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Molecular Biology

D-Index
82
Citations
34910
World Ranking
917
National Ranking
75

Overview

Erich E. Wanker is affiliated with the Max Delbrück Center for Molecular Medicine in Germany. Their research encompasses multiple aspects of biochemistry, genetics, molecular biology, and neuroscience, with a focus also on medicine. The main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience
  • Medicine

The scientist's work extends into various subfields such as:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology
  • Physiology
  • Neurology

Main topics covered by their research are:

  • Genetic Neurodegenerative Diseases
  • Mitochondrial Function and Pathology
  • Alzheimer's disease research and treatments
  • Endoplasmic Reticulum Stress and Disease
  • Neurological disorders and treatments
  • RNA Research and Splicing
  • Bioinformatics and Genomic Networks

Erich E. Wanker has contributed to multiple peer-reviewed papers. Some notable publications include:

  • "Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome," 2021, Nature Communications
  • "Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains," 2020, Cell Reports
  • "Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington's Disease Model," 2020, Brain Communications
  • "Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils," 2020, Chemical Communications
  • "Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease," 2022, Cell Systems

Erich E. Wanker has worked frequently with the following coauthors:

  • Eduardo Silva Ramos
  • Christopher Secker
  • Josef Priller
  • Alessandro Prigione
  • Martina Zenkner

Key publication venues where this scientist has been regularly published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Molecular Biology
  • Stem Cell Research
  • Nature Communications
  • Brain Communications

Best Publications

  • FORMATION OF NEURONAL INTRANUCLEAR INCLUSIONS UNDERLIES THE NEUROLOGICAL DYSFUNCTION IN MICE TRANSGENIC FOR THE HD MUTATION

    Stephen W Davies;Mark Turmaine;Barbara A Cozens;Marian DiFiglia

  • A human protein-protein interaction network : a resource for annotating the proteome

    Ulrich Stelzl;Uwe Worm;Maciej Lalowski;Christian Haenig

  • Huntingtin-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo

    Eberhard Scherzinger;Rudi Lurz;Mark Turmaine;Laura Mangiarini

  • EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers.

    Dagmar E Ehrnhoefer;Jan Bieschke;Annett Boeddrich;Martin Herbst

  • The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

    Joan S. Steffan;Aleksey Kazantsev;Olivera Spasic-Boskovic;Marilee Greenwald

  • EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

    Jan Bieschke;Jenny Russ;Ralf P. Friedrich;Dagmar E. Ehrnhoefer

  • An empirical framework for binary interactome mapping

    Kavitha Venkatesan;Kavitha Venkatesan;Jean François Rual;Alexei Vazquez;Alexei Vazquez;Ulrich Stelzl

  • Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

    Eberhard Scherzinger;Annie Sittler;Katja Schweiger;Volker Heiser

  • Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation

    Stephanie Waelter;Annett Boeddrich;Rudi Lurz;Eberhard Scherzinger

  • Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

    Paul J. Muchowski;Gregor Schaffar;Annie Sittler;Erich E. Wanker

  • The hunt for huntingtin function: interaction partners tell many different stories.

    Phoebe Harjes;Erich E Wanker

  • A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington’s Disease

    Heike Goehler;Maciej Lalowski;Ulrich Stelzl;Stephanie Waelter

  • Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington’s disease

    Annie Sittler;Rudi Lurz;Gerhild Lueder;Josef Priller

  • Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

    Jan Bieschke;Martin Herbst;Martin Herbst;Thomas Wiglenda;Ralf P Friedrich

  • HIP-I: A huntingtin interacting protein isolated by the yeast two-hybrid system

    Erich E. Wanker;Carlos Rovira;Eberhard Scherzinger;Renate Hasenbank

  • Green tea (−)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

    Dagmar E. Ehrnhoefer;Martin Duennwald;Phoebe Markovic;Jennifer L. Wacker

  • Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.

    Volker Heiser;Eberhard Scherzinger;Annett Boeddrich;Eckhard Nordhoff

  • HIPPIE: Integrating protein interaction networks with experiment based quality scores.

    Martin H. Schaefer;Jean-Fred Fontaine;Arunachalam Vinayagam;Arunachalam Vinayagam;Pablo Porras;Pablo Porras

  • A directed protein interaction network for investigating intracellular signal transduction.

    Arunachalam Vinayagam;Ulrich Stelzl;Raphaele Foulle;Stephanie Plassmann

  • Plant nitric oxide synthase: a never-ending story?

    Tomasz Zemojtel;Andreas Fröhlich;M. Cristina Palmieri;Mateusz Kolanczyk

Frequent Co-Authors

Hans Lehrach
Hans Lehrach Max Planck Society
Gillian P. Bates
Gillian P. Bates University College London
Rudi Lurz
Rudi Lurz Max Planck Society
Josef Priller
Josef Priller Charité - University Medicine Berlin
Miguel A. Andrade-Navarro
Miguel A. Andrade-Navarro Johannes Gutenberg University of Mainz
Udo Heinemann
Udo Heinemann Max Delbrück Center for Molecular Medicine
Ichiro Kanazawa
Ichiro Kanazawa University of Tokyo
Markus Ralser
Markus Ralser Charité - University Medicine Berlin
Jan Tavernier
Jan Tavernier Ghent University
Bernd Reif
Bernd Reif Technical University of Munich

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