensic Medicine, Molecular Biology, and Pulmonary and Respiratory Medicine.

The scientist's primary research topics include colorectal cancer treatments and studies, genetic factors in colorectal cancer, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, gastric cancer management and outcomes, lung cancer treatments and mutations, and pancreatic and hepatic oncology research.

Lenz's body of work features publications in prominent venues, with the most frequent being the Journal of Clinical Oncology, followed by Annals of Oncology, Cancer Research, Clinical Cancer Research, and Oncogene.

Frequent collaborators in Lenz's research include Francesca Battaglin, Shivani Soni, Joanne Xiu, Richard M. Goldberg, and John L. Marshall.

Among the scientist's recent academic papers are:

  • Randomized Trial of Irinotecan and Cetuximab With or Without Vemurafenib in BRAF-Mutant Metastatic Colorectal Cancer (SWOG S1406), 2020, Journal of Clinical Oncology
  • ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal-Anal Task Forces whitepaper, 2020, Nature Reviews Clinical Oncology
  • Tucatinib plus trastuzumab for chemotherapy-refractory, HER2-positive, RAS wild-type unresectable or metastatic colorectal cancer (MOUNTAINEER): a multicentre, open-label, phase 2 study, 2023, The Lancet Oncology
  • Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle, 2023, Proceedings of the National Academy of Sciences
  • Nivolumab plus Ipilimumab in Microsatellite-Instability-High Metastatic Colorectal Cancer, 2024, New England Journal of Medicine

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

    Axel Grothey;Eric Van Cutsem;Alberto Sobrero;Salvatore Siena

  • Nivolumab in patients with metastatic DNA mismatch repair-deficient or microsatellite instability-high colorectal cancer (CheckMate 142): an open-label, multicentre, phase 2 study

    Michael J. Overman;Ray McDermott;Joseph L. Leach;Sara Lonardi

  • Durable clinical benefit with nivolumab plus ipilimumab in DNA mismatch repair-deficient/microsatellite instability-high metastatic colorectal cancer

    Michael J. Overman;Sara Lonardi;Ka Yeung Mark Wong;Heinz Josef Lenz

  • Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer

    Robert J Mayer;Eric Van Cutsem;Alfredo Falcone;Takayuki Yoshino

  • EPIC: Phase III Trial of Cetuximab Plus Irinotecan After Fluoropyrimidine and Oxaliplatin Failure in Patients With Metastatic Colorectal Cancer

    Alberto F. Sobrero;Joan Maurel;Louis Fehrenbacher;Werner Scheithauer

  • Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase

    Dennis Salonga;Kathleen D. Danenberg;Martin Johnson;Ralf Metzger

  • CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation - A target for novel cancer therapy.

    Ryuma Tokunaga;Wu Zhang;Madiha Naseem;Alberto Puccini

  • Thymidylate Synthase Gene and Protein Expression Correlate and Are Associated with Response to 5-Fluorouracil in Human Colorectal and Gastric Tumors

    Patrick G. Johnston;Heinz-Josef Lenz;Cynthia G. Leichman;Kathleen D. Danenberg

  • Effect of First-Line Chemotherapy Combined With Cetuximab or Bevacizumab on Overall Survival in Patients With KRAS Wild-Type Advanced or Metastatic Colorectal Cancer: A Randomized Clinical Trial

    Alan P. Venook;Donna Niedzwiecki;Heinz Josef Lenz;Federico Innocenti

  • Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer

    Eric Van Cutsem;Heinz Josef Lenz;Claus Henning Köhne;Volker Heinemann

  • ERCC1 and Thymidylate Synthase mRNA Levels Predict Survival for Colorectal Cancer Patients Receiving Combination Oxaliplatin and Fluorouracil Chemotherapy

    Yoshinori Shirota;Jan Stoehlmacher;Jan Brabender;Yi-Ping Xiong

  • The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.

    Mark M. Pomerantz;Nasim Ahmadiyeh;Nasim Ahmadiyeh;Li Jia;Paula Herman

  • Phase II Clinical Trial of Bevacizumab and Low-Dose Metronomic Oral Cyclophosphamide in Recurrent Ovarian Cancer: A Trial of the California, Chicago, and Princess Margaret Hospital Phase II Consortia

    Agustin A. Garcia;Hal Hirte;Gini Fleming;Dongyun Yang

  • Activity of Sunitinib in Patients With Advanced Neuroendocrine Tumors

    Matthew H. Kulke;Heinz Josef Lenz;Neal J. Meropol;James Posey

  • Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer Retrospective Analyses of the CRYSTAL and FIRE-3 Trials

    Sabine Tejpar;Sebastian Stintzing;Fortunato Ciardiello;Josep Tabernero

  • Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy.

    Sheeja T. Pullarkat;Jan Stoehlmacher;V. Ghaderi;Yi Ping Xiong

  • ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy.

    Ralf Metzger;Cynthia Gail Leichman;Kathleen D. Danenberg;Peter V. Danenberg

  • Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin.

    Cynthia Gail Leichman;Heinz-Josef Lenz;Lawrence Leichman;Kathleen Danenberg

  • FCGR2A and FCGR3A Polymorphisms Associated With Clinical Outcome of Epidermal Growth Factor Receptor–Expressing Metastatic Colorectal Cancer Patients Treated With Single-Agent Cetuximab

    Wu Zhang;Michael Gordon;Anne M. Schultheis;Dong Yun Yang

Frequent Co-Authors

Fotios Loupakis
Fotios Loupakis Istituto Oncologico Veneto
Alfredo Falcone
Alfredo Falcone University of Pisa
Volker Heinemann
Volker Heinemann Ludwig-Maximilians-Universität München
Richard M. Goldberg
Richard M. Goldberg West Virginia University
Axel Grothey
Axel Grothey University of Tennessee at Knoxville
Philip A. Philip
Philip A. Philip Wayne State University
Howard S. Hochster
Howard S. Hochster Yale University
David R. Gandara
David R. Gandara University of California, Davis
Susan Groshen
Susan Groshen University of Southern California

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