What is he best known for?
The fields of study he is best known for:
Erich E. Wanker focuses on Huntingtin, Huntingtin Protein, Cell biology, Biochemistry and Protein aggregation.
His Huntingtin study is concerned with the larger field of Huntington's disease.
His Huntingtin Protein research is multidisciplinary, relying on both Molecular biology, Polyglutamine tract and Signal transducing adaptor protein.
His research integrates issues of Huntingtin-interacting protein 1, Binding protein, Transgene and Heat shock protein in his study of Cell biology.
His research in Fibrillogenesis tackles topics such as Amyloid which are related to areas like Amino acid.
The Genetics study combines topics in areas such as Scoring system and Computational biology.
His most cited work include:
- A human protein-protein interaction network : a resource for annotating the proteome (1963 citations)
- FORMATION OF NEURONAL INTRANUCLEAR INCLUSIONS UNDERLIES THE NEUROLOGICAL DYSFUNCTION IN MICE TRANSGENIC FOR THE HD MUTATION (1947 citations)
- Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo (1129 citations)
What are the main themes of his work throughout his whole career to date?
Erich E. Wanker spends much of his time researching Cell biology, Huntingtin, Biochemistry, Genetics and Huntingtin Protein.
He has included themes like Ubiquitin, Pathogenesis, Apoptosis, Programmed cell death and Inclusion bodies in his Cell biology study.
His Huntingtin research is multidisciplinary, incorporating perspectives in Molecular biology, Nuclear protein and Neurodegeneration.
His Biochemistry research incorporates elements of Toxicity and Amyloid.
His studies deal with areas such as Plasma protein binding and Computational biology as well as Genetics.
His biological study spans a wide range of topics, including Mutation, Polyglutamine tract and Signal transducing adaptor protein.
He most often published in these fields:
- Cell biology (33.33%)
- Huntingtin (30.86%)
- Biochemistry (20.99%)
What were the highlights of his more recent work (between 2017-2021)?
- Cell biology (33.33%)
- Huntington's disease (14.40%)
- Huntingtin (30.86%)
In recent papers he was focusing on the following fields of study:
His primary scientific interests are in Cell biology, Huntington's disease, Huntingtin, Biophysics and Fibril.
His Cell biology research integrates issues from Pathogenesis, Mutant, Gene, Cofactor and Genetically modified mouse.
His specific area of interest is Huntington's disease, where he studies Huntingtin Protein.
He interconnects RNA-binding protein and RNA splicing, Spliceosome in the investigation of issues within Huntingtin.
His Biophysics research is multidisciplinary, incorporating elements of Lewy body and Amyloid fibril, Amyloid.
In his research, Peptide, Plasma protein binding, Bioluminescence and Neuronal ceroid lipofuscinosis is intimately related to Small molecule, which falls under the overarching field of Fibril.
Between 2017 and 2021, his most popular works were:
- Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex (55 citations)
- Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. (47 citations)
- mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease. (25 citations)
In his most recent research, the most cited papers focused on:
His main research concerns Cell biology, Huntingtin, Huntington's disease, Fibril and Neuroscience.
His study in Cell biology is interdisciplinary in nature, drawing from both HEK 293 cells, Chaperone complex, Mutant and Trinucleotide repeat expansion.
His Huntingtin study frequently draws parallels with other fields, such as Small molecule.
The various areas that Erich E. Wanker examines in his Huntington's disease study include Phenotype and Inclusion bodies.
His Neuroscience study integrates concerns from other disciplines, such as Huntingtin Protein, Protein aggregation, Polyglutamine tract and Proteomics.
His Huntingtin Protein research is classified as research in Disease.
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