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Nobuyuki Nukina

Nobuyuki Nukina

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
53110
World Ranking
3604
National Ranking
225

Overview

Nobuyuki Nukina is affiliated with Doshisha University in Japan and conducts research primarily in the fields of biochemistry, genetics, molecular biology, and medicine. Their work focuses on molecular biology, neurology, physiology, genetics, and cellular and molecular neuroscience, with a significant emphasis on neurodegenerative diseases and RNA-related regulation and pathology.

The scientist's main research topics include:

  • Parkinson's Disease Mechanisms and Treatments
  • RNA regulation and disease
  • Alzheimer's disease research and treatments
  • Prion Diseases and Protein Misfolding
  • RNA Research and Splicing
  • Neurological disorders and treatments
  • Amyotrophic Lateral Sclerosis Research

Nukina has published numerous papers in notable scientific venues including Scientific Reports, Neuroscience Research, Nature Medicine, Journal of Biological Chemistry, and Contact. The frequent publication venues reflect a strong connection to molecular and neurological topics.

Recent papers authored or co-authored by Nukina include:

  • Propagative α-synuclein seeds as serum biomarkers for synucleinopathies, 2023, Nature Medicine
  • CELF2 regulates the species-specific alternative splicing of TREM2, 2020, Scientific Reports
  • Proteomics-Based Approach Identifies Altered ER Domain Properties by ALS-Linked VAPB Mutation, 2020, Scientific Reports
  • Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?, 2021, Contact
  • FACS-array-based cell purification yields a specific transcriptome of striatal medium spiny neurons in a murine Huntington disease model, 2020, Journal of Biological Chemistry

The collaboration network of Nobuyuki Nukina includes several frequent co-authors, indicating substantial cooperative research efforts. These co-authors include Tomoyuki Yamanaka, Nobutaka Hattori, Tomomi Shimogori, Haruko Miyazaki, and Yukio Imamura.

Their research contributions also span disease mechanisms relating to various neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Many of the studies involve investigations into RNA regulation, alternative splicing, protein misfolding, and biomarker identification for synucleinopathies.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

    Takeshi Iwatsubo;Asano Odaka;Nobuhiro Suzuki;Hidehiro Mizusawa

  • Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease.

    Motomasa Tanaka;Yoko Machida;Sanyong Niu;Tetsurou Ikeda

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

    Gen Matsumoto;Koji Wada;Misako Okuno;Masaru Kurosawa

  • Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer??s disease

    Y Ihara;N Nukina;R Miura;M Ogawara

  • Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

    Nihar Ranjan Jana;Evgueni A. Zemskov;Guang-hui Wang;Nobuyuki Nukina

  • Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

    Nihar Ranjan Jana;Motomasa Tanaka;Guang-hui Wang;Nobuyuki Nukina

  • Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes

    Kulandaivelu S. Vetrivel;Haipeng Cheng;William Lin;Takashi Sakurai

  • Eukaryotic Proteasomes Cannot Digest Polyglutamine Sequences and Release Them during Degradation of Polyglutamine-Containing Proteins

    Prasanna Venkatraman;Ronald Wetzel;Motomasa Tanaka;Nobuyuki Nukina

  • Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.

    Makoto Urushitani;Attila Sik;Takashi Sakurai;Nobuyuki Nukina

  • One of the antigenic determinants of paired helical filaments is related to tau protein.

    Nobuyuki Nukina;Yasuo Ihara

  • Semi-rational engineering of a coral fluorescent protein into an efficient highlighter

    Hidekazu Tsutsui;Satoshi Karasawa;Hideaki Shimizu;Nobuyuki Nukina

  • β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase

    Hon Kit Wong;Takashi Sakurai;Fumitaka Oyama;Kumi Kaneko

  • Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation.

    Atsushi Iwata;John C. Christianson;Mirella Bucci;Lisa M. Ellerby

  • Co-chaperone CHIP Associates with Expanded Polyglutamine Protein and Promotes Their Degradation by Proteasomes

    Nihar Ranjan Jana;Priyanka Dikshit;Anand Goswami;Svetlana Kotliarova

  • TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

    Gen Matsumoto;Tomomi Shimogori;Nobutaka Hattori;Nobuyuki Nukina

  • A Functional Null Mutation of SCN1B in a Patient with Dravet Syndrome

    Gustavo A. Patino;Lieve R.F. Claes;Luis F. Lopez-Santiago;Emily A. Slat

Frequent Co-Authors

Ichiro Kanazawa
Ichiro Kanazawa University of Tokyo
Nobutaka Hattori
Nobutaka Hattori Juntendo University
Yasuo Ihara
Yasuo Ihara Doshisha University
Koji Yamanaka
Koji Yamanaka Nagoya University
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
Sergio Lavandero
Sergio Lavandero University of Chile
Tsutomu Hashikawa
Tsutomu Hashikawa RIKEN Center for Brain Science
Evelina Gatti
Evelina Gatti Aix-Marseille University
Ryosuke Takahashi
Ryosuke Takahashi Kyoto University
Beth Levine
Beth Levine The University of Texas Southwestern Medical Center

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