Rudi Lurz spends much of his time researching Biochemistry, Molecular biology, Cell biology, Huntingtin and Peptide sequence. His Molecular biology research integrates issues from Plasmid, DNA, DNA replication, Biophysics and Mutant. His Plasmid study combines topics from a wide range of disciplines, such as Pilus and Escherichia coli.
His work carried out in the field of Cell biology brings together such families of science as Endothelial stem cell, Embryonic stem cell, Induced pluripotent stem cell and Reprogramming. The various areas that he examines in his Huntingtin study include Hsp90 and Geldanamycin. Rudi Lurz has researched Peptide sequence in several fields, including Protein structure and Relaxosome, Relaxase.
His primary areas of investigation include Molecular biology, DNA, Biochemistry, Plasmid and Genetics. His Molecular biology study integrates concerns from other disciplines, such as Nucleic acid sequence, Gene, Mutant and DNA replication. His DNA study combines topics in areas such as Biophysics, Bacillus subtilis, Binding site and Cell biology.
His studies deal with areas such as Huntingtin and Induced pluripotent stem cell as well as Cell biology. Rudi Lurz combines subjects such as Nuclear protein, Protein aggregation and Fibrillogenesis with his study of Huntingtin. His work in the fields of Biochemistry, such as Peptide sequence, Protein structure and Nucleotide, overlaps with other areas such as Membrane protein.
Rudi Lurz mainly focuses on DNA, Molecular biology, Cell biology, Biochemistry and Gene. His DNA research incorporates themes from Cytoplasm and Transcription factor. His studies deal with areas such as Biophysics, Mutation and Cytosol as well as Molecular biology.
Rudi Lurz has researched Cell biology in several fields, including Mutant, Capsid, Induced pluripotent stem cell, Oxidative Stress Pathway and Neuroscience. His Gene research entails a greater understanding of Genetics. His Long-term potentiation research incorporates elements of Fibril, Fibrillogenesis, Beta sheet and Small molecule.
Rudi Lurz mostly deals with Molecular biology, Cell biology, Peptide sequence, Peptide and Amyloid precursor protein. His studies in Molecular biology integrate themes in fields like DNA replication factor CDT1, Origin recognition complex, Eukaryotic DNA replication, Biophysics and Mutant. His Mutant study integrates concerns from other disciplines, such as Receptor, Teichoic acid, Cell envelope and DNA.
The study incorporates disciplines such as Reprogramming and Embryonic stem cell, Induced pluripotent stem cell in addition to Cell biology. His work deals with themes such as Protein structure, Missense mutation, Neprilysin and Small molecule, which intersect with Peptide sequence. His Peptide research is multidisciplinary, relying on both Promoter and Chromatin immunoprecipitation.
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Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo
Eberhard Scherzinger;Rudi Lurz;Mark Turmaine;Laura Mangiarini.
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.
Dagmar E Ehrnhoefer;Jan Bieschke;Annett Boeddrich;Martin Herbst.
Nature Structural & Molecular Biology (2008)
Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology
Eberhard Scherzinger;Annie Sittler;Katja Schweiger;Volker Heiser.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation
Stephanie Waelter;Annett Boeddrich;Rudi Lurz;Eberhard Scherzinger.
Molecular Biology of the Cell (2001)
The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells.
Alessandro Prigione;Beatrix Fauler;Rudi Lurz;Hans Lehrach.
Stem Cells (2010)
A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
Cecile Evrin;Pippa Clarke;Juergen Zech;Rudi Lurz.
Proceedings of the National Academy of Sciences of the United States of America (2009)
Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington’s disease
Annie Sittler;Rudi Lurz;Gerhild Lueder;Josef Priller.
Human Molecular Genetics (2001)
Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils
Jan Bieschke;Martin Herbst;Martin Herbst;Thomas Wiglenda;Ralf P Friedrich.
Nature Chemical Biology (2012)
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.
Volker Heiser;Eberhard Scherzinger;Annett Boeddrich;Eckhard Nordhoff.
Proceedings of the National Academy of Sciences of the United States of America (2000)
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay.
Volker Heiser;Sabine Engemann;Wolfgang Bröcker;Ilona Dunkel.
Proceedings of the National Academy of Sciences of the United States of America (2002)
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