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Alfredo Falcone

Alfredo Falcone

D-Index & Metrics

Medicine

D-Index
95
Citations
45015
World Ranking
9897
National Ranking
349

Overview

Alfredo Falcone is affiliated with the University of Pisa in Italy, specializing in medical research with a focus on oncology. Their work encompasses a broad range of studies on cancer treatment and related fields.

Falcone's research primarily focuses on the following topics:

  • Colorectal Cancer Treatments and Studies
  • Genetic factors in colorectal cancer
  • Cancer Genomics and Diagnostics
  • Cancer Treatment and Pharmacology
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Gastric Cancer Management and Outcomes
  • Cancer Immunotherapy and Biomarkers

Their contributions span across several subfields of study within medicine, including:

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research
  • Pathology and Forensic Medicine
  • Hepatology

Alfredo Falcone has co-authored extensively with several researchers, indicating collaborative work within the oncology community. Frequent coauthors include:

  • Chiara Cremolini
  • Daniele Rossini
  • Heinz-Josef Lenz
  • Carlotta Antoniotti
  • Gianluca Masi

The primary venues for Falcone's research publications are journals focused on clinical oncology and cancer research, which include:

  • Journal of Clinical Oncology
  • Annals of Oncology
  • European Journal of Cancer
  • Cancers
  • ESMO Open

Some of the recent publications authored or coauthored by Alfredo Falcone are:

  • Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial, 2023, The Lancet
  • Upfront FOLFOXIRI plus bevacizumab and reintroduction after progression versus mFOLFOX6 plus bevacizumab followed by FOLFIRI plus bevacizumab in the treatment of patients with metastatic colorectal cancer (TRIBE2): a multicentre, open-label, phase 3, randomised, controlled trial, 2020, The Lancet Oncology
  • Individual Patient Data Meta-Analysis of FOLFOXIRI Plus Bevacizumab Versus Doublets Plus Bevacizumab as Initial Therapy of Unresectable Metastatic Colorectal Cancer, 2020, Journal of Clinical Oncology
  • Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma, 2024, Annals of Oncology
  • Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment, 2022, ESMO Open

Alfredo Falcone's published research outputs contribute to the understanding and treatment of advanced and metastatic cancers, including colorectal cancer and hepatocellular carcinoma, with a clinical focus spanning immunotherapies, combination chemotherapies, and lung disease related to cancer treatments.

Best Publications

  • ESMO consensus guidelines for the management of patients with metastatic colorectal cancer

    E. Van Cutsem;A. Cervantes;R. Adam;A. Sobrero

  • Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

    Axel Grothey;Eric Van Cutsem;Alberto Sobrero;Salvatore Siena

  • Phase III Trial of Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Compared With Infusional Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) As First-Line Treatment for Metastatic Colorectal Cancer: The Gruppo Oncologico Nord Ovest

    Alfredo Falcone;Sergio Ricci;Isa Brunetti;Elisabetta Pfanner

  • Randomized Trial of TAS-102 for Refractory Metastatic Colorectal Cancer

    Robert J Mayer;Eric Van Cutsem;Alfredo Falcone;Takayuki Yoshino

  • Pembrolizumab versus paclitaxel for previously treated, advanced gastric or gastro-oesophageal junction cancer (KEYNOTE-061): a randomised, open-label, controlled, phase 3 trial

    Kohei Shitara;Mustafa Özgüroğlu;Yung-Jue Bang;Maria Di Bartolomeo

  • FOLFOXIRI plus bevacizumab versus FOLFIRI plus bevacizumab as first-line treatment of patients with metastatic colorectal cancer: updated overall survival and molecular subgroup analyses of the open-label, phase 3 TRIBE study

    Chiara Cremolini;Fotios Loupakis;Carlotta Antoniotti;Cristiana Lupi

  • Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer

    Fotios Loupakis;Chiara Cremolini;Gianluca Masi;Sara Lonardi

  • Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

    Giulia Siravegna;Benedetta Mussolin;Michela Buscarino;Giorgio Corti

  • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

    F Loupakis;A Ruzzo;C Cremolini;B Vincenzi

  • Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial

    Miguel Martin;Frankie A Holmes;Bent Ejlertsen;Suzette Delaloge

  • Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database

    Jan Franko;Qian Shi;Jeffrey P Meyers;Timothy S Maughan

  • MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

    Elisa Giovannetti;Niccola Funel;Godefridus J. Peters;Marco Del Chiaro

  • Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial

    Cathy Eng;Tae Won Kim;Johanna Bendell;Guillem Argilés

  • PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer

    Fotios Loupakis;Luca Pollina;Irene Stasi;Annamaria Ruzzo

  • Primary Tumor Location as a Prognostic Factor in Metastatic Colorectal Cancer

    Fotios Loupakis;Dongyun Yang;Linda Yau;Shibao Feng

  • Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

    Josep Tabernero;Heinz Josef Lenz;Salvatore Siena;Alberto Sobrero

  • Quantitative evidence for early metastatic seeding in colorectal cancer.

    Zheng Hu;Jie Ding;Zhicheng Ma;Ruping Sun

  • Pharmacogenetic Profiling in Patients With Advanced Colorectal Cancer Treated With First-Line FOLFOX-4 Chemotherapy

    Annamaria Ruzzo;Francesco Graziano;Fotios Loupakis;Eliana Rulli

  • Rechallenge for Patients With RAS and BRAF Wild-Type Metastatic Colorectal Cancer With Acquired Resistance to First-line Cetuximab and Irinotecan: A Phase 2 Single-Arm Clinical Trial.

    Chiara Cremolini;Daniele Rossini;Emanuela Dell’Aquila;Sara Lonardi

  • KRAS codon 61, 146 and BRAF V600E mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

    A. Ruzzo;F. Loupakis;E. Canestrari;Chiara Cremolini

Frequent Co-Authors

Fotios Loupakis
Fotios Loupakis Istituto Oncologico Veneto
Sara Lonardi
Sara Lonardi Istituto Oncologico Veneto
Romano Danesi
Romano Danesi University of Pisa
Daniele Santini
Daniele Santini Università Campus Bio-Medico
Heinz-Josef Lenz
Heinz-Josef Lenz University of Southern California
Gabriella Fontanini
Gabriella Fontanini University of Pisa
Stefano Cascinu
Stefano Cascinu Vita-Salute San Raffaele University
Giuseppe Tonini
Giuseppe Tonini Università Campus Bio-Medico
Bruno Vincenzi
Bruno Vincenzi Università Campus Bio-Medico
Pierfranco Conte
Pierfranco Conte University of Padua

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