World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
73
Citations
16906
World Ranking
5047
National Ranking
1571

Biology and Biochemistry

D-Index
73
Citations
17003
World Ranking
6015
National Ranking
2837

Research.com Recognitions

  • 2015 - Fellow, National Academy of Inventors

Overview

Chung K. Chu is affiliated with the University of Georgia in the United States and focuses primarily on medical research with a strong emphasis on epidemiology and infectious diseases. The scientist's work intersects pharmaceutical science, molecular biology, and immunology, addressing topics relevant to virus research and drug development.

Their research covers several main topics including:

  • Cytomegalovirus and herpesvirus research
  • HIV/AIDS drug development and treatment
  • Herpesvirus infections and treatments
  • Fluorine in organic chemistry
  • Biochemical and molecular research
  • Hepatitis C virus research
  • Toxin mechanisms and immunotoxins

Frequent collaborators in their work include Uma S. Singh, Yugandhar Kothapalli, Ransom A. Jones, Dongmei Liu, and Jennifer F. Moffat. These coauthors have contributed to multiple joint publications, reflecting a sustained collaborative research effort.

Chung K. Chu has published research in various scientific venues. Notable publication venues are:

  • Molecules
  • Nucleosides Nucleotides & Nucleic Acids
  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ChemistrySelect

Some recent papers authored or co-authored by Chung K. Chu include:

  • Synthesis of 2'-deoxy-2'-fluoro-2'-C-methyl spiro cyclopentyl carbocyclic uridine analog as potential inhibitors of HCV NS5B polymerase, 2020, Nucleosides Nucleotides & Nucleic Acids
  • Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral Properties, 2024, Molecules
  • Prodrug Strategies for the Development of β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU) against Varicella Zoster Virus (VZV), 2023, Journal of Medicinal Chemistry
  • β-L-1-[5-(E-2-Bromovinyl)-2-(Hydroxymethyl)-1,3-Dioxolan-4-yl)] Uracil (L-BHDU) Inhibits Varicella Zoster Virus Replication by Depleting the Cellular dTTP Pool, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • A Stereoselective Synthesis of 4'- α -Fluoro-methyl Carbocyclic Nucleoside Analogs, 2023, ChemistrySelect

Chung K. Chu was recognized as a Fellow of the National Academy of Inventors in 2015, an award reflecting distinction in innovation.

Best Publications

  • Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides.

    R F Schinazi;R M Lloyd;M H Nguyen;D L Cannon

  • Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

    R F Schinazi;C K Chu;A Peck;A McMillan

  • Chemistry and antiviral activities of acyclonucleosides

    Chung K. Chu;Stephen J. Cutler

  • Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

    C.N. Chang;S.L. Doong;J.H. Zhou;J.W. Beach

  • Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

    Julia Friedman;Won Kyung Cho;Chung K. Chu;Kara S. Keedy

  • Use of 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil as a novel antiviral agent for hepatitis B virus and Epstein-Barr virus.

    C K Chu;T Ma;K Shanmuganathan;C Wang

  • Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

    J. Warren Beach;Lak S. Jeong;Antonio J. Alves;Douglas Pohl

  • Ribonucleoside Analogue That Blocks Replication of Bovine Viral Diarrhea and Hepatitis C Viruses in Culture

    Lieven J. Stuyver;Tony Whitaker;Tamara R. McBrayer;Brenda I. Hernandez-Santiago

  • Nucleosides and nucleotides as antitumor and antiviral agents

    Chung K. Chu;David C. Baker;Antiviral Agents

  • Fluorinated Nucleosides: Synthesis and Biological Implication

    Peng Liu;Ashoke Sharon;Chung K. Chu

  • Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.

    L. S. Jeong;R. F. Schinazi;J. W. Beach;H. O. Kim

  • Anticancer Activity of β-l-Dioxolane-cytidine, a Novel Nucleoside Analogue with the Unnatural l Configuration

    Kristie L. Grove;Xin Guo;Shwu-Huey Liu;Zhiling Gao

  • Anthraquinones as a new class of antiviral agents against human immunodeficiency virus.

    Raymond F. Schinazi;Chung K. Chu;J. Ramesh Babu;Barbara J. Oswald

  • General syntheses of 2',3'-dideoxynucleosides and 2',3'-didehydro-2',3'-dideoxynucleosides

    C. K. Chu;V. S. Bhadti;B. Doboszewski;Z. P. Gu

  • Development and optimization of anti-HIV nucleoside analogs and prodrugs: A review of their cellular pharmacology, structure-activity relationships and pharmacokinetics.

    Xiaolei Tan;Chung K. Chu;F.Douglas Boudinot

  • Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells.

    Chung K. Chu;Raymond F. Schinazi;Moon K. Ahn;Giliyar V. Ullas

  • Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.

    S. Balakrishna Pai;Shwu-Huey Liu;Yong-Lian Zhu;C. K. Chu

  • Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

    Kim Ho;Ahn Sk;Alves Aj;Beach Jw

  • Structure−Activity Relationships of 1-(2-Deoxy-2-fluoro-β-l-arabino- furanosyl)pyrimidine Nucleosides as Anti-Hepatitis B Virus Agents

    T Ma;S B Pai;Y L Zhu;J S Lin

  • Synthesis of Cyclopentenyl Carbocyclic Nucleosides as Potential Antiviral Agents Against Orthopoxviruses and SARS

    Jong Hyun Cho;Dale L Bernard;Robert W Sidwell;Earl R Kern

  • Antiviral Activities and Cellular Toxicities of Modified 2′,3′-Dideoxy-2′,3′-Didehydrocytidine Analogues

    Lieven J. Stuyver;Stefania Lostia;Marjorie Adams;Judy S. Mathew

Frequent Co-Authors

Raymond F. Schinazi
Raymond F. Schinazi Emory University
Yung-Chi Cheng
Yung-Chi Cheng Yale University
Raymond F. Schinazi
Raymond F. Schinazi Emory University
Jack J. Fox
Jack J. Fox Memorial Sloan Kettering Cancer Center
Adrian S. Ray
Adrian S. Ray Yale University
Michael G. Bartlett
Michael G. Bartlett University of Georgia
Lak Shin Jeong
Lak Shin Jeong Seoul National University
Karen S. Anderson
Karen S. Anderson Yale University
Brent E. Korba
Brent E. Korba Georgetown University
Paul J. Cote
Paul J. Cote Georgetown University Medical Center

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