World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
22382
World Ranking
5012
National Ranking
2405

Overview

Julian P. Whitelegge is affiliated with the University of California, Los Angeles in the United States. Their research spans the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine. The scientist's work is notably centered around several subfields, including molecular biology, physiology, infectious diseases, oncology, and immunology.

The primary topics explored in Whitelegge's research include mitochondrial function and pathology, ubiquitin and proteasome pathways, photosynthetic processes and mechanisms, adipose tissue and metabolism, microtubule and mitosis dynamics, mass spectrometry techniques and applications, and ATP synthase and ATPases research.

Some of their recent published papers include:

  • Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury, 2020, Cell
  • CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization, 2022, Nature
  • Therapy of autoimmune inflammation in sporadic amyotrophic lateral sclerosis: Dimethyl fumarate and H-151 downregulate inflammatory cytokines in the cGAS-STING pathway, 2023, The FASEB Journal
  • Mapping Proximity Associations of Core Spindle Assembly Checkpoint Proteins, 2021, Journal of Proteome Research
  • A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs, 2023, Nature Communications

Whitelegge frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Journal of the American Society for Mass Spectrometry, Cancer Research, and International Journal of Molecular Sciences.

Collaborations are a significant aspect of Whitelegge's scientific output. Frequent co-authors include Whitaker Cohn, Lucy Gao, Erick F. Velasquez, Ankur A. Gholkar, and Jorge Z. Torres, with multiple joint publications.

Best Publications

  • A Membrane Receptor for Retinol Binding Protein Mediates Cellular Uptake of Vitamin A

    Riki Kawaguchi;Jiamei Yu;Jane Honda;Jane Hu

  • The minimum information about a proteomics experiment (MIAPE)

    Chris F. Taylor;Chris F. Taylor;Norman W. Paton;Norman W. Paton;Kathryn S. Lilley;Kathryn S. Lilley;Pierre Alain Binz;Pierre Alain Binz

  • Structure of the toxic core of α-synuclein from invisible crystals

    Jose A. Rodriguez;Magdalena I. Ivanova;Michael R. Sawaya;Duilio Cascio

  • Atomic view of a toxic amyloid small oligomer.

    Arthur Laganowsky;Cong Liu;Michael R. Sawaya;Julian P. Whitelegge

  • The proteomes of human parotid and submandibular/sublingual gland salivas collected as the ductal secretions

    Paul Denny;Fred K. Hagen;Markus Hardt;Lujian Liao

  • Characterization of serum biomarkers for detection of early stage ovarian cancer.

    Katherine R. Kozak;Feng Su;Julian P. Whitelegge;Kym Faull

  • Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.

    Daniel P. Donnelly;Catherine M. Rawlins;Caroline J. DeHart;Luca Fornelli

  • Ferredoxin:NADP+ oxidoreductase is a subunit of the chloroplast cytochrome b6f complex.

    Huamin Zhang;Julian P. Whitelegge;William A. Cramer

  • Mitochondrial Dysfunction, Through Impaired Autophagy, Leads to Endoplasmic Reticulum Stress, Deregulated Lipid Metabolism, and Pancreatitis in Animal Models

    Gyorgy Biczo;Eszter T. Vegh;Natalia Shalbueva;Olga A. Mareninova

  • Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

    Nathan HyunJoong Joh;Andrew Min;Salem Faham;Julian P. Whitelegge

  • Metal-free superoxide dismutase forms soluble oligomers under physiological conditions: A possible general mechanism for familial ALS

    Lucia Banci;Ivano Bertini;Armando Durazo;Stefania Girotto

  • The mitochondrial inner membrane protein Mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11

    Jing Xie;Michael F. Marusich;Puneet Souda;Julian Whitelegge

  • The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors

    Sarah Yohannan;Salem Faham;Duan Yang;Julian P. Whitelegge

  • Side-chain contributions to membrane protein structure and stability

    Salem Faham;Duan Yang;Emiko Bare;Sarah Yohannan

  • A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells.

    Sonal Srikanth;Hea-Jin Jung;Kyun-Do Kim;Puneet Souda

  • Initiation and elongation in fibrillation of ALS-linked superoxide dismutase

    Madhuri Chattopadhyay;Armando Durazo;Se Hui Sohn;Cynthia D. Strong

  • Identities of Sequestered Proteins in Aggregates from Cells with Induced Polyglutamine Expression

    Steven T. Suhr;Marie-Claude Senut;Julian P. Whitelegge;Kym F. Faull

  • A Peroxidase-Dependent Apoplastic Oxidative Burst in Cultured Arabidopsis Cells Functions in MAMP-Elicited Defense

    Jose Antonio O'Brien;Arsalan Daudi;Paul Finch;Vernon S Butt

  • Electrospray‐ionization mass spectrometry of intact intrinsic membrane proteins

    Julian P. Whitelegge;Cameron B. Gundersen;Kym F. Faull

  • Full subunit coverage liquid chromatography electrospray ionization mass spectrometry (LCMS+) of an oligomeric membrane protein: cytochrome b(6)f complex from spinach and the cyanobacterium Mastigocladus laminosus.

    Julian P. Whitelegge;Huamin Zhang;Rodrigo Aguilera;Ross M. Taylor

Frequent Co-Authors

Kym F. Faull
Kym F. Faull University of California, Los Angeles
William A. Cramer
William A. Cramer Purdue University West Lafayette
Joan Selverstone Valentine
Joan Selverstone Valentine University of California, Los Angeles
Joseph A. Loo
Joseph A. Loo University of California, Los Angeles
Alan J. Waring
Alan J. Waring University of California, Los Angeles
Steven Clarke
Steven Clarke University of California, Los Angeles
David Eisenberg
David Eisenberg Harvard University
Peipei Ping
Peipei Ping University of California, Los Angeles
David R. Borchelt
David R. Borchelt University of Florida
Robert Damoiseaux
Robert Damoiseaux University of California, Los Angeles

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