D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 69 Citations 14,206 286 World Ranking 3872 National Ranking 1346
Biology and Biochemistry D-index 69 Citations 13,687 265 World Ranking 4778 National Ranking 2358

Research.com Recognitions

Awards & Achievements

2015 - Fellow, National Academy of Inventors

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Organic chemistry
  • DNA

Chung K. Chu focuses on Stereochemistry, Virus, Nucleoside, Virology and Biochemistry. His study in Stereochemistry is interdisciplinary in nature, drawing from both Uridine, Cytosine, Cytotoxicity, Structure–activity relationship and Chemical synthesis. The Cytosine study combines topics in areas such as Uracil and Pyrimidine.

The concepts of his Virus study are interwoven with issues in Biological activity and Enantiomer. His study in the fields of Nucleoside analogue under the domain of Nucleoside overlaps with other disciplines such as Monkeypox virus, Monkeypox and Cowpox virus. His Virology research integrates issues from Molecular biology and Reverse transcriptase.

His most cited work include:

  • Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. (335 citations)
  • Chemistry and antiviral activities of acyclonucleosides (259 citations)
  • Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication. (244 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Stereochemistry, Nucleoside, Virology, Virus and Pyrimidine. The various areas that he examines in his Stereochemistry study include Cytosine, Nucleic acid, Chemical synthesis and Purine. His research in Nucleoside intersects with topics in Prodrug, Pharmacology and Biological activity.

His primary area of study in Virology is in the field of Hepatitis B virus. Chung K. Chu has included themes like Molecular biology, In vitro and Uracil in his Virus study. Chung K. Chu works mostly in the field of Biochemistry, limiting it down to concerns involving Reverse transcriptase and, occasionally, Nucleotidyltransferase and Active site.

He most often published in these fields:

  • Stereochemistry (49.45%)
  • Nucleoside (25.68%)
  • Virology (19.95%)

What were the highlights of his more recent work (between 2003-2020)?

  • Stereochemistry (49.45%)
  • Nucleoside (25.68%)
  • Virology (19.95%)

In recent papers he was focusing on the following fields of study:

Chung K. Chu mainly investigates Stereochemistry, Nucleoside, Virology, Virus and Biochemistry. His Stereochemistry research includes themes of Enzyme, Purine, Active site and Chemical synthesis. His Nucleoside study integrates concerns from other disciplines, such as Guanosine, Biological activity, In vitro and Pharmacology.

His Virology study deals with Resistance mutation intersecting with Thymine. His Virus study incorporates themes from Cell culture and Molecular biology. His work in the fields of Biochemistry, such as Adenosine, Ribose and Binding site, overlaps with other areas such as Toxoplasma gondii.

Between 2003 and 2020, his most popular works were:

  • Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2 (195 citations)
  • Fluorinated Nucleosides: Synthesis and Biological Implication (133 citations)
  • Synthesis of Cyclopentenyl Carbocyclic Nucleosides as Potential Antiviral Agents Against Orthopoxviruses and SARS (107 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Organic chemistry
  • DNA

Chung K. Chu spends much of his time researching Stereochemistry, Nucleoside, Chemical synthesis, Biological activity and Virus. His studies in Stereochemistry integrate themes in fields like Enzyme, Active site and In vitro, Structure–activity relationship. His study in Nucleoside is interdisciplinary in nature, drawing from both Mechanism of action and Nucleotidyltransferase.

The Biological activity study combines topics in areas such as Combinatorial chemistry, Resistance mutation, Molecule and Thymidine. The research on Virology and Immunology is part of his Virus project. His work deals with themes such as Thymine and Drug resistance, which intersect with Virology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.

R F Schinazi;R M Lloyd;M H Nguyen;D L Cannon.
Antimicrobial Agents and Chemotherapy (1993)

461 Citations

Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

R F Schinazi;C K Chu;A Peck;A McMillan.
Antimicrobial Agents and Chemotherapy (1992)

400 Citations

Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

C.N. Chang;S.L. Doong;J.H. Zhou;J.W. Beach.
Journal of Biological Chemistry (1992)

355 Citations

Chemistry and antiviral activities of acyclonucleosides

Chung K. Chu;Stephen J. Cutler.
Journal of Heterocyclic Chemistry (1986)

352 Citations

Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.

C K Chu;T Ma;K Shanmuganathan;C Wang.
Antimicrobial Agents and Chemotherapy (1995)

313 Citations

Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

J. Warren Beach;Lak S. Jeong;Antonio J. Alves;Douglas Pohl.
Journal of Organic Chemistry (1992)

286 Citations

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

Julia Friedman;Won Kyung Cho;Chung K. Chu;Kara S. Keedy.
Journal of Virology (2011)

274 Citations

Nucleosides and nucleotides as antitumor and antiviral agents

Chung K. Chu;David C. Baker;Antiviral Agents.
(1993)

241 Citations

Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

Lieven J. Stuyver;Tony Whitaker;Tamara R. McBrayer;Brenda I. Hernandez-Santiago.
Antimicrobial Agents and Chemotherapy (2003)

230 Citations

Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.

L. S. Jeong;R. F. Schinazi;J. W. Beach;H. O. Kim.
Journal of Medicinal Chemistry (1993)

229 Citations

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